ESTUDIO SOBRE LA INFLUENCIA DEL MATERIAL PARTICULADO FINO (PM 2,5) EN EL DESAROLLO DE NEOPLASIAS PULMONARES: UNA REVISÍON INTEGRADORA
Resumen
La contaminación atmosférica, especialmente por material particulado fino (PM2,5), representa un riesgo relevante para la salud pública, estando directamente asociada con el aumento de la incidencia y mortalidad por cáncer de pulmón. Este estudio, desarrollado mediante una revisión bibliográfica integradora, tuvo como objetivo analizar la influencia del PM2,5 en el desarrollo de neoplasias pulmonares. Se consultaron las bases de datos PubMed, BVS y SciELO, considerando publicaciones entre 2014 y marzo de 2025, en los idiomas portugués e inglés. Se aplicaron criterios de inclusión y exclusión, resultando en la selección de 10 artículos originales. Los datos analizados evidencian que la exposición crónica al PM2,5 está relacionada con el aumento del riesgo de cáncer de pulmón, incluso en concentraciones inferiores a los límites recomendados por organismos internacionales. Las poblaciones cercanas a zonas industriales, puertos y regiones afectadas por incendios forestales presentan un riesgo significativamente mayor. Estudios moleculares demuestran que el PM2,5 puede inducir alteraciones genéticas, activar vías oncogénicas, como Wnt/β-catenina, y promover metástasis, involucrando estrés oxidativo, inflamación crónica y fallas en la reparación del ADN. Se concluye que el PM₂,₅ actúa como un factor determinante en la carcinogénesis pulmonar, tanto en la inducción como en la progresión tumoral. Sus efectos se agravan con la exposición prolongada, incluso en niveles considerados seguros. Estos hallazgos refuerzan la urgencia de políticas públicas rigurosas para el control de la contaminación atmosférica.
Biografía del autor/a
Bacharel em Biomedicina.
Doutora em Farmacologia.
Bacharel em Biomedicina.
Bacharel em Biomedicina.
Bacharel em Biomedicina.
Bacharel em Biomedicina.
Bacharel em Biomedicina.
Referencias
BUSCH, P.; CIFUENTES, L. A.; CABRERA, C. Chronic exposure to fine particles (PM2.5) and mortality: evidence from Chile. Environ Epidemiol, Baltimore, v. 7, n. 4, p. e0253, 2023 DOI: https://doi.org/10.1097/EE9.0000000000000253 DOI: https://doi.org/10.1097/EE9.0000000000000253
CHEN, Y. et al. A multicenter-retrospective study of non-small-cell lung carcinoma harboring uncommon epidermal growth factor receptor (EGFR) mutations. Transl Lung Cancer Res, Hong Kong, v. 11, n. 2, p. 293-306, 2022 DOI: https://doi.org/10.21037/tlcr-21-919 DOI: https://doi.org/10.21037/tlcr-22-48
CHENG, I. et al. Traffic-related air pollution and lung cancer incidence: the California Multiethnic Cohort Study. Am J Respir Crit Care Med, New York, v. 206, n. 8, p. 1008-18, 2022 DOI: https://doi.org/10.1164/rccm.202107-1770OC DOI: https://doi.org/10.1164/rccm.202107-1770OC
CROUSE, D. L. et al. Ambient PM2.5, O3, and NO2 exposures and associations with mortality over 16 years of follow-up in the Canadian Census Health and Environment Cohort (CanCHEC). Environ Health Perspect, Research Triangle Park, v. 123, n. 11, p. 1180-6, 2015 DOI: https://doi.org/10.1289/ehp.1409276 DOI: https://doi.org/10.1289/ehp.1409276
ERHUNMWUNSEE, L. et al. The association between polluted neighborhoods and TP53-mutated non-small cell lung cancer. Cancer Epidemiol Biomarkers Prev, Philadelphia, v. 30, n. 4, p. 681-8, 2021 DOI: https://doi.org/10.1158/1055-9965.EPI-20-1555 DOI: https://doi.org/10.1158/1055-9965.EPI-20-1555
FAN, W.; XU, L.; ZHENG, H. Using multisource data to assess PM2.5 exposure and spatial analysis of lung cancer in Guangzhou, China. Int J Environ Res Public Health, Basel, v. 19, n. 5, p. 2629, 2022 DOI: https://doi.org/10.3390/ijerph19052629 DOI: https://doi.org/10.3390/ijerph19052629
