EFEITOS DO EXERCÍCIO FÍSICO SOBRE SINTOMAS DE ANSIEDADE E DEPRESSÃO EM ADULTOS: REVISÃO SISTEMÁTICA E META-ANÁLISESTEMÁTICA E META-ANÁLISE

Resumo

Objetivo: Avaliar os efeitos do exercício físico regular, com ênfase no componente aeróbico, sobre os sintomas de ansiedade e depressão em adultos. Metodologia: Trata-se de uma revisão sistemática com meta-análise, conduzida conforme as diretrizes PRISMA e registrada no PROSPERO. A busca foi realizada nas bases Medline/PubMed, BVS e PEDro, abrangendo ensaios clínicos randomizados publicados entre 2020 e 2025. A qualidade metodológica foi avaliada pela ferramenta RoB 2.0. A síntese quantitativa empregou modelos de efeitos aleatórios e análise de subgrupos via software RStudio. Resultados: Foram incluídos 12 estudos totalizando intervenções variadas (aeróbico, resistido, caminhada e práticas integrativas). A meta-análise revelou alta heterogeneidade (I2 = 98,1). Embora o modelo de efeito comum tenha indicado benefício global favorável (SMD = 0,74; IC 95% [0,63; 0,85]), o modelo de efeitos aleatórios não sustentou significância estatística global (p > 0,05), embora subgrupos de intervenções de curto prazo e de baixa intensidade tenham demonstrado efeitos positivos consistentes. Conclusão: O exercício físico atua como uma estratégia terapêutica complementar relevante, promovendo melhora na saúde mental e física. Contudo, a alta variabilidade entre protocolos sugere a necessidade de prescrições individualizadas e estudos com maior padronização metodológica.

Biografia do Autor

Ana Vitória Cabral Holanda, Centro Universitário Mauricio de Nassau

Graduando em Fisioterapia pelo Centro Universitário Mauricio de Nassau, Mossoró - RN

Ana Heloisa Costa Freitas, Centro Universitário Mauricio de Nassau

Graduando em Fisioterapia pelo Centro Universitário Mauricio de Nassau, Mossoró - RN

Jennifer Kelly Cirilo Vieira, Centro Universitário Mauricio de Nassau

Graduando em Fisioterapia pelo Centro Universitário Mauricio de Nassau, Mossoró - RN.

Salvador Viana Gomes Junior, Centro Universitário Mauricio de Nassau

Doutorando em Ciências Fisiológicas pela Sociedade Brasileira de Fisiologia - SBFis sediado na Universidade do Estado do Rio Grande do Norte - UERN. Mestre em Saúde e Sociedade pela Universidade do Estado do Rio Grande do Norte - UERN (2015). Especialista em Atendimento Pré-Hospitalar (2015) e Terapia Intensiva (2014) e em Citologia Clínica (2020). Biomédico com habilitação em patologia clínica pela Faculdade de Medicina Nova Esperança-FACENE (2018); Graduado em Fisioterapia pela Universidade Potiguar (2012), Coordenador Acadêmico do Curso de Fisioterapia da Faculdade Maurício de Nassau-Uninassau Campus Mossoró. 

Referências

Alegría, M., et al. (2018). Social determinants of mental health: Where we are and where we need to go. Current Psychiatry Reports, 20(11), 95. DOI: https://doi.org/10.1007/s11920-018-0969-9

Amoozadeh, Z., et al. (2025). Assessment the relationship between health anxiety and Iranian nurses’ quality of life: A cross-sectional study. Frontiers in Psychiatry, 16. https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1447816/full DOI: https://doi.org/10.3389/fpsyt.2025.1447816

Banyard, H., et al. (2025). The effects of aerobic and resistance exercise on depression and anxiety: Systematic review with meta-analysis. International Journal of Mental Health Nursing, 34(3), e70054. DOI: https://doi.org/10.1111/inm.70054

de Souza, L. N., de Araújo, S. M., da Silva Paiva, E., da Silva, A. E., da Costa Neto, J. F., Lima de Assis, J. C., & et al. (2025). Effectiveness of aerobic physical exercise on depression symptoms in adults: A protocol for developing a systematic review and meta-analysis of randomized clinical trials. PLoS ONE, 20(6), Artigo e0314846. DOI: https://doi.org/10.1371/journal.pone.0314846

Dempsey, P. C., et al. (2020). New global guidelines on sedentary behaviour and health for adults: Broadening the behavioural targets. International Journal of Behavioral Nutrition and Physical Activity, 17(1), 151. DOI: https://doi.org/10.1186/s12966-020-01044-0

Ganz, A. B., Rolnik, B., Chakraborty, M., Wilson, J., Tau, C., Sharp, M., Reber, D., Slavich, G. M., & Snyder, M. P. (2022). Effects of an immersive psychosocial training program on depression and well-being: A randomized clinical trial. Journal of Psychiatric Research, 150, 292–299. DOI: https://doi.org/10.1016/j.jpsychires.2022.02.034

