EFEITO DA TERAPIA ORTODÔNTICA SOBRE O PERFIL IMUNOLÓGICO DE INDIVÍDUOS ADULTOS EM FASE DE MANUTENÇÃO PERIODONTAL
Resumo
O interesse da população adulta na estética oral por meio da ortodontia aumentou nos últimos anos. A condição do suporte periodontal antes e durante a terapia ortodôntica é extremamente importante para verificar e identificar os pacientes suscetíveis às manifestações mais severas da doença. Assim, o objetivo deste estudo foi avaliar o efeito da terapia ortodôntica com duração de aproximadamente um ano sobre o perfil imunológico de citocinas pró-inflamatórias (INF, IL-1, IL-6) e anti-inflamatória (IL-10) de adultos em manutenção periodontal. Foram selecionados 20 indivíduos na Clínica Odontológica da Universidade UNIVERITAS UNG, sendo um grupo de indivíduos em Manutenção Periodontal (MP) e um Periodontalmente Saudável (PS). Todos receberam monitoramento clínico e imunológico. Aos 12 meses, observou-se que o grupo PS apresentou redução dos valores médios da profundidade de sondagem, do nível clínico de inserção, bem como o aumento do percentual de sítios com biofilme visível. No grupo MP, notou-se apenas redução na média do nível clínico de inserção. Os resultados imunológicos demonstraram que não houve alteração significante no grupo MP. Em relação ao grupo PS, os níveis finais de IL-10 e IL-1 foram menores do que os níveis observados no início do estudo (p<0,05, ANOVA). A IL-6 também mostrou redução dos níveis médios inicial (4,49 ± 5,80) e final (1,66 ± 1,28), porém sem diferença estatística. Em conclusão, a terapia ortodôntica, com duração de aproximadamente um ano, não alterou o perfil imunológico de citocinas pró-inflamatórias (INF, IL-1, IL-6) e anti-inflamatórias (IL-10) de indivíduos adultos em fase de manutenção periodontal.
Biografia do Autor
Docente e Coordenadora do PPG em Odontologia, UNIVERITAS-UNG, Guarulhos, SP – Brasil.
Graduação em Odontologia, Mestrado e Doutorado em Clínica Odontológica - área de concentração em Dentística pela FOP UNICAMP, Proficiência em Laser pela Academy of Laser Dentistry ALD-USA. Professor Pesquisador do PPG e Graduação em Odontologia da Universidade Guarulhos - UNG. Professor do curso de Odontologia da Universidade São Judas Tadeu - USJT. Faculty Associate do departamento Dentistry/Restorative Dental Sciences, do health Science Center da University of Florida.
Doutorado em Odontologia, UNIVERITAS-UNG, Guarulhos, SP – Brasil.
Docente UNIVERITAS-UNG, Guarulhos, SP – Brasil; Universidade São Judas Tadeu-USJT, São Paulo, SP – Brasil.
Doutorado em Odontologia, UNIVERITAS-UNG, Guarulhos, SP – Brasil.
Possui Graduação em Odontologia pela Universidade Gama Filho (1987), Especialização em Periodontia pela UNIGRANRIO (RJ), Mestrado em Odontologia (Periodontia) pela Universidade Federal do Rio de Janeiro (1993), Doutorado (Doctor in Medical Sciences) em Oral Biology pela Harvard University (1999) e Pós-Doutoramento em Microbiologia Oral pelo Forsyth Institute (1999).
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