ESTADO NUTRICIONAL DO SELÊNIO NO CÂNCER DE MAMA: UMA REVISÃO SISTEMÁTICA E META-ANÁLISE
Resumo
O selênio é um micronutriente essencial, com ação antioxidante e papel na defesa celular, e o estado nutricional desse elemento em mulheres com câncer de mama tem despertado crescente interesse científico. Esta revisão sistemática e meta-análise avaliaram o estado nutricional de selênio em mulheres com e sem câncer de mama. A revisão foi conduzida de acordo com as diretrizes PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). O estudo buscou responder à seguinte questão norteadora: “O estado nutricional relacionado ao selênio em mulheres com câncer de mama apresenta alterações em comparação ao de mulheres sem a doença?”. A busca foi realizada nas bases de dados PubMed, Web of Science e Embase. Foram incluídos estudos que avaliaram o estado nutricional de selênio em mulheres com câncer de mama, em comparação com mulheres sem a doença. Vinte e seis artigos foram considerados elegíveis. Os níveis de selênio na dieta estavam reduzidos em mulheres com câncer de mama, em comparação com o grupo controle. Concentrações reduzidas do mineral foram encontradas no soro sanguíneo, cabelo e unhas de mulheres com câncer de mama. Os resultados em relação à atividade da enzima glutationa peroxidase foram divergentes. Os achados demonstram um estado nutricional comprometido em relação ao selênio em mulheres com câncer de mama; contudo, os resultados ainda são controversos. Isso pode ser justificado pelo complexo metabolismo do nutriente, que pode ser influenciado por alterações fisiológicas associadas ao câncer de mama.
Biografia do Autor
Mestre, Programa de Pós-Graduação em Alimentação e Nutrição, Universidade Federal do Piauí, Campus Ministro Petrônio Portela, Ininga, Teresina, Piauí, Brasil.
Mestre, Programa de Pós-Graduação em Alimentação e Nutrição, Universidade Federal do Piauí, Campus Ministro Petrônio Portela, Ininga, Teresina, Piauí, Brasil.
Doutoranda, Programa de Pós-Graduação em Nutrição em Saúde Pública, Universidade de São Paulo, São Paulo, Brasil.
Doutoranda, Programa de Pós-Graduação em Alimentação e Nutrição, Universidade Federal do Piauí, Campus Ministro Petrônio Portela, Ininga, Teresina, Piauí, Brasil.
Doutoranda, Programa de Pós-Graduação em Alimentação e Nutrição, Universidade Federal do Piauí, Campus Ministro Petrônio Portela, Ininga, Teresina, Piauí, Brasil.
Doutoranda, Programa de Pós-Graduação em Alimentação e Nutrição, Universidade Federal do Piauí, Campus Ministro Petrônio Portela, Ininga, Teresina, Piauí, Brasil.
Mestranda, Programa de Pós-Graduação em Alimentação e Nutrição, Universidade Federal do Piauí, Campus Ministro Petrônio Portela, Ininga, Teresina, Piauí, Brasil.
Mestranda, Programa de Pós-Graduação em Alimentação e Nutrição, Universidade Federal do Piauí, Campus Ministro Petrônio Portela, Ininga, Teresina, Piauí, Brasil.
Doutora, Departamento de Nutrição, Universidade Federal do Piauí, Campus Ministro Petrônio Portela, Ininga, Teresina, Piauí, Brasil.
Doutora, Departamento de Nutrição, Universidade Federal do Piauí, Campus Ministro Petrônio Portela, Ininga, Teresina, Piauí, Brasil.
Referências
ADEOTI, M. et al. Trace elements: copper, zinc and selenium in breast cancer afflicted female patients in LAUTECH Osogbo, Nigeria. Indian Journal of Cancer, v. 52, n. 1, p. 106–109, 2015.
AHMAD, A. Breast cancer metastasis and drug resistance: challenges and progress. Mobile, AL: Springer, 2019.