FU, J. et al. An ecological analysis of PM2.5 concentrations and lung cancer mortality rates in China. BMJ Open, London, v. 5, n. 9, p. e009452, 2015 DOI: https://doi.org/10.1136/bmjopen-2015-009452 DOI: https://doi.org/10.1136/bmjopen-2015-009452
GAO, Y. et al. Wildfire-related PM2.5 and cause-specific cancer mortality. Ecotoxicol Environ Saf, Orlando, v. 258, p. 115000, 2024 DOI: https://doi.org/10.1016/j.ecoenv.2024.115000 DOI: https://doi.org/10.1016/j.celrep.2024.115000
GOODARZI, B. et al. Investigating PM2.5 toxicity in highly polluted urban and industrial areas in the Middle East: human health risk assessment and spatial distribution. Sci Rep, London, v. 13, p. 17858, 2023 DOI: https://doi.org/10.1038/s41598-023-45052-z DOI: https://doi.org/10.1038/s41598-023-45052-z
HE, Y. et al. Fine particulate matter associated mortality burden of lung cancer in Hebei Province, China. Thorac Cancer, Singapore, v. 9, n. 3, p. 297-303, 2018 DOI: https://doi.org/10.1111/1759-7714.12653 DOI: https://doi.org/10.1111/1759-7714.12653
HILL, W. et al. Lung adenocarcinoma promotion by air pollutants. Nature, London, v. 616, n. 7955, p. 12-23, 2023 DOI: https://doi.org/10.1038/s41586-023-05874-3 DOI: https://doi.org/10.1038/s41586-023-05874-3
HVIDTFELDT, U. A. et al. Long-term low-level ambient air pollution exposure and risk of lung cancer: a pooled analysis of 7 European cohorts. Environ Int, Oxford, v. 146, p. 106249, 2021 DOI: https://doi.org/10.1016/j.envint.2020.106249 DOI: https://doi.org/10.1016/j.envint.2020.106249
IIDA, M.; TAKEMOTO, K. A network biology-based approach to evaluating the effect of environmental contaminants on human interactome and diseases. Environ Health Insights, London, v. 12, p. 1178630218810160, 2018 DOI: https://doi.org/10.1177/1178630218810160 DOI: https://doi.org/10.1016/j.ecoenv.2018.05.065
INSTITUTO NACIONAL DE CÂNCER (INCA). Poluição do ar, câncer e outras doenças: o que você precisa saber? Rio de Janeiro: Ministério da Saúde, 2021. Disponível em: https://antigo.inca.gov.br/publicacoes/cartilhas/poluicao-do-arcancereoutrasdoencasoquevoceprecisa-saber Acesso em: 2 set. 2025.
JAMAL-HANJANI, M. et al. Tracking the evolution of non–small-cell lung cancer. N Engl J Med, Boston, v. 376, n. 22, p. 2237-48, 2017 DOI: https://doi.org/10.1056/NEJMoa1616288 DOI: https://doi.org/10.1056/NEJMoa1616288
LETELLIER, N. et al. The role of neighborhood air pollution exposure on somatic non-small cell lung cancer mutations in the Los Angeles Basin (2013–2018). Int J Environ Res Public Health, Basel, v. 19, n. 17, p. 11027, 2022 DOI: https://doi.org/10.3390/ijerph191711027 DOI: https://doi.org/10.3390/ijerph191711027
LI, R.; ZHOU, R.; ZHANG, J. Function of PM2.5 in the pathogenesis of lung cancer and chronic airway inflammatory diseases. Oncol Lett, Athens, v. 15, n. 5, p. 7506-14, 2018 DOI: https://doi.org/10.3892/ol.2018.8355 DOI: https://doi.org/10.3892/ol.2018.8355
MANISALIDIS, I. et al. Environmental and health impacts of air pollution: a review. Front Public Health, Lausanne, v. 8, p. 14, 2020 DOI: https://doi.org/10.3389/fpubh.2020.00014 DOI: https://doi.org/10.3389/fpubh.2020.00014
MEI, F. et al. Long-term effects of air pollutants on respiratory and cardiovascular mortality in a port city along the Adriatic Sea. BMC Pulm Med, London, v. 23, p. 135, 2023 DOI: https://doi.org/10.1186/s12890-023-02629-8 DOI: https://doi.org/10.1186/s12890-023-02629-8
NAKHARUTAI, N.; NAKHAPAKORN, K.; SASIWIMOL, S. Impact of residential concentration of PM2.5 analyzed as time-varying covariate on the survival rate of lung cancer patients: a 15-year hospital-based study in upper Northern Thailand. Int J Environ Res Public Health, Basel, v. 19, n. 8, p. 4521, 2022 DOI: https://doi.org/10.3390/ijerph19084521 DOI: https://doi.org/10.3390/ijerph19084521
ORGANIZAÇÃO MUNDIAL DA SAÚDE (OMS). Air pollution. Geneva: WHO, 2024. Disponível em: https://www.who.int/health-topics/air-pollution Acesso em: 2 set. 2025.
