ANALYSIS OF POSSIBLE CONFOUNDING BIASES IN DIAGNOSTIC TESTS FOR COVID-19 AND DENGUE: A LITERATURE REVIEW
Abstract
Covid-19, a viral disease caused by SARS-Cov-2, causes nonspecific symptoms, which can be confused with other viral infections, such as Dengue. The objective is to identify the confounding biases between the diagnostic tests for Covid-19 and dengue, as well as their possible impacts in Brazil and other countries endemic to these diseases. Material and method: A literature review was carried out in which 20 articles were selected, 14 articles from PubMED and 6 documents from the Ministry of Health and WHO, between January and July 2021. Results and discussion : There are rapid and molecular tests with different specificities and sensitivities for the diagnostic confirmation of Covid-19 and Dengue, which can present cross-reactions, causing false positives for both diseases. In view of the characteristics evaluated by the tests and the antigenic similarities of the S protein and the envelope of the Dengue virus, it is possible to consider false positives in both diseases, due to a possible cross-reaction. Final considerations: RT-PCR is the most sensitive and specific test, so ideally, more than one rapid test can also be performed for correct diagnosis.
Author Biographies
Centro Universitário de Brasília (UniCEUB).
Centro Universitário de Brasília (UniCEUB).
Centro Universitário de Brasília (UniCEUB).
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