ALMONDES, K. G. S. et al. O papel das selenoproteínas no câncer. Revista da Associação Médica Brasileira, v. 56, p. 484–488, 2010.
ASHTON, K. et al. Methods of assessment of selenium status in humans: a systematic review. The American Journal of Clinical Nutrition, v. 89, n. 6, p. 2025S2039S, 2009.
ATUKEREN, P. et al. Variations in systemic biomarkers of oxidative/nitrosative stress and DNA damage before and during the consequent two cycles of chemotherapy in breast cancer patients. Clinical Chemistry and Laboratory Medicine, v. 48, n. 10, p. 1487–1495, 2010.
BABAKNEJAD, N. et al. The relationship between selenium levels and breast cancer: a systematic review and meta-analysis. Biological Trace Element Research, v. 159, n. 1–3, p. 1–7, 2014.
BADID, N. et al. Oxidant/antioxidant status, lipids and hormonal profile in overweight women with breast cancer. Pathology & Oncology Research, v. 16, n. 2, p. 159–167, 2010.
BASU, T. K. et al. Serum vitamins A and E, beta-carotene, and selenium in patients with breast cancer. Journal of the American College of Nutrition, v. 8, n. 6, p. 524–529, 1989.
BRASIL. Ministério da Saúde. Secretaria de Ciência, Tecnologia, Inovação e Insumos Estratégicos em Saúde. Departamento de Gestão e Incorporação de Tecnologias em Saúde. Diretrizes metodológicas: elaboração de revisão sistemática e meta-análise de ensaios clínicos randomizados. Brasília: Ministério da Saúde, 2021.
BURK, R. F.; HILL, K. E. Regulation of selenium metabolism and transport. Annual Review of Nutrition, v. 35, p. 109–134,2015.
CAI, X. et al. Selenium exposure and cancer risk: an updated meta-analysis and meta-regression. Scientific Reports, v. 6, p. 19213, 2016.
CHAITCHIK, S. et al. The distribution of selenium in human blood samples of Israeli population: comparison between normal and breast cancer cases. Biological Trace Element Research, v. 15, p. 205–212, 1988.
CHENG, J. et al. Selenium exposure on breast cancer risk and progression: comprehensive analysis identifies MSRB1 as a novel therapeutic target. Ecotoxicology and Environmental Safety, v. 302, p. 118722, 2025.
CHOI, R.; KIM, M. J.; SOHN, I. Serum trace elements and their associations with breast cancer subgroups in Korean breast cancer patients. Nutrients, v. 11, n. 1, p. 37, 2018.
CIHAN, Y. B.; SÖZEN, S.; ÖZTÜRK YILDIRIM, S. Trace elements and heavy metals in hair of stage III breast cancer patients. Biological Trace Element Research, v. 144, n. 1–3, p. 360–379, 2011.
COMBS, G. F. Biomarkers of selenium status. Nutrients, v. 7, n. 4, p. 2209–2236, 2015.
DANESH, H. et al. Association between oxidative stress parameters and hematological indices in breast cancer patients. International Journal of Breast Cancer, v. 2022, p. 1459410, 2022.
DE CICCO, P. et al. Nutrition and breast cancer: a literature review on prevention, treatment and recurrence. Nutrients, v. 11, n. 7, p. 1514, 2019.
DESANTIS, C. E. et al. Breast cancer statistics, 2015: convergence of incidence rates between black and white women. CA: A Cancer Journal for Clinicians, v. 66, n. 1, p. 31–42, 2016.
DONADIO, J. L. S.; DUARTE, G. B. S.; COZZOLINO, S. M. F. Selênio. In: COZZOLINO, S. M. F. (org.). Biodisponibilidade de nutrientes. 5. ed. Barueri, SP: Manole, 2016. p. 761–821.
