ANTÍGENO LEUCOCITÁRIO HUMANO DE CLASSE III: REVISÃO INTEGRATIVA
DOI:
https://doi.org/10.47820/recima21.v5i3.4891Palavras-chave:
Complexo de Histocompatibilidade, Polimorfismo, Doenças, Saúde, Imunologia, GenéticaResumo
O Antígeno Leucocitário Humano de Classe III (HLA de Classe III) detém polimorfismos genéticos que se correlacionam com a etiopatogênese, suscetibilidade e gravidade de doenças que afetam os seres humanos. Objetivo: o estudo visa esclarecer o papel dos polimorfismos e as ações presentes do HLA de Classe III na sintomatologia e na patogênese de doenças crônicas, autoimunes, inflamatórias, carcinogênicas e infecciosas que afetam a humanidade. Metodologia: Trata-se de uma Revisão Integrativa, com base no acrônimo PCC e incluindo as bases de dados Biblioteca Virtual de Saúde (BVS), Capes Periódicos, Google Scholar, Embase, Medical Literature Analysis and Retrieval System Online (MEDLINE), Bibliografia Brasileira de Odontologia (BBO), ScienceDirect e Scopus. Utilizou-se como descritores termos de interesse encontrados no Medical Subject Headings (MeSH) e no Descritores das Ciências da Saúde (DeCS). Resultados: foram recuperados 56 estudos, sendo que 35 artigos de caso-controle, 3 artigos de estudo in vivo, 2 artigos de revisão de literatura, 15 artigos de estudo de coorte e 1 artigo de relato de caso. Os polimorfismos do HLA de Classe III devem-se a mutações isoladas e coordenadas com outros locus gênicos. Conclusão: os polimorfismos do HLA de Classe III podem corroborar diretamente ou indiretamente para doenças que afetam algumas populações humanas.
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