THE RELATIONSHIP BETWEEN SPERM DNA METHYLATION AND MALE INFERTILITY: A PERSPECTIVE ON ITS USE AS A COMPLEMENTARY BIOMARKER OF THE MALE FACTOR IN CONJUGAL INFERTILITY
Abstract
This study analyzes the relationship between sperm DNA methylation and male infertility, evaluating its potential as a complementary biomarker to conventional semen analysis. To this end, it applies an integrative literature review methodology using the SciELO, PubMed, USP institutional repository, and periodical databases, limiting itself to studies in Portuguese and English published between 2010 and 2025. Fourteen articles were included after applying the eligibility criteria. Prior to analyzing the selected material, the topics of male infertility are addressed, encompassing its complexity and limitations, the basic concept of DNA methylation in relation to male fertility, and sperm DNA methylation as a biomarker of conjugal infertility. The literature reviewed found that global and gene-specific methylation negatively impact spermatogenesis and sperm DNA quality, demonstrating a relationship between epigenetic modifications and oxidative stress and other lifestyle factors, with reversibility observed through nutritional interventions and reduction of deleterious exposures. Epigenetic analysis identifies molecular defects in cases previously diagnosed as idiopathic infertility, with direct repercussions on embryonic development and offspring health. Sperm DNA methylation is understood to be a promising complementary tool for the diagnosis of conjugal infertility. However, its transition to current clinical practice is limited by the need for methodological standardization and validation of specific biomarkers.
Author Biographies
Biomedical Science student with interests in human reproduction, epigenetics, and aesthetic health. Works in the development of scientific research focused on male infertility and molecular alterations related to fertility. Has experience in the aesthetic field and an interest in integrating clinical and scientific knowledge into biomedical practice. Participates in academic productions and projects focused on health promotion and scientific innovation.
Biomedical Science undergraduate at Centro Universitário Fametro. Has academic interests in Assisted Human Reproduction, Clinical Embryology, and Laboratory Diagnostics. Participates in studies related to fertility and reproductive medicine.
Biomedical Science undergraduate at Centro Universitário Fametro. Has interests in Assisted Human Reproduction, reproductive genetics, and technologies applied to fertility. Engages in academic activities focused on scientific research in the biomedical field.
Biomedical Science undergraduate at Centro Universitário Fametro. Has interests in Assisted Human Reproduction, reproductive health, and laboratory analysis. Participates in academic projects related to the biological factors involved in human fertility.
Biomedical Science undergraduate at Centro Universitário Fametro. Has interests in Assisted Human Reproduction, embryology, and clinical diagnostics. Is dedicated to advancing knowledge in the fields of fertility and reproductive medicine.
Biomedical Science undergraduate at CEUNI – FAMETRO.
Biomedical Science undergraduate at Centro Universitário Fametro. Has interests in Assisted Human Reproduction, reproductive health, and biomedical research. Engages in studies focused on understanding the mechanisms involved in human fertility.
Biomedical Science undergraduate at Centro Universitário Fametro. Has interests in Assisted Human Reproduction, molecular biology, and laboratory diagnostics. Participates in scientific publications related to fertility and innovation in reproductive health.
PhD in Genetics, Conservation, and Evolutionary Biology from the National Institute of Amazonian Research (INPA) and Master’s in Biological Diversity from the Federal University of Amazonas (UFAM). Holds degrees in Natural Sciences and Biology, with specializations in Teaching for Professional and Technological Education, Clinical Analysis and Microbiology, and Environmental Management and Sustainability. Works in the fields of genetics, molecular biology, biological diversity, and scientific research.
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