DUNTAS, L. H.; BENVENGA, S. Selenium: an element for life. Endocrine, v. 48, n. 3, p. 756–775, 2015.
FERREIRA, K. S. et al. Concentrações de selênio em alimentos consumidos no Brasil. Revista Panamericana de Salud Pública, v. 11, n. 3, p. 172-177, 2002.
FLOWERS, B.; POLES, A.; KASTRATI, I. Selenium and breast cancer: an update of clinical and epidemiological data. Archives of Biochemistry and Biophysics, v. 732, p. 109465, 2022.
FONTENELLE, L. C. et al. Nutritional status of selenium in overweight and obesity: a systematic review and meta-analysis. Clinical Nutrition, v. 41, n. 4, p. 862–884, 2022.
FRANCO-MARINA, F. et al. Breast cancer age at diagnosis patterns in four Latin American populations: a comparison with North American countries. Cancer Epidemiology, v. 39, n. 6, p. 831–837, 2015.
GERBER, M. et al. Antioxidants in female breast cancer patients. Cancer Investigation, v. 9, n. 4, p. 421–428, 1991.
GHAFOOR, D. D. Correlation between oxidative stress markers and cytokines in different stages of breast cancer. Cytokine, v. 161, p. 156082, 2023.
GOSWAMI, B.; RAJAPPA, M.; GUPTA, N. Breast cancer: interaction between oxidant-antioxidant dynamics and inflammation in Indian females. Cancer Biomarkers, v. 6, n. 2, p. 95–103, 2010.
GROVER, P. L. The initiation of breast and prostate cancer. Carcinogenesis, v. 23, n. 7, p. 1095–1102, 2002.
HADI, N. A.; MAHMOOD, R. I.; AL-SAFFAR, A. Z. Evaluation of antioxidant enzyme activity in doxorubicin-treated breast cancer patients in Iraq: a molecular and cytotoxic study. Gene Reports, v. 24, p. 101285, 2021.
HECHT, F. et al. The role of oxidative stress on breast cancer development and therapy. Tumor Biology, v. 37, n. 4, p. 4281–4291, 2016.
HENRY, N. L. et al. Cancer of the breast. In: NIEDERHUBER, J. E. et al. (ed.). Abeloff’s clinical oncology. 6. ed. Philadelphia: Elsevier, p. 1560-1603,2020.
HEWALA, T. I.; ELSOUD, M. R. The clinical significance of serum oxidative stress biomarkers in breast cancer females. Medical Research Journal, v. 4, n. 1, p. 1–7, 2019.
HUANG, Y. L.; SHEU, J. Y.; LIN, T. H. Association between oxidative stress and changes of trace elements in patients with breast cancer. Clinical Biochemistry, v. 32, n. 2, p. 131–136, 1999.
HURST, R. et al. EURRECA – estimating selenium requirements for deriving dietary reference values. Critical Reviews in Food Science and Nutrition, v. 53, n. 10, p. 1077–1096, 2013.
INSTITUTE OF MEDICINE (US). Panel on Dietary Antioxidants and Related Compounds. Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. Washington, DC: National Academies Press, 2000.
INSTITUTO NACIONAL DE CÂNCER (Brasil). Incidência de câncer de mama. Rio de Janeiro: INCA, 2021. Disponível em: https://www.inca.gov.br/controle-do-cancer-de-mama/dados-e-numeros/incidencia Acesso em: 23 mar. 2021.
JAWORSKA, K. et al. Selenium and the risk of cancer of the lung and larynx: a case-control study from a region with low selenium. Hereditary Cancer in Clinical Practice, v. 10, Suppl 3, p. A7, 2012.
JOANNA BRIGGS INSTITUTE. Joanna Briggs Institute reviewers' manual: 2014 edition. Adelaide: Joanna Briggs Institute, 2014. Disponível em: https://reviewersmanual.joannabriggs.org/ Acesso em: 9 jan. 2026.
