DEPRESSION IN OLDER ADULTS: PATHOPHYSIOLOGY, RISK FACTORS, AND THERAPEUTIC APPROACHES
Abstract
Population aging has contributed to an increase in depression among older adults, a prevalent condition that is frequently underdiagnosed and has a significant impact on quality of life. This study aimed to analyze the pathophysiology, risk factors, and therapeutic approaches to depression in this population. This is an integrative literature review, with a qualitative approach, conducted in the Latin American and Caribbean Health Sciences Literature and PubMed/Medline databases, including publications between 2016 and 2026, totaling 29 studies. The findings indicate that depression in older adults has a multifactorial etiology, involving neurobiological alterations and psychosocial factors. Factors such as advanced age, comorbidities, social isolation, and polypharmacy increase vulnerability. Evidence suggests greater effectiveness of combining pharmacological and non-pharmacological interventions. It is concluded that depression in older adults requires interdisciplinary and individualized management. The importance of early identification of risk factors and the integration of evidence-based therapeutic strategies is highlighted, aiming at promoting quality of life and healthy aging.
Author Biographies
Medical student at the Faculty of Medicine of Marília (FAMEMA).
Medical student at the Faculty of Medicine of Marília (FAMEMA).
Medical student at the Faculty of Medicine of Marília (FAMEMA).
Medical student at the Faculty of Medicine of Marília (FAMEMA).
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