RELATIONSHIP BETWEEN POLYCYSTIC OVARY SYNDROME (PCOS) AND GUTMICROBIOTA – NEW FINDINGS
Abstract
Polycystic Ovary Syndrome (PCOS) is a prevalent endocrinopathy associated with metabolic, hormonal, and inflammatory alterations, whose pathophysiology is not yet fully elucidated. Recent evidence suggests that the gut microbiota plays a relevant role in this context. This study aimed to critically synthesize the evidence regarding the relationship between gut microbiota and PCOS, considering metabolic, inflammatory, and hormonal mechanisms. This is an integrative literature review, with a qualitative approach, conducted in the PubMed, SciELO, and Virtual Health Library databases. Studies published in the last ten years, in English, Portuguese, and Spanish, addressing the interaction between gut microbiota and PCOS were included. After applying eligibility criteria, 23 studies were analyzed. The results showed that women with PCOS present intestinal dysbiosis, characterized by reduced microbial diversity and increased pro-inflammatory bacteria. This imbalance is associated with increased intestinal permeability, lipopolysaccharide-mediated endotoxemia, chronic low-grade inflammation, and insulin resistance, contributing to hyperandrogenism. In addition, alterations in metabolites such as short-chain fatty acids, bile acids, and cytokines such as IL-22 demonstrated a direct impact on metabolic homeostasis and ovarian function.
Author Biographies
Physician. Universidade Nove de Julho, Guarulhos-SP, Brazil.
Physician. Centro Universitário Barão de Mauá, Ribeirão Preto-SP, Brazil.
Medical student. Universidade Nove de Julho, São Paulo-SP, Brazil.
Medical student. Universidade Nove de Julho, São Paulo-SP, Brazil.
Medical student. Universidade Nove de Julho, São Paulo-SP, Brazil.
Medical student. Universidade Nove de Julho, São Paulo-SP, Brazil.
Medical student. Universidade Nove de Julho, São Paulo-SP, Brazil.
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