DOPAMINERGIC RECEPTORS AND THEIR ROLE IN HUMAN MENTAL HEALTH: IMPLICATIONS FOR NEUROTRANSMISSION AND PSYCHIATRIC DISORDERS

Authors

DOI:

https://doi.org/10.47820/recima21.v6i9.6712

Keywords:

Dopamine, Receptors, Mental, Health, Neurotransmitter, Psychiatric, Disorders

Abstract

Dopamine is responsible for transmitting information from the brain to the body. It is a neurotransmitter that has five different types of receptors (D1 to D5). These dopaminergic receptors have specific functions. When there is dysregulation in their levels, it can lead to mental disorders, such as depression, manic behavior, and Parkinson's disease. The objective of the study is to analyze the influence of dopaminergic receptors, their interactions with other neurotransmitters, and how dopamine affects human mental health. To this end, an integrative literature search was carried out with the aim of conducting a bibliographic survey on dopamine receptors. The PubMed, SciELO, and LILACS databases were used. The initial search resulted in a total of 1,472 articles that passed the elimination criteria. For example, articles that did not meet the time range between 2020 and 2025 and that were not sufficiently related to the topic were eliminated. As a result, 10 articles were selected for writing. After reading these documents, the importance of dopamine and its broad effect on the neurotransmitter system became clear. Researchers are currently expanding the knowledge base on this topic, with the aim of developing new treatment methods, such as pharmacotherapy, to balance dopamine levels in the human body. Finally, this article is crucial to encourage new scientific initiatives and methods related to receptors and their influence on mental health, ensuring the well-being of the population.

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Author Biographies

  • Igor Luiz Vieira de Lima Santos

    Universidade Federal de Campina Grande, Centro de Educação e Saúde.

  • Myrelle Elias Costa

    Universidade Federal de Campina Grande, Centro de Educação e Saúde.

  • Silvânia Narielly Araújo Lima

    Universidade Federal de Pernambuco, Departamento de Ciências Farmacêuticas.

  • Aline Katiane da Silva Freire

    Universidade Federal de Campina Grande, Centro de Educação e Saúde.

  • Ana Beatriz Silva Costa

    Universidade Federal de Campina Grande, Centro de Educação e Saúde.

  • José Roberto Vaz Carneiro

    Universidade Federal de Campina Grande, Centro de Educação e Saúde.

  • Tainá Oliveira de Araújo

    Universidade Federal do Rio Grande do Norte, Faculdade de Ciências da Saúde do Trairi.

  • Carliane Rebeca Coelho da Silva

    Universidade Federal Rural de Pernambuco.

References

BASSO, P. et al. Dopamine receptor interactions and their effects in neuropsychiatric disorders. Neuroscience Research, v. 183, n. 1, p. 201-209, 2023.

BATRA, A. et al. Relationship between insulin and Netrin-1/DCC guidance cue pathway regulation in the prefrontal cortex of rodents exposed to prenatal dietary restriction. Journal of Developmental Origins of Health and Disease, v. 14, n. 4, p. 501-507, 2023.

BEAULIEU, J. M.; GAINETDINOV, R. R. The physiology, signaling, and pharmacology of dopamine receptors. Pharmacological Reviews, v. 63, n. 1, p. 182-217, 2011.

CAMPOS, L.; LOURENÇO, R. Neurociência e comportamento humano. Porto Alegre: Artmed, 2024.

CHEN, L. et al. Dopamine D2 receptor availability in major depressive disorder: insights from neuroimaging studies. Neuropsychopharmacology, v. 47, p. 1241–1250, 2022.

CHOI, W.-S. et al. Therapeutic efficacy and safety of Memantine for children and adults with ADHD with a focus on glutamate-dopamine regulation: a systematic review. The Journal of Clinical Psychiatry, v. 86, n. 1, p. 1-14, 2024.

CICCARELLI, N. et al. The role of dopamine receptors in schizophrenia and the development of antipsychotic drugs. Neuropsychiatric Disorders Journal, v. 29, n. 1, p. 124-134, 2022.

CROSSETTI, M. G. O. Revisão integrativa de pesquisa na enfermagem: o rigor científico que lhe é exigido. Revista Gaúcha de Enfermagem, v. 33, n. 2, p. 8–13, 2012.

ERCOLE, F. F.; MELO, L. S.; ALCOFORADO, C. L. G. C. Revisão integrativa versus revisão sistemática. Revista Mineira de Enfermagem, v. 18, n. 1, p. 9–11, 2014.

FALKENBERG, I. et al. Dopamine-glutamate interactions in schizophrenia: emerging evidence. Molecular Psychiatry, v. 26, p. 1345–1358, 2021.

FIORENTINI, D. et al. Dopamine dysfunction in schizophrenia: implications for therapeutic strategies. Psychiatry Research, v. 46, n. 1, p. 36-47, 2023.

FONSECA, E. et al. Antidepressant effects of essential oils: a review of the past decade (2012–2022) and molecular docking study of their major chemical components. International Journal of Molecular Sciences, v. 24, n. 11, p. 9244, 2023.

