CHARACTERIZATION OF HOSPITAL OUTBREAK CAUSED BY CARBAPENEMASE-PRODUCING ACINETOBACTER BAUMANNII
Abstract
Objective: to evaluate the profile of hospital outbreaks caused by carbapenemase-producing A. baumannii, in hospitals in the state of Goiás, to describe the main types of clinical samples from which the pathogen was isolated and to identify the genes that confer the production of carbapenemase encoding strains of A. baumannii of hospital outbreaks. Method: observational cross-sectional study, based on the results of bacterial isolates from hospital outbreaks caused by carbapenemase-producing A. baumannii from January 2015 to December 2020. Results: results of isolates from three hospitals were analyzed and nine outbreaks were confirmed and the resistance gene identified was blaOXA-23. Conclusion: the tracheal aspirate sample was the most frequent among hospital outbreaks and the blaOXA-23 resistance gene was identified in seven outbreaks. The characterization of the outbreaks highlights the threat posed by the spread of pathogens harboring genes encoding resistance.
Author Biographies
Especialista em Infectologia pelo Hospital de Doenças Tropicais Dr. Anuar Auad e Laboratório Estadual de Saúde Pública Dr. Giovanni Cysneiros.
Especialista em Infectologia pelo Hospital de Doenças Tropicais Dr. Anuar Auad e Laboratório Estadual de Saúde Pública Dr. Giovanni Cysneiros
Mestre em Biologia da Relação Parasito-Hospedeiro pela Universidade Federal de Goiás. Coordenadora da Biologia Médica no Laboratório Estadual de Saúde Pública Dr. Giovanni Cysneiros.
Especialista em Saúde Pública pela AVM Educacional. Biomédica no Laboratório Estadual de Saúde Pública Dr. Giovanni Cysneiros.
Doutora em Ciências da Saúde pela Universidade Federal de Goiás. Farmacêutica-BioquÃmica da Secretaria Municipal de Saúde de Goiânia. Microbiologista no Laboratório Estadual de Saúde Pública Dr. Giovanni Cysneiros.
Doutora em Ciências da Saúde pela Universidade Federal de Goiás. Biomédica do Laboratório Estadual de Saúde Pública Dr. Giovanni Cysneiros e professora da Escola de Ciências Médicas e da Vida – PontifÃcia Universidade Católica de Goiás (PUC Goiás).
References
Asif M, Alvi IA, Rehman SU. Insight into Acinetobacter baumannii: pathogenesis, global resistance, mechanisms of resistance, treatment options, and alternative modalities. Infect Drug Resist. 2018 Aug 21(11):1249-1260 DOI: https://doi.org/10.2147/IDR.S166750
Lee CR, Lee JH, Park M, Park KS, Bae IK, Kim YB et al. Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options. Front Cell Infect Microbiol. 2017 Mar 7(55):35 DOI: https://doi.org/10.3389/fcimb.2017.00055
Qi L, Li H, Zhang C, Liang B, Li J, Wang et al. Relationship between Antibiotic Resistance, Biofilm Formation, and Biofilm-Specific Resistance in Acinetobacter baumannii. Frontiers in microbiology. 2016 april, 7(483):10. doi: doi.org/10.3389/fmicb.2016.00483.
List of bacteria for which Relationship between Antibiotic Resistance, Biofilm Formation, and Biofilm-Specific Resistance in Acinetobacter baumannii new antibiotics are urgently needed [Internet]. Genebra: World Health Organization; 2017 [citado 2021 nov 08]. DisponÃvel em: https://www.who.int/news/item/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed
Makke G, Salloum T, Panossian B, Alousi S, Arabaghian H, Medvecky M et al. Whole-Genome-Sequence-Based Characterization of Extensively Drug-Resistant Acinetobacter baumannii Hospital Outbreak. MSphere, 2020 February 5(1):13. doi: https://doi.org/10.1128/mSphere.00934-19
Barletta-FarÃas R, Pérez-Ponce L, Castro-Vega G, Pujol-Pérez M, Barletta-del-Castillo J, Dueñas-Pérez Y. Acinetobacter baumannii multirresistente: un reto para la terapéutica actual. Medisur. [Internet] 2018 abr [citado 2021 dez 10]; 16(2):322-334. DisponÃvel em: en: http://www.medisur.sld.cu/index.php/medisur/article/view/3783
Brink AJ. Epidemiology of carbapenem-resistant Gram-negative infections globally. Curr Opin Infect Dis. 2019 Dez; 32(6):609-616 DOI: https://doi.org/10.1097/QCO.0000000000000608
Sinésio M, Magro M, Carneiro T, & Silva K. Fatores de risco às infecções relacionadas à assistência em unidades de terapia intensiva. Cogitare Enfermagem. 2018 abr-jun; 23(2):10. doi: http://dx.doi.org/10.5380/ce.v23i2.53826
Programa Nacional de Prevenção e Controle de Infecções Relacionadas à Assistência à Saúde (PNPCIRAS) 2021 a 2025 [Internet]. BrasÃlia: Agência Nacional de Vigilância Sanitária (ANVISA) 2021 [citado 2021 dez 18]. 61 p. DisponÃvel em: https://www.gov.br/anvisa/pt-br/centraisdeconteudo/publicacoes/servicosdesaude/publicacoes/pnpciras_2021_2025.pdf
