DESAFIOS NO MANEJO DA ESCLEROSE MÚLTIPLA PRECOCE EM UMA CRIANÇA COM 5 ANOS DE IDADE: RELATO DE CASO

Autores

DOI:

https://doi.org/10.47820/recima21.v3i12.2247

Palavras-chave:

Multiple Sclerosis, Autoimmune disease

Resumo

Este estudo relata o caso de uma criança com Esclerose Múltipla precoce. É uma doença inflamatória do Sistema Nervoso Central, mais comum em adultos, considerada muito rara na primeira década de vida. O paciente tinha 5 anos quando sofreu ataques agudos de ataxia e paparese. A ressonância magnética do encéfalo mostrou lesões compatíveis com a doença, embora o líquido cefalorraquidiano não tenha detectado alterações típicas. Houve recuperação dos surtos e dificuldades para utilizar o tratamento imunomodulador. Isso reflete o quanto o diagnóstico e manejo em crianças e adolescentes é mais difícil, pois apresentam sintomas inespecíficos que abrem um leque de diferentes diagnósticos diferenciais. Portanto, o relato destaca as diferenças entre a esclerose múltipla em adultos e crianças e as dificuldades nessa população específica.

Downloads

Não há dados estatísticos.

Biografias Autor

Adriele Feitosa Ribeiro

MD, Department of Integrated Health, State University of Pará (UEPA), Santarém-PA, Brazil

 

Susan Karolayne Silva Pimentel

MD, Department of Integrated Health, State University of Pará (UEPA), Santarém-PA, Brazil

 

Ana Flávia Ribeiro Nascimento

MD, Department of Integrated Health, State University of Pará (UEPA), Santarém-PA, Brazil

 

Aríssia Micaelle Coelho Sousa

MD, Department of Integrated Health, State University of Pará (UEPA), Santarém-PA, Brazil

 

Juliana Ferreira da Silva

MD, Department of Integrated Health, State University of Pará (UEPA), Santarém-PA, Brazil

 

Leoneide Érica Maduro Bouillet

PhD, Biologist, Morphofunctional Department, State University of Pará (UEPA), Santarém-PA, Brazil

 

Marcos Manoel Honorato

PhD, MD, Neurology specialist. Department of Integrated Health, State University of Pará (UEPA), Santarém-PA, Brazil. Professor of The Medical Course

 

Referências

Wendel‐Haga M, Celius E. Is the hygiene hypothesis relevant for the risk of multiple sclerosis? Acta Neurologica Scandinavica 2017;136:26-30.

Brenton JN, Kammeyer R, Gluck L, Schreiner T, Makhani N. Multiple Sclerosis in Children: Current and Emerging Concepts. Seminars in neurology; 2020: Thieme Medical Publishers: 192-200.

da Gama ABCN, Lacativa MCS, da Costa Pereira FFC, Alvarenga RMP. Prevalence of multiple sclerosis in Brazil: A systematic review. Multiple sclerosis and related disorders 2015;4:572-579.

Leray E, Moreau T, Fromont A, Edan G. Epidemiology of multiple sclerosis. Revue neurologique 2016;172:3-13.

Lassmann H. Pathogenic mechanisms associated with different clinical courses of multiple sclerosis. Frontiers in Immunology 2019:3116.

Sommer RC, Hata J, de Medeiros Rimkus C, da Costa BK, Nakahara J, Sato DK. Mechanisms of myelin repair, MRI techniques and therapeutic opportunities in multiple sclerosis. Multiple Sclerosis and Related Disorders 2021:103407.

Hung P-C, Wang H-S, Chou M-L, Lin K-L, Hsieh M-Y, Wong AM. Acute disseminated encephalomyelitis in children: a single institution experience of 28 patients. Neuropediatrics 2012;43:064-071.

An Q, Fan C, Xu S. Childhood multiple sclerosis: clinical features and recent developments on treatment choices and outcomes. Eur Rev Med Pharmacol Sci 2018;22:5747-5754.

