FIBROMIA: AN INTEGRATIVE REVIEW OF LITERATURE
Abstract
Fibromyalgia is a syndrome characterized by chronic and diffuse musculoskeletal pain, often associated with fatigue, sleep disturbances, and impaired quality of life. Conventional treatments, based on antidepressants, anticonvulsants, and analgesics, show variable effectiveness and may be associated with relevant adverse effects. Therefore, scientific interest in medical cannabis as a complementary therapeutic approach has increased. The main active compounds of the plant, tetrahydrocannabinol (THC) and cannabidiol (CBD), interact with the endocannabinoid system, modulating neurophysiological processes related to pain, sleep, and mood. This integrative review aims to critically analyze the available evidence on the effectiveness of medical cannabis and cannabinoids in the management of fibromyalgia, with emphasis on pain, sleep quality, and quality of life. This study is an integrative literature review conducted in previously defined databases, based on established inclusion and exclusion criteria. PubMed/MEDLINE, BVS/LILACS, SciELO, Cochrane Library, Scopus, and Web of Science were searched for publications from 2008 to 2025. The analyzed studies suggest that cannabinoids may contribute to pain reduction and sleep improvement in some patients. However, the literature still presents methodological limitations, heterogeneity of formulations, and a lack of long-term studies, requiring caution in the clinical incorporation of these products.
Author Biographies
Graduate from the 10th period of the Pharmacy course, with training focused on Pharmaceutical Sciences and interest in areas related to health, research and pharmaceutical assistance. He has academic experience in the development of scientific studies, with emphasis on the application of theoretical knowledge to clinical and laboratory practice.
Graduate in Chemistry and Bachelor's Degree from the Federal Institute of Maranhão (2010), Bachelor's Degree in Pharmacy with Biochemistry degree from the Federal University of Maranhão (2012), Master's Degree in Chemistry from the Federal University of Maranhão (2014) and Ph.D. in Chemistry from the Federal University of Maranhão (2025). Public servant of the Federal University of Maranhão linked to the Coordination of the Industrial Chemistry Course (COQUIN), professor of higher education at the Florence University Center and partner/founder of the Hempense startup
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