THERAPEUTIC APPROACHES IN THE MANAGEMENT OF COVID-19 IN PREGNANT WOMEN: AN INTEGRATIVE REVIEW
DOI:
https://doi.org/10.47820/recima21.v5i7.5483Keywords:
COVID-19. Pregnancy. Pharmacological treatment.Abstract
Since 2019, the global emergency of SARS-CoV-2, the cause of COVID-19, has profoundly transformed global health. Pregnant women face unique challenges due to physiological changes that increase their vulnerability to infection and complicate clinical management. This study examines therapeutic approaches for COVID-19 in pregnant women, aiming to enhance clinical practices and maternal-fetal health outcomes. The review involved 17 studies from databases such as Scielo, PubMed, and Google Scholar, focusing on identifying specific treatments. Research indicates that pregnant women do not show higher susceptibility to SARS-CoV-2 compared to the general population, emphasizing the safety of vaccination during pregnancy. Clinical management recommends the use of Personal Protective Equipment (PPE), rigorous monitoring of vital signs, and continuity of prenatal care. Normal deliveries are recommended. Treatments such as remdesivir, lopinavir/ritonavir, chloroquine, hydroxychloroquine, and azithromycin are considered, with special attention to chloroquine and hydroxychloroquine doses due to potential adverse effects. Supportive therapies such as oxygen therapy and mechanical ventilation are indicated for pregnant women with low oxygen saturation. Steroids like dexamethasone and methylprednisolone have shown efficacy in severe cases. In cases requiring hospitalization, glucocorticosteroids, low molecular weight heparin, and antibiotics should be considered. It is concluded that the treatment for pregnant women with COVID-19 follows principles similar to the general population, adapted to clinical and obstetric particularities, underscoring the need for further specific research to improve health outcomes in this vulnerable population.
Downloads
References
BORRE-NARANJO, D. et al. Infección por SARS-CoV-2 en la paciente obstétrica: una perspectiva desde el cuidado crítico. Acta Colombiana de Cuidado Intensivo, v. 20, n. 2, p. 98–107, 2020. https://doi.org/10.1016/j.acci.2020.04.002 DOI: https://doi.org/10.1016/j.acci.2020.04.002
CARDOSO, M. E. V. et al. COVID-19 na gestação: uma revisão integrativa. Revista Eletrônica Acervo Saúde, v. 12, n. 10, p. e4651, 10 out. 2020. https://doi.org/10.25248/reas.e4651.2020 DOI: https://doi.org/10.25248/reas.e4651.2020
CZERESNIA, R. M. et al. SARS-CoV-2 and Pregnancy: A Review of the Facts. Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics, v. 42, n. 09, p. 562–568, set. 2020. https://doi.org/10.1055/s-0040-1715137. DOI: https://doi.org/10.1055/s-0040-1715137
DI MASCIO, D. et al. Counseling in maternal–fetal medicine: SARS‐CoV ‐2 infection in pregnancy. Ultrasound in Obstetrics & Gynecology, v. 57, n. 5, p. 687–697, maio 2021. https://doi.org/10.1002/uog.23628 DOI: https://doi.org/10.1002/uog.23628
GODOI, A. P. N. et al. Clinical Features and Maternal-fetal Results of Pregnant Women in COVID-19 Times. Revista Brasileira de Ginecologia e Obstetrícia, v. 43, p. 384–394, 30 jul. 2021. https://doi.org/10.1055/s-0041-1729145. DOI: https://doi.org/10.1055/s-0041-1729145
GOLD, S. et al. Adapting obstetric and neonatal services during the COVID-19 pandemic: a scoping review. BMC Pregnancy Childbirthv. 22, n. 1, 11 fev. 2022. https://doi.org/10.1186/s12884-022-04409-4 DOI: https://doi.org/10.1186/s12884-022-04409-4