McKay KA, Hillert J, Manouchehrinia A. Long-term disability progression of pediatric-onset multiple sclerosis. Neurology 2019;92:e2764-e2773.

Alroughani R, Boyko A. Pediatric multiple sclerosis: a review. BMC neurology 2018;18:1-8.

Mirza A, Forbes JD, Zhu F, et al. The multiple sclerosis gut microbiota: A systematic review. Multiple Sclerosis and Related Disorders 2020;37:101427.

Tremlett H, Waubant E. The gut microbiota and pediatric multiple sclerosis: recent findings. Neurotherapeutics 2018;15:102-108.

Eskandarieh S, Sahraiain MA, Molazadeh N, Moghadasi AN. Pediatric multiple sclerosis and its familial recurrence: a population based study (1999–2017). Multiple sclerosis and related disorders 2019;36:101377.

Luca M, Ortega-Castro N, Patti F. Paediatric Multiple Sclerosis: A Scoping Review of Patients’ and Parents’ Perspectives. Children 2021;9:11.

Duquette P, Murray TJ, Pleines J, et al. Multiple sclerosis in childhood: clinical profile in 125 patients. The Journal of pediatrics 1987;111:359-363.

Forrester MB, Coleman L, Kornberg AJ. Multiple sclerosis in childhood: clinical and radiological features. Journal of child neurology 2009;24:56-62.

Gorman MP, Healy BC, Polgar-Turcsanyi M, Chitnis T. Increased relapse rate in pediatric-onset compared with adult-onset multiple sclerosis. Archives of neurology 2009;66:54-59.

Benson L, Healy B, Gorman M, et al. Elevated relapse rates in pediatric compared to adult MS persist for at least 6 years. Multiple sclerosis and related disorders 2014;3:186-193.

Boiko A, Vorobeychik G, Paty D, Devonshire V, Sadovnick D. Early onset multiple sclerosis: a longitudinal study. Neurology 2002;59:1006-1010.

Renoux C, Vukusic S, Mikaeloff Y, et al. Natural history of multiple sclerosis with childhood onset. New England Journal of Medicine 2007;356:2603-2613.

Amato MP, Krupp LB, Charvet LE, Penner I, Till C. Pediatric multiple sclerosis: cognition and mood. Neurology 2016;87:S82-S87.

Banwell B, Reder A, Krupp L, et al. Safety and tolerability of interferon beta-1b in pediatric multiple sclerosis. Neurology 2006;66:472-476.

Tenembaum SN, Banwell B, Pohl D, et al. Subcutaneous interferon Beta-1a in pediatric multiple sclerosis: a retrospective study. Journal of child neurology 2013;28:849-856.

Waubant E, Hietpas J, Stewart T, et al. Interferon beta-1a in children with multiple sclerosis is well tolerated. Neuropediatrics 2001;32:211-213.

Kornek B, Bernert G, Balassy C, Geldner J, Prayer D, Feucht M. Glatiramer acetate treatment in patients with childhood and juvenile onset multiple sclerosis. Neuropediatrics 2003;34:120-126.

Baroncini D, Zaffaroni M, Moiola L, et al. Long-term follow-up of pediatric MS patients starting treatment with injectable first-line agents: a multicentre, Italian, retrospective, observational study. Multiple Sclerosis Journal 2019;25:399-407.

Huppke P, Huppke B, Ellenberger D, et al. Therapy of highly active pediatric multiple sclerosis. Multiple Sclerosis Journal 2019;25:72-80.

Downloads

Publicado

04/12/2022

Como Citar

Feitosa Ribeiro , A. ., Silva Pimentel , S. K. ., Ribeiro Nascimento, A. F. ., Coelho Sousa, A. M. ., Ferreira da Silva, J. ., Maduro Bouillet, L. Érica, & Honorato, M. M. (2022). DESAFIOS NO MANEJO DA ESCLEROSE MÚLTIPLA PRECOCE EM UMA CRIANÇA COM 5 ANOS DE IDADE: RELATO DE CASO. RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 3(12), e3122247. https://doi.org/10.47820/recima21.v3i12.2247