FRANK, M. J.; FOSSELLA, J. Dopamine and cognitive aging: links to executive functions. Nature Reviews Neuroscience, v. 22, p. 637–651, 2021.

GRACE, A. A. Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression. Nature Reviews Neuroscience, v. 17, n. 8, p. 524-532, 2016.

KIM, H. et al. Differential roles of dopamine D1 and D2 receptors in reward and decision-making. Brain Research Bulletin, v. 183, p. 145–153, 2022.

KLEIN, M. O. et al. Dopamine: functions, signaling, and association with neurological diseases. Cellular and Molecular Neurobiology, v. 39, n. 1, p. 31-59, 2019.

KROEMER, N. B.; MORAWETZ, C. The role of dopamine in addiction: recent advances. Current Opinion in Behavioral Sciences, v. 46, p. 101–110, 2022.

LANGE, K. et al. Dopamine receptor density and attention in ADHD. Clinical Neuroscience Journal, v. 18, n. 1, p. 103-112, 2023.

LÓPEZ-JARAMILLO, C. et al. Dopaminergic modulation in bipolar disorder: clinical and neurobiological perspectives. Bipolar Disorders, v. 25, p. 320–332, 2023.

LOUREIRO, C. M. et al. Lifetime cannabis use and childhood trauma increase risk of psychosis in carriers of CNR1 genetic variants: findings from the STREAM study. Revista Brasileira de Psiquiatria, v. 45, n. 3, p. 226-235, 2023.

MENDES, K. D. S.; SILVEIRA, R. C. C. P.; GALVÃO, C. M. Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & Contexto Enfermagem, v. 17, n. 4, p. 758–764, 2008.

MEYER, L. et al. Long-term efficacy of stimulant treatment in ADHD: dopaminergic perspectives. Journal of Child Psychology and Psychiatry, v. 62, p. 450–462, 2021.

OLIVEIRA, L. C. de. A influência da maconha (Cannabis sativa) no agravamento de doenças psiquiátricas. Revista Sociedade Científica, v. 7, n. 1, p. 2671-2699, 2024.

OSBORNE, M. et al. Non-invasive brain stimulation and dopamine: therapeutic potential. Translational Psychiatry, v. 11, p. 587–599, 2021.

PEREIRA, H. S. et al. Body self-image disturbances in women with prolactinoma. Revista Brasileira de Psiquiatria, v. 42, n. 1, p. 33-39, 2020.

PHAN, J. M.-P. et al. Hippocampal long-term potentiation is modulated by exercise-induced alterations in dopaminergic synaptic transmission in mice selectively bred for high voluntary wheel running. Restorative Neurology and Neuroscience, v. 1, n. 1, p. 1-16, 2024.

PREMI, E. et al. Early neurotransmitters changes in prodromal frontotemporal dementia: a GENFI study. Neurobiology of Disease, v. 179, n. 1, p. 1-9, 2023.

RAMEY, J. et al. Pharmacogenetics of dopamine receptors: implications for psychiatry. Pharmacogenomics Journal, v. 22, p. 412–426, 2022.

SHE, K. et al. Emerging role of microglia in the developing dopaminergic system: perturbation by early life stress. Neural Regeneration Research, v. 20, n. 1, p. 1-18, 2024.

SOARES, C. B. et al. Revisão integrativa: conceitos e métodos utilizados na enfermagem. Revista da Escola de Enfermagem da USP, v. 48, n. 2, p. 335–345, 2014.

SOUZA, M. T.; SILVA, M. D.; CARVALHO, R. Revisão integrativa: o que é e como fazer. Einstein, v. 8, n. 1, p. 102–106, 2010.

UMPIERREZ, L. S. et al. Effects of neonatal dopaminergic lesion on oral cocaine self-administration in rats: higher female vulnerability to cocaine consumption. Pharmacology Biochemistry and Behavior, v. 212, n. 1, p. 1-10, 2021.

VOLKOW, N. D.; MORALES, M. The brain on drugs: from reward to addiction. Cell, v. 162, n. 4, p. 712-725, 2015.

WANG, Y. et al. Dopamine and network-level neurotransmission in mental health. Frontiers in Neuroscience, v. 15, p. 644–653, 2021.

WHITTEMORE, R.; KNAFL, K. The integrative review: updated methodology. Journal of Advanced Nursing, v. 52, n. 5, p. 546–553, 2005.

WHOOLEY, E. et al. Dopamine genetic risk scores and psychiatric symptoms: interacting risk factors for impulse control behaviours in de novo Parkinson’s disease. Journal of Neuropsychology, v. 1, n. 1, p. 1-11, 2025.

ZHANG, Y. et al. Dopamine and motor control in Parkinson’s disease. Neurodegenerative Disease Research, v. 19, n. 1, p. 75-84, 2023.

Published

18/09/2025

How to Cite

DOPAMINERGIC RECEPTORS AND THEIR ROLE IN HUMAN MENTAL HEALTH: IMPLICATIONS FOR NEUROTRANSMISSION AND PSYCHIATRIC DISORDERS. (2025). RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 6(9), e696712. https://doi.org/10.47820/recima21.v6i9.6712