EFFECT OF ORTHODONTIC THERAPY ON THE IMMUNE PROFILE OF ADULT INDIVIDUALS DURING PERIODONTAL MAINTENANCE PHASE
Abstract
Interest among adults in improving oral esthetics through orthodontic treatment has increased in recent years. The status of periodontal support before and during orthodontic therapy is critical for identifying patients susceptible to more severe periodontal breakdown. Therefore, the aim of this study was to evaluate the effect of approximately 1 year of orthodontic therapy on the immunological profile of pro-inflammatory cytokines (INF, IL-1, and IL-6) and the anti-inflammatory cytokine IL-10 in adults undergoing periodontal maintenance. Twenty individuals were recruited from the Dental Clinic of UNIVERITAS UNG University and allocated to two groups: Periodontal Maintenance (PM) and Periodontally Healthy (PH). All participants underwent clinical and immunological monitoring. After 12 months, the PH group showed reductions in mean probing depth and clinical attachment level, along with an increase in the percentage of sites with visible plaque. In the PM group, only a reduction in mean clinical attachment level was observed. Immunological findings showed no significant changes in the PM group. In the PH group, final IL-10 and IL-1 levels were lower than baseline levels (p<0.05, ANOVA). IL-6 also decreased from baseline (4.49 ± 5.80) to the final assessment (1.66 ± 1.28), although without statistical significance. In conclusion, orthodontic therapy lasting approximately 1 year did not alter the immunological profile of pro-inflammatory cytokines (INF, IL-1, and IL-6) or the anti-inflammatory cytokine IL-10 in adults undergoing periodontal maintenance.
Author Biographies
Professor and Coordinator of the Graduate Program in Dentistry, UNIVERITAS-UNG, Guarulhos, SP – Brazil.
Graduated in Dentistry (1997), Master's degree (2001), and Ph.D. (2003) in Dental Clinic - concentration area in Operative Dentistry from FOP UNICAMP, Proficiency in Laser by the Academy of Laser Dentistry ALD-USA. Research Professor in the Graduate Program and Undergraduate Dentistry at Universidade Guarulhos - UNG. Professor in the Dentistry course at Universidade São Judas Tadeu - USJT. Faculty Associate in the Dentistry/Restorative Dental Sciences department at the Health Science Center of the University of Florida. Has experience in Dental Clinic in the field of Operative Dentistry, conducting research on teeth whitening, composite resins, and dental caries.
PhD in Dentistry, Universidade Guarulhos (UNIVERITAS-UNG), Guarulhos, SP – Brazil.
Professor at Universidade Guarulhos (UNIVERITAS-UNG), Guarulhos, SP – Brazil; Universidade São Judas Tadeu (USJT), São Paulo, SP – Brazil.
PhD in Dentistry, Universidade Guarulhos (UNIVERITAS-UNG), Guarulhos, SP – Brazil.
Holds a Bachelor’s Degree in Dentistry from Universidade Gama Filho (1987), a Specialization in Periodontics from UNIGRANRIO, a Master’s Degree in Dentistry (Periodontics) from Universidade Federal do Rio de Janeiro (1993), a Doctorate (Doctor in Medical Sciences) in Oral Biology from Harvard University (1999), and a Postdoctoral Fellowship in Oral Microbiology from Forsyth Institute (1999).
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