ANTÍGENO LEUCOCITÁRIO HUMANO DE CLASSE III: REVISÃO INTEGRATIVA

Autores

DOI:

https://doi.org/10.47820/recima21.v5i3.4891

Palavras-chave:

Complexo de Histocompatibilidade, Polimorfismo, Doenças, Saúde, Imunologia, Genética

Resumo

O Antígeno Leucocitário Humano de Classe III (HLA de Classe III) detém polimorfismos genéticos que se correlacionam com a etiopatogênese, suscetibilidade e gravidade de doenças que afetam os seres humanos. Objetivo: o estudo visa esclarecer o papel dos polimorfismos e as ações presentes do HLA de Classe III na sintomatologia e na patogênese de doenças crônicas, autoimunes, inflamatórias, carcinogênicas e infecciosas que afetam a humanidade. Metodologia: Trata-se de uma Revisão Integrativa, com base no acrônimo PCC e incluindo as bases de dados Biblioteca Virtual de Saúde (BVS), Capes Periódicos, Google Scholar, Embase, Medical Literature Analysis and Retrieval System Online (MEDLINE), Bibliografia Brasileira de Odontologia (BBO), ScienceDirect e Scopus. Utilizou-se como descritores termos de interesse encontrados no Medical Subject Headings (MeSH) e no Descritores das Ciências da Saúde (DeCS). Resultados: foram recuperados 56 estudos, sendo que 35 artigos de caso-controle, 3 artigos de estudo in vivo, 2 artigos de revisão de literatura, 15 artigos de estudo de coorte e 1 artigo de relato de caso. Os polimorfismos do HLA de Classe III devem-se a mutações isoladas e coordenadas com outros locus gênicos. Conclusão: os polimorfismos do HLA de Classe III podem corroborar diretamente ou indiretamente para doenças que afetam algumas populações humanas.

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Biografia do Autor

Luan Nascimento Mesquita

Universidade Federal do Pará.

Brenda Pinto de Moraes

Universidade da Amazônia.

Herika dos Santos Anijar

Escola Superior da Amazonia.

Fernanda Farias de Alcântara Marchesan

Universidade Federal do Pará.

Erika Vanessa Oliveira Jorge

Universidade Federal do Pará.

Rebeca Fontenele Pinheiro

Universidade do Estado do Pará.

Kássia Helena Silva Leitão

Universidade do Estado do Pará.

Patricia Jeanne de Souza Mendonça Mattos

Fundação Hemopa.

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Nascimento Mesquita, L., Pinto de Moraes, B., dos Santos Anijar, H., Farias de Alcântara Marchesan, F., Vanessa Oliveira Jorge, E., Fontenele Pinheiro, R., … Jeanne de Souza Mendonça Mattos, P. (2024). ANTÍGENO LEUCOCITÁRIO HUMANO DE CLASSE III: REVISÃO INTEGRATIVA. RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 5(3), e534891. https://doi.org/10.47820/recima21.v5i3.4891