LAS FUNCIONES DE LA MICROGLÍA EN LA PROGRESIÓN DEL ASTROCITOMA - ARTÍCULO DE REVISIÓN LITERARIA
DOI:
https://doi.org/10.47820/recima21.v4i11.4286Palabras clave:
Tumor progression, astrocitom, Fenotipo M1 y M2, Mutación genética, progresión tumoralResumen
Este artículo presenta las interacciones entre el glioma conocido como astrocitoma, que tiene 4 grados de malignidad según la OMS, y la célula inmunológica cerebral microglía, así como los mecanismos mediante los cuales esta célula afecta al astrocitoma en su diferenciación fenotípica en antitumoral (M1) y protumoral (M2), así como otros factores que contribuyen a la progresión del tumor, además de las mutaciones en los genes IDH1, IDH2, TP53 y NF1 que pueden desencadenar la formación del astrocitoma. El artículo tiene como objetivo analizar la interacción entre la microglía y el astrocitoma, que es uno de los cánceres cerebrales más comunes, y cómo la célula inmunológica combate la neoplasia a través de ciertos mecanismos y contribuye a la progresión del tumor a través de otros. Como método para analizar este tema, se utilizaron libros electrónicos y artículos científicos nacionales e internacionales indexados en bases de datos como Google Académico, Scielo, PubMed, entre otros, para la elaboración de este trabajo. Los artículos seleccionados se eligieron en función de su desarrollo, resultados y discusiones sobre el tema, con información relevante para el proyecto. Tras el análisis, se pudo establecer la importancia de la mutación genética en las células presentes en la estructura cerebral para desencadenar la neoplasia a partir de la mutación de genes como NF1, IDH1 e IDH2, además de la mutación del gen TP53.
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