EJE MÚSCULO-CEREBRO: EFICACIA DE LA SUPLEMENTACIÓN CON CREATINA Y HMB EN LA SARCOPENIA Y EL DETERIORO COGNITIVO EN ANCIANOS
Resumen
El envejecimiento de la población plantea retos críticos como la sarcopenia y el deterioro cognitivo. La relación bidireccional entre el músculo y el cerebro sugiere que las intervenciones nutricionales pueden actuar de forma sistémica mediante el denominado eje músculo-cerebro. Objetivo: Analizar la evidencia científica reciente (2021-2025) sobre la eficacia de la suplementación con creatina e HMB en la salud física y mental de los ancianos. Metodología: Se realizó una revisión integradora de la literatura en las bases de datos PubMed/MEDLINE, LILACS/BVS y Scielo. Se seleccionaron ocho estudios clave, incluyendo ensayos clínicos aleatorizados y metaanálisis recientes. Resultados: La creatina demostró eficacia en la mejora de la memoria y el procesamiento cognitivo, actuando sobre la bioenergética cerebral en condiciones de estrés metabólico. El HMB evidenció capacidad para preservar la fuerza de prensión manual y la funcionalidad, superando la resistencia anabólica típica de la edad. La suplementación combinada creatina y HMB dio lugar a mejoras en la fuerza funcional mediante la optimización de la eficiencia neuromuscular, independientemente de la hipertrofia muscular. Conclusión: Esta combinación presenta un potencial sinérgico para mitigar la fragilidad física y cognitiva, siendo una estrategia terapéutica eficaz para promover la autonomía en la vejez.
Biografía del autor/a
Graduando em Medicina (Universidade de Rio Verde - UNIRV).
Graduado em Medicina (Universidade Federal de Jataí – UFJ).
Graduado em Medicina (Universidade Federal do Piauí – UFPI).
Graduada em Nutrição (Centro Universitário Maurício de Nassau - UNINASSAU).
Graduada em Enfermagem (Universidade Nove de Julho - UNINOVE), Especialista em Pesquisas Clínicas e Estratégia Saúde da Família (DNA pós-graduação / COREN), Pós-graduanda em Reabilitação Multidisciplinar Neurofuncional Adulto (Universidade Municipal de São Caetano do Sul - USCS).
Graduada em Medicina (Universidade Federal de Jataí – UFJ).
Graduado em Medicina (Centro Universitário de Goiatuba), Pós-graduando em Neurologia (Afya Educação Médica 2025-2027), Pós-graduando em Urgência/Emergência e Intensivismo (Liberdade Médica 2026-2027).
Doutorando em Ciências da Saúde (Universidade do Sul de Santa Catarina - UNISUL).
Referencias
ANTONIO, J. et al. Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? Journal of the International Society of Sports Nutrition, v. 18, n. 1, p. 13, 2021. https://doi.org/10.1186/s12970-021-00412-w DOI: https://doi.org/10.1186/s12970-021-00412-w
AROSIO, B. et al. Sarcopenia and cognitive decline in older adults: targeting the muscle-brain axis. Nutrients, v. 15, n. 8, p. 1853, abr. 2023. https://doi.org/10.3390/nu15081853 DOI: https://doi.org/10.3390/nu15081853
BIAN, X. et al. Evidence suggesting creatine as a new central neurotransmitter: presence in synaptic vesicles, release upon stimulation, effects on cortical neurons and uptake into synaptosomes and synaptic vesicles. eLife, v. 12, p. RP89317, 2023. https://doi.org/10.7554/eLife.89317.4 DOI: https://doi.org/10.7554/eLife.89317.1
BIDESHKI, M. V. et al. Ergogenic benefits of β-hydroxy- β-methylbutyrate (HMB) supplementation on body composition and muscle strength: a comprehensive review of meta-analyses. Journal of Cachexia, Sarcopenia and Muscle, v. 16, 2025. https://doi.org/10.1002/jcsm.13654 DOI: https://doi.org/10.1002/jcsm.13671
COUREL-IBÁÑEZ, J. et al. Health benefits of β-hydroxy- β-methylbutyrate (HMB) supplementation in addition to physical exercise in older adults: a systematic review with meta-analysis. Nutrients, v. 11, n. 9, p. 2082, 2019. https://doi.org/10.3390/nu11092082 DOI: https://doi.org/10.3390/nu11092082
CUI, D. et al. A novel voluntary weightlifting model in mice promotes muscle adaptation and insulin sensitivity with simultaneous enhancement of autophagy and mTOR pathway. The FASEB Journal, v. 34, n. 6, p. 7330-7344, 2020. https://doi.org/10.1096/fj.201903055R DOI: https://doi.org/10.1096/fj.201903055R
DE FREITAS, G. B. et al. Protective actions of exercise-related FNDC5/Irisin in memory and Alzheimer's disease. Journal of Neurochemistry, v. 155, n. 6, p. 602-611, 2020. https://doi.org/10.1111/jnc.15039 DOI: https://doi.org/10.1111/jnc.15039
FERNÁNDEZ-LANDA, J. et al. Effect of ten weeks of creatine monohydrate plus HMB supplementation on athletic performance tests in elite male endurance athletes. Nutrients, v. 12, n. 1, p. 193, 2020. https://doi.org/10.3390/nu12010193 DOI: https://doi.org/10.3390/nu12010193
