EFFECT OF PIPERINE ON MODULATING SKIN WOUND HEALING AND AS AN ANTIMICROBIAL AGENT IN VIVO: A SYSTEMATIC REVIEW OF PRECLINICAL STUDIES
Abstract
To analyze the healing and antimicrobial action of piperine on skin wounds induced in rodents. This is a systematic review conducted in Medline (via PubMed), Embase, Science Direct, and Web of Science. The following descriptors were used: piperine, wound healing, wounds, lesions, surgical wound, skin wound, antimicrobial, antibacterial agent, antifungal agent, antibacterial and antifungal, combined with the Boolean operators AND and OR. There were no restrictions on language or date of publication. The search resulted in 5,618 records, of which three studies were eligible for qualitative synthesis. In wounds infected with Staphylococcus aureus, the use of microemulsion hydrogel with piperine showed a 75.33% reduction on the 10th day of treatment, accompanied by a reduction in colony-forming units, preservation of tissue architecture, and a decrease in inflammatory infiltrate. In the Aspergillus fumigatus keratitis model, the application of piperine eye drops proved safe and reduced the clinical scores of corneal infection, fungal load, and pyroptosis markers. In excision wounds, Aloe vera gel combined with piperine achieved 80.46% retraction on the 14th day of the experiment, an effect comparable to that of sulfadiazine. The evidence indicates the potential of piperine in the treatment of skin wounds and as an antimicrobial agent. However, limitations in the consistency and quantity of studies require further investigation to confirm its efficacy and clinical safety.
Author Biographies
Graduated in Biological Sciences from the State University of Piauí (UESPI), Master's Degree in Health Biotechnology (UFCE), PhD candidate in the Graduate Program in Biotechnology (RENORBIO) – Federal University of Piauí, Teresina, Piauí, Brazil.
Nutritionist from the Federal University of Piauí (UFPI/CSHNB), PhD candidate in the Graduate Program in Biotechnology (RENORBIO) – Federal University of Piauí, Teresina, Piauí, Brazil.
Graduated in Nutrition from UFPI, Master in Health Sciences from UFPI, PhD student in the Graduate Program in Food and Nutrition (PPGAN) - Federal University of Piauí, Teresina, Piauí, Brazil.
Bachelor's degree in Chemistry from the Federal University of Piauí, Master's degree in Chemistry from the Federal University of Piauí, PhD in Biotechnology (RENORBIO), professor at UniFacid – Wyden University Centre, Teresina, Piauí, Brazil.
Technologist in Systems Analysis and Development from the Federal Institute of Piauí (IFPI), Doctor in Intellectual Property Science from the Federal University of Sergipe and master in Technologies and Management in Distance Education from the Federal Rural University of Pernambuco – UFRPE, Federal Institute of Piauí, Teresina, Piauí, Brazil.
Bachelor's degree in Chemical Engineering from the Federal University of Ceará, Master's degree in Chemistry from the University of São Paulo and PhD in Chemistry from the University of São Paulo, Department of Chemistry, Center for Natural Sciences, Federal University of Piauí, Teresina, Brazil.
Bachelor's degree in Veterinary Medicine from the Federal University of Piauí, Master's in Bioengineering from the University of Vale do Paraíba - UNIVAP and PhD in Biomedical Engineering from the University of Vale do Paraíba – UNIVAP, Center for Research in Biotechnology and Biodiversity, State University of Piauí, Teresina, Brazil.
Graduated in Nutrition, Master's degree in Physiology from the Federal University of Pernambuco, PhD in Biological Sciences from the Federal University of Pernambuco, Postdoctoral degree in Nutrition. Department of Biophysics and Physiology, Health Sciences Center, Federal University of Piauí, Teresina, Piauí, Brazil.
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