GONZÁLEZ-DE LA TORRE, H.; RODRÍGUEZ-RODRÍGUEZ, R.; MARTÍN-MARTÍNEZ, A. Recomendaciones y manejo práctico de la gestante con COVID-19: scoping review. Enfermería Clínica, v. 31, p. S100–S106, 1 fev. 2021. https://doi.org/10.1016/j.enfcli.2020.05.009 DOI: https://doi.org/10.1016/j.enfcli.2020.05.009
GUJSKI, M.; HUMENIUK, E.; BOJAR, I. Current State of Knowledge About SARS-CoV-2 and COVID-19 Disease in Pregnant Women. Medical Science Monitor, v. 26, 9 maio 2020. https://doi.org/10.12659/MSM.924725 DOI: https://doi.org/10.12659/MSM.924725
HASNAIN, M. et al. Protection Challenges of Pregnant Women against Vertical Transmission during COVID-19 Epidemic: A Narrative Review. American Journal of Infection Control, jul. 2020. https://doi.org/10.1016/j.ajic.2020.06.206 DOI: https://doi.org/10.1016/j.ajic.2020.06.206
JAMIESON, D. J.; RASMUSSEN, S. A. An update on COVID-19 and pregnancy. American Journal of Obstetrics and Gynecology, v. 226, n. 2, set. 2021. https://doi.org/10.1016/j.ajog.2021.08.054 DOI: https://doi.org/10.1016/j.ajog.2021.08.054
KALINKA, J. et al. COVID-19 impact on perinatal care: risk factors, clinical manifestation and prophylaxis. Polish experts’ opinion for December 2020. Ginekologia Polska, v. 92, n. 1, p. 57–63, 1 jan. 2021. https://doi.org/10.5603/GPa2021.0023 DOI: https://doi.org/10.5603/GP.a2021.0023
KHAN, D. S. A. et al. Differences in pregnancy and perinatal outcomes among symptomatic versus asymptomatic COVID-19-infected pregnant women: a systematic review and meta-analysis. BMC Pregnancy and Childbirth, v. 21, n. 1, dez. 2021. https://doi.org/10.1186/s12884-021-04250-1 DOI: https://doi.org/10.1186/s12884-021-04250-1
KRUPA, A. et al. Impact of COVID-19 on pregnancy and delivery — current knowledge. Ginekologia Polska, v. 91, n. 9, p. 564–568, 30 set. 2020. https://doi.org/10.5603/GP.a2020.0127 DOI: https://doi.org/10.5603/GP.a2020.0127
MASCARENHAS, V. H. A. et al. COVID-19 and the production of knowledge regarding recommendations during pregnancy: a scoping review. Revista Latino-Americana de Enfermagem, v. 28, 2020. https://doi.org/10.1590/1518-8345.4523.3348 DOI: https://doi.org/10.1590/1518-8345.4523.3348
MULLINS, E. et al. Coronavirus in pregnancy and delivery: rapid review. Ultrasound in Obstetrics & Gynecology, v. 55, n. 5, 17 mar. 2020. https://doi.org/10.1002/uog.22014 DOI: https://doi.org/10.1002/uog.22014
NOVOA, R. H. et al. Maternal clinical characteristics and perinatal outcomes among pregnant women with coronavirus disease 2019. A systematic review. Travel Medicine and Infectious Disease, v. 39, p. 101919, jan. 2021. https://doi.org/10.1016/j.tmaid.2020.101919 DOI: https://doi.org/10.1016/j.tmaid.2020.101919
PARUMS, D. V. Editorial: Maternal SARS-CoV-2 Infection and Pregnancy Outcomes from Current Global Study Data. Medical Science Monitor, v. 27, 5 jul. 2021. https://doi.org/10.12659/MSM.933831 DOI: https://doi.org/10.12659/MSM.933831
Downloads
Published
License
Copyright (c) 2024 RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218
This work is licensed under a Creative Commons Attribution 4.0 International License.
Os direitos autorais dos artigos/resenhas/TCCs publicados pertecem à revista RECIMA21, e seguem o padrão Creative Commons (CC BY 4.0), permitindo a cópia ou reprodução, desde que cite a fonte e respeite os direitos dos autores e contenham menção aos mesmos nos créditos. Toda e qualquer obra publicada na revista, seu conteúdo é de responsabilidade dos autores, cabendo a RECIMA21 apenas ser o veículo de divulgação, seguindo os padrões nacionais e internacionais de publicação.
