LONG NON-CODING RNAs IN GASTRIC CARCINOGENESIS
Abstract
The development of new biomarkers is essential for early detection and establishment of new therapeutic targets for Gastric Cancer (GC). Additionally, epigenetic studies reveal that long non-coding RNAs regulate gene expression at different levels, and thus may play an important role in the process of carcinogenesis, including GC pathology. Therefore, the present study aimed to investigate the relationship of some non-coding RNAs with gastric carcinogenesis. This is an integrative review, in which the bibliographic survey was carried out based on searches in the LILACS, SCIELO, PUBMED and WEB OF SCIENCE databases. The inclusion criteria for the selected articles were: articles published during the period from 2010 to 2020 and which addressed the relationship of some lRNA with gastric adenocarcinoma. The selection of articles was carried out using keywords in the evaluation of titles and abstracts identified in the initial search. The results of the studies point to new potential biomarkers or validate the effectiveness of existing lncRNAs for the clinical diagnosis of GC and future candidates for therapy targets in the treatment of the disease, since lncRNAs play an important role in regulating the expression of genes involved in the process. of cancer initiation and progression, such as tumor suppressors and oncogenes. Therefore, the mechanisms of action of lncRNAs are a potential target for discovering new biomarkers for prognosis, diagnosis and therapeutic approaches in GC.
Author Biographies
UNIESAMAZ/Professora.
UNIESAMAZ.
UNIESAMAZ.
UNIESAMAZ.
Universidade do Estado do Pará.
Universidade do Estado do Pará.
UNIESAMAZ.
UNIESAMAZ.
Núcleo de Pesquisa em Oncologia NPO.
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