EIXO MÚSCULO-CÉREBRO: EFICÁCIA DA SUPLEMENTAÇÃO DE CREATINA E HMB NA SARCOPENIA E NO DECLÍNIO COGNITIVO EM IDOSOS
Resumo
O envelhecimento populacional impõe desafios como a sarcopenia e o declínio cognitivo. A relação bidirecional entre músculo e cérebro sugere que intervenções nutricionais podem atuar sistemicamente. Objetivo: Analisar as evidências científicas recentes (2021-2025) sobre a eficácia da suplementação de Creatina e HMB (beta-hidroxi-beta-metilbutirato) na saúde física e mental de idosos. Metodologia: Revisão integrativa da literatura realizada nas bases PubMed, Scielo, BVS, Scopus e Web of Science. Foram selecionados oito estudos-chave, incluindo ensaios clínicos randomizados e meta-análises recentes. Resultados: A creatina demonstrou eficácia na melhora da memória e processamento cognitivo em idosos, atuando na bioenergética cerebral sob condições de estresse metabólico. O HMB evidenciou capacidade de preservação da força de preensão palmar e funcionalidade (SPPB), superando a resistência anabólica típica da idade. A suplementação combinada (Creatina + HMB) resultou em melhorias na força funcional independentes da hipertrofia, sugerindo otimização da eficiência neuromuscular. Conclusão: A suplementação combinada apresenta potencial sinérgico para mitigar a fragilidade física e cognitiva, atuando como estratégia terapêutica eficaz para a promoção da autonomia no envelhecimento.
Biografia do Autor
Graduando em Medicina (Universidade de Rio Verde - UNIRV).
Graduado em Medicina (Universidade Federal de Jataí – UFJ).
Graduado em Medicina (Universidade Federal do Piauí – UFPI).
Graduada em Nutrição (Centro Universitário Maurício de Nassau - UNINASSAU).
Graduada em Enfermagem (Universidade Nove de Julho - UNINOVE), Especialista em Pesquisas Clínicas e Estratégia Saúde da Família (DNA pós-graduação / COREN), Pós-graduanda em Reabilitação Multidisciplinar Neurofuncional Adulto (Universidade Municipal de São Caetano do Sul - USCS).
Graduada em Medicina (Universidade Federal de Jataí – UFJ).
Graduado em Medicina (Centro Universitário de Goiatuba), Pós-graduando em Neurologia (Afya Educação Médica 2025-2027), Pós-graduando em Urgência/Emergência e Intensivismo (Liberdade Médica 2026-2027).
Doutorando em Ciências da Saúde (Universidade do Sul de Santa Catarina - UNISUL).
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