FORBES, S. C. et al. Changes in fat mass following creatine supplementation and resistance training in adults ≥ 50 years of age: a meta-analysis. Journal of Functional Morphology and Kinesiology, v. 4, n. 3, p. 62, 2019. https://doi.org/10.3390/jfmk4030062 DOI: https://doi.org/10.3390/jfmk4030062
GARCÍA-ALONSO, A. et al. The role of HMB supplementation in potentiating the effects of resistance training in older adults: a systematic review and meta-analysis on muscle quality, body composition, and physical function. Nutrients, v. 17, n. 22, p. 3624, 2025. https://doi.org/10.3390/nu17223624 DOI: https://doi.org/10.3390/nu17223624
HAM, D. J. et al. The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia. Nature Communications, v. 11, n. 1, p. 4510, 2020. https://doi.org/10.1038/s41467-020-18140-1 DOI: https://doi.org/10.1038/s41467-020-18140-1
KIM, J. Handgrip strength to predict the risk of all-cause mortality and premature death in Korean adults: a 10-year cohort study. International Journal of Environmental Research and Public Health, v. 19, n. 1, p. 39, 2021. https://doi.org/10.3390/ijerph19010039 DOI: https://doi.org/10.3390/ijerph19010039
LOURENÇO, M. V. et al. Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models. Nature Medicine, v. 25, n. 1, p. 165-175, 2019. https://doi.org/10.1038/s41591-018-0275-4 DOI: https://doi.org/10.1038/s41591-018-0275-4
OLIVEIRA, E. F. et al. Association between dietary creatine and short-term visuospatial memory in elderly. Nutrition and Health, v. 29, p. 731–736, 2023. https://doi.org/10.1177/02601060221102273 DOI: https://doi.org/10.1177/02601060221102273
POLO-FERRERO, L. et al. Effectiveness of resistance training in sarcopenic obesity in community-dwelling older women: a randomized controlled trial. Nutrients, v. 17, p. 1822, 2025. https://doi.org/10.3390/nu17111822 DOI: https://doi.org/10.3390/nu17111822
RAMOS-HERNÁNDEZ, R. et al. Combined creatine and HMB supplementation improves functional strength independent of muscle mass in physically active older adults: a randomized crossover trial. GeroScience, 2025. https://doi.org/10.1007/s11357-025-01889-y DOI: https://doi.org/10.1007/s11357-025-01889-y
ROSCHEL, H. et al. Creatine supplementation and brain health. Nutrients, v. 13, n. 2, p. 586, 2021. https://doi.org/10.3390/nu13020586 DOI: https://doi.org/10.3390/nu13020586
SANDKÜHLER, J. F. et al. The effects of creatine supplementation on cognitive performance — a randomised controlled study. BMC Medicine, v. 21, p. 440, 2023. https://doi.org/10.1186/s12916-023-03146-5 DOI: https://doi.org/10.1186/s12916-023-03146-5
SEVERINSEN, M. C. K.; PEDERSEN, B. K. Muscle-organ crosstalk: the emerging roles of myokines. Endocrine Reviews, v. 41, n. 4, p. 594-609, 2020. https://doi.org/10.1210/endrev/bnaa016 DOI: https://doi.org/10.1210/endrev/bnaa016
SMOLAREK, A. C. et al. Effect of 16 weeks of strength training and creatine supplementation on strength and cognition in the elderly: a pilot study. Journal of Exercise Physiology Online, v. 23, n. 4, p. 88–94, 2020. https://www.asep.org/asep/asep/JEPonlineAUGUST2020_Smolarek.pdf
SU, H. et al. The effects of β-hydroxy-β-methylbutyrate or HMB-rich nutritional supplements on sarcopenia patients: a systematic review and meta-analysis. Frontiers in Medicine, v. 11, p. 1348212, 2024. https://doi.org/10.3389/fmed.2024.1348212 DOI: https://doi.org/10.3389/fmed.2024.1348212
TEZZE, C.; SANDRI, M.; TESSARI, P. Anabolic resistance in the pathogenesis of sarcopenia in the elderly: role of nutrition and exercise in young and old. Nutrients, v. 15, n. 18, p. 4073, 2023. https://doi.org/10.3390/nu15184073 DOI: https://doi.org/10.3390/nu15184073
TØIEN, T. et al. Heavy strength training in older adults: implications for health, disease, and physical function. Journal of Cachexia, Sarcopenia and Muscle, v. 16, n. 2, p. e130804, 2025. https://doi.org/10.1002/jcsm.13804 DOI: https://doi.org/10.1002/jcsm.13804
XU, C. et al. The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis. Frontiers in Nutrition, v. 11, p. 1424972, 2024. https://doi.org/10.3389/fnut.2024.1424972 DOI: https://doi.org/10.3389/fnut.2024.1424972
YANG, C. et al. Effects of β-Hydroxy- β-Methylbutyrate Supplementation on Older Adults with Sarcopenia: A Randomized, Double-Blind, Placebo-Controlled Study. The Journal of Nutrition, Health & Aging, v. 27, p. 329-339, 2023. https://doi.org/10.1007/s12603-023-1911-1 DOI: https://doi.org/10.1007/s12603-023-1911-1
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