A SUPEREXPRESSÃO DE miRs VIRAIS NA INFECÇÃO PELO HTLV-1, HBV E HCV CONDUZ A IMUNOPATOGÊNESE NO DESENVOLVIMENTO DO CÂNCER
Resumo
Os microRNAs (miRs) são pequenas moléculas não codificantes, consideradas excelentes biomarcadores clínicos; no entanto, são mais instáveis na circulação do que outras classes de ácidos nucleicos. A interação intrincada entre hospedeiro e vírus, ao modular a via dos miRs, geralmente promove a persistência viral ao diminuir a detecção imunológica. Para a análise de dados, foram selecionados estudos das bases de dados NCBI, BVS, LILACS e SciELO que discutem a patogênese orquestrada por miRs oncogênicos na infecção por HTLV-1, HBV e HCV. Como estratégia complementar, também foram selecionados artigos experimentais que serviram de base para a apresentação dos resultados. Foram encontrados 180 artigos, e os critérios de inclusão contemplaram estudos experimentais, ensaios controlados e revisões de literatura. Dentre esses, seis artigos experimentais foram selecionados para compor os resultados deste trabalho, por se enquadrarem nos critérios estabelecidos. Esta revisão elucidou os mecanismos moleculares associados à infecção por HTLV-1, HBV e HCV. Os resultados mostram que diversos miRs estão associados à transformação leucêmica no grupo ATL, reforçando o potencial envolvimento dessas moléculas na patogênese da ATL associada ao HTLV-1. Além disso, a regulação dessas moléculas encontra-se alterada nas infecções por HBV e HCV, nas quais esses vírus hepatotrópicos desregulam vias como NF-κB, PI3K/AKT/mTOR, TP53 e WNT, por meio de diversos mecanismos, levando a uma hepatocarcinogênese descontrolada.
Biografia do Autor
Graduado em Licenciatura em Ciências Biológicas. Especialista em Análises Clínicas e Diagnósticas. Especialista em Farmácia e em Saúde Pública. Mestre em Genética e Biologia Molecular.
Graduado em Biomedicina. Mestre e doutor em Biologia de Agentes Infecciosos e Parasitários.
Médica do Complexo Hospitalar UFPA/EBSERH. Mestra e doutora na área de Biologia dos Agentes Infecciosos e Parasitários pela UFPA. Pós-Doutora em Ciências do Ensino Superior em Saúde pela UNIFESP.
Graduada em Biomedicina. Especialista em Microbiologia. Possui Mestrado profissional em Análises Clínicas.
Graduada em Ciências Biológicas. Mestra em Biologia Parasitária na Amazônia. Doutora em Virologia.
Graduado em Fisioterapia. Mestre em Biologia de Agentes Infecciosos e Parasitários.
Graduado em Biomedicina. Especialista em Residência Multiprofissional em Atenção à Clínica Integrada.
Graduada em Medicina. Especialista em Microbiologia. Mestra em Biologia de Agentes Infecciosos e Parasitários.
Graduada em Farmácia. Mestra e doutora em Biologia de Agentes Infecciosos e Parasitários.
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