Asadian M, Azimi L, Alinejad F, Ostadi Y, Lari AR. Molecular Characterization of Acinetobacter baumannii Isolated from Ventilator-Associated Pneumonia and Burn Wound Colonization by Random Amplified Polymorphic DNA Polymerase Chain Reaction and the Relationship between Antibiotic Susceptibility and Biofilm Production. Adv Biomed Res. 2019 Set 8(58):5 DOI: https://doi.org/10.4103/abr.abr_256_18
Tartari, DC. Rastreio, identificação e caracterização genética de Acinetobacter spp. isolados de ambiente hospitalar. [Dissertação]. Florianópolis (SC): Universidade Federal de Santa Catarina, 2016, DisponÃvel em: https://repositorio.ufsc.br/xmlui/bitstream/handle/123456789/168119/340467.pdf?sequence=1&isAllowed=y
Clark NM, Zhanel GG, Lynch JP. Emergence of antimicrobial resistance among Acinetobacter species: a global threat. Curr Opin Crit Care. 2016 Oct 22(5):491-9 DOI: https://doi.org/10.1097/MCC.0000000000000337
Hamidian M, Nigro SJ. Emergence, molecular mechanisms and global spread of carbapenem-resistant Acinetobacter baumannii. Microb Genom. 2019 Oct 5(10):13 DOI: https://doi.org/10.1099/mgen.0.000306
Chamieh A, El-Hajj G, Zmerli O, Afif C, Azar E. Carbapenem resistant organisms: A 9-year surveillance and trends at Saint George University Medical Center. J Infect Public Health. 2020 Dec 13(12):2101-2106 DOI: https://doi.org/10.1016/j.jiph.2019.02.019
Nordmann P, Poirel L. Epidemiology and Diagnostics of Carbapenem Resistance in Gram-negative Bacteria. Clin Infect Dis. 2019 Nov 69(7):521-528 DOI: https://doi.org/10.1093/cid/ciz824
Scarcella ACA, Scarcella ASA, Beretta ARZ. Infecção relacionada à assistência à saúde associada a Acinetobacter baumannii: revisão de literatura. Revista Brasileira de Análises ClÃnicas. 2017 jan 49(1):18-21 DOI: https://doi.org/10.21877/2448-3877.201600361
Módulo 5: Investigação de Eventos Adversos em Serviços de Saúde [Internet]. BrasÃlia: Agência Nacional de Vigilância Sanitária (ANVISA) 2016 [citado 2021 dez 15]. 68p. DisponÃvel em: https://proqualis.net/sites/proqualis.net/files/5%20Investiga%C3%A7%C3%A3o_de_Eventos%20em%20Servi%C3%A7os%20de%20Sa%C3%BAde.pdf
Kumari M, Batra P, Malhotra R, Mathur P. A 5-year surveillance on antimicrobial resistance of Acinetobacter isolates at a level-I trauma centre of India. J Lab Physicians. 2019 Jan-Mar 11(1):34-38 DOI: https://doi.org/10.4103/JLP.JLP_72_18
Souza LCR, Bezerra NV, Trindade EL. Aspectos epidemiológicos de Acinetobacter baumannii e avaliação do perfil de resistência em amostras biológicas de pacientes atendidos em um hospital oncológico em Belém-PA. RevSALUS - Revista CientÃfica Internacional Da Rede Académica Das Ciências Da Saúde Da Lusofonia. 2021 abr 3(1):9–55. doi: https://doi.org/10.51126/revsalus.v3i1.72
Bassetti M, Vena A, Sepulcri C, Giacobbe DR, Peghin M. Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance. Antibiotics (Basel, Switzerland). 2020 sep 9(632):18. doi: https://doi.org/10.3390/antibiotics9090632
Yu K, Zeng W, Xu Y, Liao W, Xu W, Zhou T. Bloodstream infections caused by ST2 Acinetobacter baumannii: risk factors, antibiotic regimens, and virulence over 6 years period in China. Antimicrob Resist Infect Control. 2021 jan 10(16):9. doi: https://doi.org/10.1186/s13756-020-00876-6
Metan G, Zarakolu P, Otlu B, Tekin İ, Aytaç H, Bölek EÇ et al. Emergence of colistin and carbapenem-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii (CCR-Acb) complex in a neurological intensive care unit followed by successful control of the outbreak. J Infect Public Health. 2020 Apr 13(4):564-570 DOI: https://doi.org/10.1016/j.jiph.2019.09.013
Cornejo-Juárez P, Cevallos MA, Castro-Jaimes S, Castillo-RamÃrez S, Velázquez-Acosta C, MartÃnez-Oliva D et al. High mortality in an outbreak of multidrug resistant Acinetobacter baumannii infection introduced to an oncological hospital by a patient transferred from a general hospital. PloS one, 2020 jul 15(7):14. doi: https://doi.org/10.1371/journal.pone.0234684
License
Copyright (c) 2022 RECIMA21 - Revista CientÃfica Multidisciplinar - ISSN 2675-6218
This work is licensed under a Creative Commons Attribution 4.0 International License.
Os direitos autorais dos artigos/resenhas/TCCs publicados pertecem à revista RECIMA21, e seguem o padrão Creative Commons (CC BY 4.0), permitindo a cópia ou reprodução, desde que cite a fonte e respeite os direitos dos autores e contenham menção aos mesmos nos créditos. Toda e qualquer obra publicada na revista, seu conteúdo é de responsabilidade dos autores, cabendo a RECIMA21 apenas ser o veÃculo de divulgação, seguindo os padrões nacionais e internacionais de publicação.Â