METABOLIC SYNDROME AS A PUBLIC HEALTH PROBLEM: IMPLICATIONS FOR THE PREVENTION OF CARDIOVASCULAR DISEASES

Abstract

Metabolic syndrome is an important public health problem, characterized by the association of metabolic risk factors such as abdominal obesity, hypertension, hyperglycemia, and dyslipidemia, which significantly increase the risk of cardiovascular diseases. This study aimed to analyze the scientific evidence regarding metabolic syndrome as a public health issue and its implications for the prevention of cardiovascular diseases. This is an integrative literature review conducted in the PubMed, Virtual Health Library, SciELO, and Google Scholar databases, including studies published between 2021 and 2026 in Portuguese, English, and Spanish. The final sample consisted of eight studies selected according to eligibility criteria and rigorous analysis. The results showed that metabolic syndrome has a high global prevalence and is associated with inflammatory processes, oxidative stress, and increased cardiovascular risk. Abdominal obesity and hypertension were identified as the main associated factors and considered priorities for clinical screening. In addition, metabolic syndrome was strongly associated with cardiometabolic multimorbidity, increasing the risk of adverse outcomes and significantly impacting health systems. Evidence indicates that lifestyle modification interventions, such as regular physical activity, healthy diet, and weight control, are essential for prevention and management. It is concluded that the adoption of integrated preventive strategies, especially in primary health care, is essential to reduce cardiovascular morbidity and mortality and improve quality of life.

Author Biographies

Erislan Rodrigues Santos, Universidade Federal do Ceará

Physician in the More Doctors Program. Sobral, Ceará, Brazil.

Sâmia Vasconcelos Marques Leite, Santa Casa de Misericórdia de Sobral

Postgraduate in Neonatal Nursing from the State University of Ceará. Sobral, Ceará, Brazil.

Fabricia Costa de Oliveira

Specialist in Adult Intensive Care Nursing from the Faculty of Science and Technology of Alto Paranaíba. Sobral, Ceará, Brazil.

Fernanda Maria Gonçalves, Salute Assessoria

Master’s Degree in Health Management from the State University of Ceará. Sobral, Ceará, Brazil.

References

DOBROWOLSKI, Paweł et al. Metabolic syndrome – a new definition and management guidelines: a joint position paper. Archives of Medical Science, v. 18, n. 5, p. 1133-1156, 2022. DOI: https://doi.org/10.5114/aoms/152921

ESMAEILPOUR, M. et al. Cardiometabolic-renal multimorbidity: emerging clinical implications. Journal of Clinical Medicine, v. 15, n. 2, p. 245-259, 2026.

GÓMEZ-FERNÁNDEZ, A. et al. Adipose tissue and metabolic syndrome: role of inflammation and oxidative stress. International Journal of Molecular Sciences, v. 22, n. 8, p. 1-15, 2021.

HE, Y. et al. Dynamic changes of metabolic syndrome and risk of cardiovascular disease and mortality: a longitudinal cohort study. Journal of the American Heart Association, v. 10, n. 16, e021685, 2021.

KATZMARZYK, Peter T. et al. Physical activity, sedentary behavior, and metabolic syndrome: an updated review. Circulation, v. 145, n. 10, p. 1-13, 2022.

MACHADO, L. V. et al. Lifestyle factors and metabolic syndrome: a contemporary analysis. Revista de Saúde Pública, v. 57, p. 1-10, 2023.

MALTA, Deborah Carvalho et al. Prevalência da síndrome metabólica e fatores associados no Brasil. Revista Brasileira de Epidemiologia, v. 24, e210018, 2021.

NILSON, Eduardo A. F. et al. Economic burden of noncommunicable diseases attributable to metabolic syndrome in Brazil. The Lancet Regional Health – Americas, v. 7, p. 100158, 2022.

NOUBIAP, Jean Jacques N. et al. Global prevalence of metabolic syndrome: a systematic review and modeling analysis. Nature Communications, v. 16, p. 1-12, 2025.

O’NEILL, S.; O’DRISCOLL, L. Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies. Obesity Reviews, v. 24, n. 1, e13412, 2023.

PETERSEIM, Lukas et al. Metabolic syndrome and global health outcomes: an updated review. Journal of Primary Care & Community Health, v. 15, p. 1-10, 2024. DOI: https://doi.org/10.1177/21501319241309168

POWELL-WILEY, Tiffany M. et al. Obesity and cardiovascular disease: a scientific statement. Circulation, v. 143, n. 21, p. e984-e1010, 2021. DOI: https://doi.org/10.1161/CIR.0000000000000973

RANASINGHE, Prasad et al. Prevalence and trends of metabolic syndrome worldwide: a systematic review. International Journal of Cardiology, v. 331, p. 1-8, 2021.

ROCHLANI, Yogita et al. Metabolic syndrome: pathophysiology, management, and modulation by natural compounds. Therapeutic Advances in Cardiovascular Disease, v. 16, p. 1-15, 2022.

RODRIGUES, A. L. et al. Prevalência e componentes da síndrome metabólica em adultos atendidos em serviços de saúde. Escola Anna Nery, v. 26, n. 4, e20220123, 2022.

ROSSI, M. et al. Metabolic syndrome and cardiovascular risk: a narrative review. Nutrients, v. 14, n. 12, p. 1-15, 2022.

SAKLAYEN, Mohammad G. The global epidemic of metabolic syndrome. Current Hypertension Reports, v. 23, n. 2, p. 1-8, 2021.

SOUZA, R. F.; SILVA, A. L.; RIBEIRO, M. A. Estratégias de prevenção da síndrome metabólica na atenção primária à saúde. Revista Enfermagem em Foco, v. 13, n. 2, p. 1-8, 2022.

WORLD HEALTH ORGANIZATION. Global report on cardiovascular diseases prevention and control. Geneva: WHO, 2022.

How to Cite

Rodrigues Santos, E., Leite, S. V. M. ., Oliveira, F. C. de ., & Gonçalves, F. M. (2026). METABOLIC SYNDROME AS A PUBLIC HEALTH PROBLEM: IMPLICATIONS FOR THE PREVENTION OF CARDIOVASCULAR DISEASES. RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 7(6), e767951. https://doi.org/10.47820/recima21.v7i6.7951