RISK FACTORS LINKED TO PARKINSON'S DISEASE: A LITERATURE REVIEW
DOI:
https://doi.org/10.47820/recima21.v5i2.4906Keywords:
Parkinson's disease, risk factors, genetics, environmental factors, microbiotaAbstract
The review addresses risk factors in Parkinson's disease (PD), highlighting its multifactorial complexity and clinical implications.Objective: To synthesize recent evidence on risk factors associated with PD, explore genetic, environmental, and microbiological aspects, and discuss clinical and therapeutic implications. Methodology: This bibliographic review was conducted through a search of scientific literature published in the last 15 years, using specific inclusion and exclusion criteria. Results and Discussion: We highlight the significant contribution of genetic and environmental factors in the etiology of PD, and the emerging role of the gut microbiome. Pathogenic mechanisms, including inflammation, mitochondrial dysfunction, and proteomics, were discussed about neurodegeneration in PD. Conclusion: The importance of a personalized and holistic approach to the effective management of PD is emphasized, aiming not only to treat symptoms but also to modify modifiable risk factors to improve patient's quality of life.
Downloads
References
ASCHERIO, A.; SCHWARZSCHILD, M. A. The epidemiology of Parkinson's disease: risk factors and prevention. The Lancet Neurology, v. 15, n. 12, p. 1257-1272, 2016. DOI: https://doi.org/10.1016/S1474-4422(16)30230-7
BELIĆ, Minja et al. Artificial intelligence for assisting diagnostics and assessment of Parkinson’s disease—A review. Clinical neurology and neurosurgery, v. 184, p. 105442, 2019. DOI: https://doi.org/10.1016/j.clineuro.2019.105442
BERG, D.; POSTUMA, R. B.; BLOEM, B.; CHAN, P.; DUBOIS, B.; GASSER, T.; TOLOSA, E. Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson's disease. Movement Disorders, v. 29, n. 4, p. 454-462, 2014. DOI: https://doi.org/10.1002/mds.25844
DORSEY, E. R.; ELBAZ, A.; NICHOLS, E.; ABD-ALLAH, F.; ABDELALIM, A.; ADSUAR, J. C.; DING, E. L. Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology, v. 17, n. 11, p. 939-953, 2018.
FASANO, A.; BOVE, F.; GABRIELLI, M.; PETRACCA, M.; ZOCCO, M. A.; RAGAZZONI, E.; BENTIVOGLIO, A. R. The role of small intestinal bacterial overgrowth in Parkinson's disease. Movement Disorders, v. 28, n. 9, p. 1241-1249, 2013. DOI: https://doi.org/10.1002/mds.25522
GOLDMAN, S. M. Environmental toxins and Parkinson's disease. Annual Review of Pharmacology and Toxicology, v. 54, p. 141-164, 2014. DOI: https://doi.org/10.1146/annurev-pharmtox-011613-135937
HERMANN, W.; EGGERS, C.; TRENKWALDER, C.; FUCHS, G. Future perspectives in treating Parkinson's disease. International Journal of Neuroscience, v. 122, n. 5, p. 281-293, 2012.
KLEIN, C.; WESTENBERGER, A. Genetics of Parkinson's disease. Cold Spring Harbor Perspectives in Medicine, v. 2, n. 1, a008888, 2013. DOI: https://doi.org/10.1101/cshperspect.a008888
MARRAS, C.; BECK, J. C.; BOWER, J. H.; ROBERTS, E.; RITZ, B.; ROSS, G. W.; TANNER, C. M. Prevalence of Parkinson's disease across North America. Npj Parkinson's Disease, v. 4, n. 1, p. 1-7, 2018. DOI: https://doi.org/10.1038/s41531-018-0058-0
POEWE, W.; SEPPI, K.; TANNER, C. M.; HALLIDAY, G. M.; BRUNDIN, P.; VOLKMANN, J.; TOLOSA, E. Parkinson disease. Nature Reviews Disease Primers, v. 3, n. 1, p. 1-21, 2017. DOI: https://doi.org/10.1038/nrdp.2017.13
POSTUMA, R. B.; BERG, D.; STERN, M.; POEWE, W.; OLANOW, C. W.; OERTEL, W.; DEUSCHL, G. MDS clinical diagnostic criteria for Parkinson's disease. Movement Disorders, v. 30, n. 12, p. 1591-1601, 2015. DOI: https://doi.org/10.1002/mds.26424
PRINGSHEIM, T.; JETTE, N.; FROLKIS, A.; STEEVES, T. D. The prevalence of Parkinson's disease: a systematic review and meta-analysis. Movement Disorders, v. 29, n. 13, p. 1583-1590, 2014. DOI: https://doi.org/10.1002/mds.25945
SAMPSON, T. R.; DEBELIUS, J. W.; THRON, T.; JANSSEN, S.; SHASTRI, G. G.; ILHAN, Z. E.; KNIGHT, R. Gut microbiota regulates motor deficits and neuroinflammation in a model of Parkinson's disease. Cell, v. 167, n. 6, p. 1469-1480, 2020. DOI: https://doi.org/10.1016/j.cell.2016.11.018
SCHAPIRA, A. H.; CHAUDHURI, K. R.; JENNER, P. Non-motor features of Parkinson disease. Nature Reviews Neuroscience, v. 14, n. 3, p. 206-218, 2013.
TANNER, C. M.; GOLDMAN, S. M. Epidemiology of Parkinson's Disease. Neurologic Clinics, v. 37, n. 1, p. 1-13, 2019.
WIRDEFELDT, K.; ADAMI, H. O.; COLE, P.; TRICHOPOULOS, D. Epidemiology and etiology of Parkinson's disease: a review of the evidence. European Journal of Epidemiology, v. 26, n. 1, p. S1-S58, 2011. DOI: https://doi.org/10.1007/s10654-011-9581-6
Downloads
Published
How to Cite
License
Copyright (c) 2024 RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218
This work is licensed under a Creative Commons Attribution 4.0 International License.
Os direitos autorais dos artigos/resenhas/TCCs publicados pertecem à revista RECIMA21, e seguem o padrão Creative Commons (CC BY 4.0), permitindo a cópia ou reprodução, desde que cite a fonte e respeite os direitos dos autores e contenham menção aos mesmos nos créditos. Toda e qualquer obra publicada na revista, seu conteúdo é de responsabilidade dos autores, cabendo a RECIMA21 apenas ser o veículo de divulgação, seguindo os padrões nacionais e internacionais de publicação.
Clique para ver detalhes 