KANGARI, P.; ZARNOOSHEH, T. F.; GOLCHIN, A. Enzymatic antioxidant and lipid peroxidation evaluation in the newly diagnosed breast cancer patients in Iran. Asian Pacific Journal of Cancer Prevention, v. 19, n. 12, p. 3511–3515, 2018.
KEY, T. J. et al. Nutrition and breast cancer. Breast, v. 12, p. 412–416, 2003.
LABUNSKYY, V. M.; HATFIELD, D. L.; GLADYSHEV, V. N. Selenoproteins: molecular pathways and physiological roles. Physiological Reviews, v. 94, n. 3, p. 739–777, 2014.
LACHAT, C. et al. Strengthening the reporting of observational studies in epidemiology—nutritional epidemiology (STROBE-nut): an extension of the STROBE statement. Nutrition Bulletin, v. 41, n. 3, p. 240–251, 2016.
MENDES, P. M. V. et al. Magnesium in breast cancer: what is its influence on the progression of this disease? Biological Trace Element Research, v. 184, n. 2, p. 334–339, 2018.
MÉPLAN, C. et al. Association between polymorphisms in glutathione peroxidase and selenoprotein P genes, glutathione peroxidase activity, HRT use and breast cancer risk. PLoS ONE, v. 8, n. 9, e73316, 2013.
MOUROUTI, N. et al. Diet and breast cancer: a systematic review. International Journal of Food Sciences and Nutrition, v. 66, n. 1, p. 1–42, 2015.
MUECKE, R. et al. Multicenter, phase 3 trial comparing selenium supplementation with observation in gynecologic radiation oncology. International Journal of Radiation Oncology, Biology, Physics, v. 78, n. 3, p. 828–835, 2010.
PAGE, M. J. et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Systematic Reviews, v. 10, p. 89,2021.
PEREIRA, M. G.; GALVÃO, T. F. Heterogeneidade e viés de publicação em revisões sistemáticas. Epidemiologia e Serviços de Saúde, v. 23, n. 4, p. 775–778, 2014.
PICCININI, L. et al. A case-control study on selenium, zinc, and copper in plasma and hair of subjects affected by breast and lung cancer. Biological Trace Element Research, v. 51, n. 1, p. 23–30, 1996.
POLAT, M. F. et al. Oxidant/antioxidant status in blood of patients with malignant breast tumour and benign breast disease. Cell Biochemistry and Function, v. 20, n. 4, p. 327–331, 2002.
RAJENDRA, C. H.; KEDARI, G. S. R. Role of antioxidant levels and lipid peroxidation in patients with breast cancer. Biomedicine, v. 40, n. 2, p. 170–174,2020.
RAMÍREZ-EXPÓSITO, M. J.; SÁNCHEZ-LÓPEZ, E.; CUETO-UREÑA, C. Circulating oxidative stress parameters in pre- and post-menopausal healthy women and in women suffering from breast cancer treated or not with neoadjuvant chemotherapy. Experimental Gerontology, v. 58, p. 34–42, 2014.
RAO, C. S. S.; KUMARI, D. S. Changes in plasma lipid peroxidation and the antioxidant system in women with breast cancer. International Journal of Basic and Applied Sciences, v. 1, n. 4, p. 429–438, 2012.
RAY, G.; BATRA, S.; SHUKLA, N. K. Lipid peroxidation, free radical production and antioxidant status in breast cancer. Breast Cancer Research and Treatment, v. 59, n. 2, p. 163–170, 2000.
RAYMAN, M. P. Selenium in cancer prevention: a review of the evidence and mechanism of action. Proceedings of the Nutrition Society, v. 64, n. 4, p. 527–542, 2005.
RENKO, K. Biomarkers of Se status. In: MICHALKE, B. (ed.). Selenium. Cham: Springer, 2018. p. 451–465.
