PLATELET-RICH FIBRIN IN PERIODONTAL BONE REGENERATIVE TREATMENT: A SCOPE REVIEW

Abstract

Platelet concentrates are autogenous compounds obtained through high-speed centrifugation of venous blood. Within periodontal treatments, have been widely applied because of their excellent regenerative and bone neoformation properties. The present review aims to answer the following focus question: “In periodontal bone regenerative procedures, does the use of platelet rich fibrin(PRF) alone or combined with biomaterials, compared with biomaterials alone, present significant changes in bone neoformation, filling defects or dimensional gains?” A scoping review was conducted following the PRISMA-ScR statement. The Medline/pubMed, Scopus and Scielo databases were searched using key terms and looking for randomized clinical trials performed on patients with different types of periodontal bone defects, whether or not they received periodontal treatment, where it was applied in a PRF group alone or in association with biomaterials, and compared with biomaterials group alone. The electronic search generated 2,497 titles/abstracts and 5 articles were included in this review. A total of 175 volunteers were treated. The most commonly reported bone defects in the studies included presented two-or three-walls. The follow-up time for the selected studies varied between 6 and 12 months. In general, when PRF was used in the treatment of periodontal defects a more evident improvement in clinical parameters was observed, including a decrease in the depth of the defect and in probing depth and attachment gain. In conclusion, the results of this scope review indicated that the use of PRF alone or combined with biomaterials in periodontal bone regenerative procedures leads to a clinically relevant improvement in bone neoformation.