ORGANIZAÇÃO MUNDIAL DA SAÚDE (OMS). Health consequences of air pollution on populations. Geneva: WHO, 2024. Disponível em: https://www.who.int/news/item/25-06-2024-what-are-health-consequences-of-air-pollution-on-populations Acesso em: 2 set. 2025.
POPE, C. A. et al. Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA, Chicago, v. 287, n. 9, p. 1132-41, 2002 DOI: https://doi.org/10.1001/jama.287.9.1132 DOI: https://doi.org/10.1001/jama.287.9.1132
SHI, Y. et al. PM2.5-induced alteration of DNA methylation and RNA-transcription are associated with inflammatory response and lung injury. Sci Total Environ, Amsterdam, v. 650, p. 2142-50, 2019 DOI: https://doi.org/10.1016/j.scitotenv.2018.09.085 DOI: https://doi.org/10.1016/j.scitotenv.2018.09.085
SINGH, T. et al. Exploring the relationship between air quality index and lung cancer mortality in India: predictive modeling and impact assessment. Sci Rep, London, v. 13, p. 17994, 2023 DOI: https://doi.org/10.1038/s41598-023-47705-5 DOI: https://doi.org/10.1038/s41598-023-47705-5
SOUZA, M. T.; SILVA, M. D.; CARVALHO, R. Revisão integrativa: o que é e como fazer. Einstein (São Paulo), São Paulo, v. 8, n. 1, p. 102-6, 2010 DOI: https://doi.org/10.1590/s1679-45082010rw1134 DOI: https://doi.org/10.1590/s1679-45082010rw1134
THANDRA, K. C. et al. Epidemiology of lung cancer. Contemp Oncol (Pozn), Poznan, v. 25, n. 1, p. 45-52, 2021 DOI: https://doi.org/10.5114/wo.2021.103829 DOI: https://doi.org/10.5114/wo.2021.103829
VLASSCHAERT, C. et al. Clonal hematopoiesis of indeterminate potential-associated non-small cell lung cancer risk is potentiated by small particulate matter air pollution among non-smokers: a novel somatic variant–environment interaction. MedRxiv, Cold Spring Harbor, 2024 DOI: https://doi.org/10.1101/2024.01.17.24301439 DOI: https://doi.org/10.1101/2024.01.17.24301439
WANG, T. H. et al. PM2.5 promotes lung cancer progression through activation of the AhR-TMPRSS2-IL18 pathway. EMBO Mol Med, Hoboken, v. 15, n. 6, p. e17014, 2023 DOI: https://doi.org/10.15252/emmm.202217014 DOI: https://doi.org/10.15252/emmm.202217014
WANG, Y. et al. Air pollution in heavy industrial cities along the northern slope of the Tianshan Mountains, Xinjiang: characteristics, meteorological influence, and sources. Environ Sci Pollut Res Int, Berlin, v. 30, n. 46, p. 100484-500, 2023 DOI: https://doi.org/10.1007/s11356-023-25757-0
WU, X. et al. The epidemiological trends in the burden of lung cancer attributable to PM2.5 exposure in China. BMC Public Health, London, v. 21, n. 1, p. 1-10, 2021 DOI: https://doi.org/10.1186/s12889-021-10765-1 DOI: https://doi.org/10.1186/s12889-021-10765-1
XU, J. et al. CircCDR1as mediates PM2.5-induced lung cancer progression by binding to SRSF1. Ecotoxicol Environ Saf, Orlando, v. 249, p. 114367, 2023 DOI: https://doi.org/10.1016/j.ecoenv.2022.114367 DOI: https://doi.org/10.1016/j.ecoenv.2022.114367
YU, H. et al. Exosomes from PM2.5-treated human bronchial epithelial cells increase lung cancer metastatic potential. Biomed Environ Sci, Beijing, v. 35, n. 6, p. 491-500, 2022 DOI: https://doi.org/10.3967/bes2022.066
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