RUBINSTEIN, E.; KEYNAN, Y. Vancomycin revisited – 60 years later. Frontiers in Public Health, v. 2, p. 217, 2014.
SALEH, F. et al. Abnormal blood levels of trace elements and metals, DNA damage, and breast cancer in the state of Kuwait. Biological Trace Element Research, v. 141, n. 1–3, p. 96–109, 2011.
SALMAN, R. A.; ALBAIRUTY, G. A. A.; ABDUL-RASHEED, O. F. Decreased catalase activity and glutathione concentration levels in women patients with breast cancer. Annals of Tropical Medicine and Public Health, v. 23, n. 13, p. 231-271, 2020.
SINGH, P. et al. Association between breast cancer and vitamin C, vitamin E and selenium levels: results of a case-control study in India. Asian Pacific Journal of Cancer Prevention, v. 6, n. 2, p. 177–180, 2005.
SINHA, R.; EL-BAYOUMY, K. Apoptosis is a critical cellular event in cancer chemoprevention and chemotherapy by selenium compounds. Current Cancer Drug Targets, v. 4, n. 1, p. 13–28, 2004.
SIVAKUMAR, S.; NIRANJALI, S. D. Enzymatic and non-enzymatic antioxidant status of breast cancer patients in Tamilnadu. International Journal of Pharma and Bio Sciences, v. 2, n. 4, p. 46–53, 2011.
SUZANA, S.; CHAM, B. G.; AHMAD, G. R. Relationship between selenium and breast cancer: a case-control study in the Klang Valley. Singapore Medical Journal, v. 50, n. 3, p. 265–269, 2009.
SZWIEC, M. et al. The effect of blood selenium level on the pCR rate in breast cancer patient receiving neoadjuvant chemotherapy. Cancers, v. 17, n. 5, p. 839, 2025.
THOMSON, C. D. Assessment of requirements for selenium and adequacy of selenium status: a review. European Journal of Clinical Nutrition, v. 58, n. 3, p. 391–402, 2004.
TU, K. et al. Association of dietary intake of zinc and selenium with breast cancer risk: a case-control study in Chinese women. Nutrients, v. 15, n. 14, p. 3253, 2023.
WANG, Y. et al. Associations between dietary intake of zinc and selenium and breast cancer: findings from a NHANES cross-sectional study. Chinese Clinical Oncology, v. 14, n. 1, p. 2, 2025.
WINTERS, S. et al. Breast cancer epidemiology, prevention, and screening. Progress in Molecular Biology and Translational Science, v. 151, p. 1–32, 2017.
WU, H. I. et al. Differentiation of serum levels of trace elements in normal and malignant breast patients. Biological Trace Element Research, v. 113, n. 1, p. 9–18, 2006.
WU, Q. et al. Low population selenium status is associated with increased prevalence of thyroid disease. Journal of Clinical Endocrinology and Metabolism, v. 100, n. 11, p. 4037–4047, 2015.
YADAV, N. K. et al. Assessment of biochemical profiles in premenopausal and postmenopausal women with breast cancer. Asian Pacific Journal of Cancer Prevention, v. 13, n. 7, p. 3385–3388, 2012.
YANG, M. et al. Effects of selenium supplementation on concurrent chemoradiotherapy in patients with cervical cancer: a randomized, double-blind, placebo-parallel controlled phase II clinical trial. Frontiers in Nutrition, v. 10, p. 1094081, 2023.
YIM, G. W. et al. Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in platinum-sensitive recurrent ovarian cancer: a phase 3, double-blind, parallel group, randomized controlled pilot study. BMC Medicine, v. 24, n. 1, p. 131, 2026.
YOO, M.-H. et al. Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer’s disease. Antioxidants and Redox Signaling, v. 12, n. 7, p. 819–827, 2010.
ZAKERI, N. et al. Selenium supplementation and oxidative stress: a review. PharmaNutrition, v. 17, p. 100263, 2021.
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