PHYSIOPATHOLOGICAL MECHANISMS AND THERAPEUTIC MANAGEMENT IN POLYCYSTIC OVARIAN SYNDROME: A BIBLIOGRAPHIC REVIEW
DOI:
https://doi.org/10.47820/recima21.v5i4.5094Keywords:
Polycystic Ovary Syndrome, Pathophysiology, TherapeuticsAbstract
Introduction: Polycystic Ovary Syndrome (PCOS) is a complex endocrine condition that affects women of reproductive age, presenting a wide range of clinical and metabolic manifestations. Objective: to analyze the pathophysiological mechanisms and therapeutic approaches of PCOS, providing an updated synthesis of the scientific literature. Methodology: This is a bibliographic review, using articles present in the following databases: PubMed, Scopus and SciELO. Original articles and systematic reviews in English and Portuguese published between 2013 and 2024 were included, which addressed pathophysiological mechanisms and therapeutic approaches to PCOS. After analysis, 37 articles were selected to prepare this bibliographic review. Results and Discussion: PCOS is a heterogeneous disease characterized by hyperandrogenism, dysfunctional ovulation and polycystic ovarian morphology, accompanied by metabolic abnormalities such as insulin resistance and obesity. Therapeutic approaches for PCOS range from pharmacological interventions to lifestyle modifications. Pharmacological treatments aim to normalize hormone levels, restore ovulation and improve clinical symptoms, including combined oral contraceptives, antiandrogens and insulin sensitizers such as metformin. Conclusion: PCOS remains a challenging condition for patients and healthcare professionals, given its pathophysiological complexity and diverse clinical manifestations.
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