DEMENTIA WITH LEWY BODIES: AN ANALYSIS OF PATHOLOGY, DIAGNOSIS AND THERAPEUTIC INTERVENTIONS THROUGH A LITERATURE REVIEW
DOI:
https://doi.org/10.47820/recima21.v5i2.4907Keywords:
Lewy body dementia, Pathology, Diagnosis, Therapeutic interventionsAbstract
Introduction: Dementia with Lewy bodies (DCL) is the second most common cause of neurodegenerative dementia, presenting challenges in diagnosis and clinical management due to its symptomatic complexity. Objective: This article aims to provide a comprehensive analysis of the pathology, diagnosis and therapeutic interventions in DCL. Methods: This is a bibliographic review, using articles present in the following databases: PubMed, Scopus and Web of Science. Original articles and systematic reviews in English and Portuguese published between 2015 and 2024 were included, which addressed pathology, diagnosis and therapeutic interventions in DLB. After analysis, 15 articles were selected to prepare this bibliographic review. Discussion: The clinical features of CLD were addressed, including distinctive symptoms and challenges in differential diagnosis. The pathogenesis involves mechanisms such as the formation of alpha-synuclein aggregates and synaptic dysfunction. Current therapeutic options are mainly aimed at relieving symptoms, but there are no curative treatments. Conclusion: DCL represents a challenging neurodegenerative condition, requiring early diagnosis and appropriate management to improve patients' quality of life. Continued research into biomarkers and targeted therapies is essential to advance the knowledge and treatment of DCL. Awareness and a multidisciplinary approach are key to optimizing clinical outcomes.
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