Große, J., Huppertz, C., Röh, A., Oertel, V., Andresen, S., Schade, N., Goerke-Arndt, F., Kastinger, A., Schoofs, N., Thomann, P. A., Henkel, K., Malchow, B., Plag, J., Terziska, A., Brand, R., Helmig, F., Schorb, A., Wedekind, D., Jockers-Scherübl, M., Schneider, F., Petzold, M. B., & Ströhle, A. (2024). Step away from depression—results from a multicenter randomized clinical trial with a pedometer intervention during and after inpatient treatment of depression. European Archives of Psychiatry and Clinical Neuroscience, 274(4), 709–721. DOI: https://doi.org/10.1007/s00406-023-01646-2

Hah, J. M., et al. (2021). Return to work and productivity loss after surgery: A health economic evaluation. International Journal of Surgery, 95, 106100. DOI: https://doi.org/10.1016/j.ijsu.2021.106100

Higham, S. M., Mendham, A. E., Rosenbaum, S., Allen, N. G., Smith, G., & Duffield, R. (2025). Effect of concurrent exercise training on stress, depression and anxiety in inactive academics: Secondary analysis of a randomized controlled trial. Research Quarterly for Exercise and Sport, 96(3), 563–572. DOI: https://doi.org/10.1080/02701367.2025.2461322

Hopwood, M. (2023). Anxiety symptoms in patients with major depressive disorder: Commentary on prevalence and clinical implications. Neurology and Therapy, 12(Suppl 1), 5–12. DOI: https://doi.org/10.1007/s40120-023-00469-6

Latimer, K., Larok, R., Nyeko, J. P., Murungi, L., Luwangula, R., Lukungu, B., Carrin, J., Nannungi, R., Comboni, D. O., Kalule, E. N., Rosenbaum, S., & Vancampfort, D. (2025). A sport-for-protection program reduces anxiety and depression in youth affected by displacement: A randomized controlled trial of the Game Connect program in Uganda. Journal of Affective Disorders, 376, 84–91. DOI: https://doi.org/10.1016/j.jad.2025.02.001

Lee, Y. H., Kim, H., Hwang, J., & Noh, S. (2024). Effectiveness of mobile-based progressive and fixed physical activity on depression, stress, anxiety, and quality of life outcomes among adults in South Korea: Randomized controlled trial. JMIR mHealth and uHealth, 12, Artigo e55578. DOI: https://doi.org/10.2196/55578

Linares-Espinós, E., et al. (2018). Methodology of a systematic review. Actas Urológicas Españolas, 42(8), 499–506. DOI: https://doi.org/10.1016/j.acuroe.2018.07.002

Liu, R., Menhas, R., & Saqib, Z. A. (2024). Does physical activity influence health behavior, mental health, and psychological resilience under the moderating role of quality of life? Frontiers in Psychology, 15, 1349880. DOI: https://doi.org/10.3389/fpsyg.2024.1349880

Liu, X., et al. (2024). Effects of aerobic exercise combined with resistance training on body composition and metabolic health in children and adolescents with overweight or obesity: Systematic review and meta-analysis. Frontiers in Public Health, 12, 1409660. DOI: https://doi.org/10.3389/fpubh.2024.1409660

Melo, A. P. S., et al. (2022). All-cause and cause-specific mortality among people with severe mental illness in Brazil’s public health system, 2000–15: A retrospective study. The Lancet Psychiatry, 9(10), 771–781. DOI: https://doi.org/10.1016/S2215-0366(22)00237-1

Mubarak, N., et al. (2023). Examining the tapestry of mental health crises in low- and middle-income countries: An intercontinental analysis of the contributing factors and instructive approaches. Journal of University Medical & Dental College, 14(4). https://www.jumdc.com/index.php/jumdc/article/view/972 DOI: https://doi.org/10.37723/jumdc.v14i4.972

Noetel, M., Sanders, T., Gallardo-Gómez, D., Taylor, P., del Pozo Cruz, B., van den Hoek, D., Smith, J. J., Mahoney, J., Spathis, J., Moresi, M., Pagano, R., Pagano, L., Vasconcellos, R., Arnott, H., Varley, B., Parker, P., Biddle, S., & Lonsdale, C. (2024). Effect of exercise for depression: Systematic review and network meta-analysis of randomised controlled trials. BMJ, 384, Artigo e075847. DOI: https://doi.org/10.1136/bmj-2023-075847

Nowacka-Chmielewska, M., et al. (2022). Running from stress: Neurobiological mechanisms of exercise-induced stress resilience. International Journal of Molecular Sciences, 23(21), 13348. DOI: https://doi.org/10.3390/ijms232113348

O'Sullivan, D., Gordon, B. R., Lyons, M., Meyer, J. D., & Herring, M. P. (2023). Effects of resistance exercise training on depressive symptoms among young adults: A randomized controlled trial. Psychiatry Research, 326, Artigo 115322. DOI: https://doi.org/10.1016/j.psychres.2023.115322

Ouzzani, M., et al. (2016). Rayyan—a web and mobile app for systematic reviews. Systematic Reviews, 5(1), 210. DOI: https://doi.org/10.1186/s13643-016-0384-4

Page, M. J., et al. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. Systematic Reviews, 10(1), 89. DOI: https://doi.org/10.1186/s13643-021-01626-4

Peçanha, A., et al. (2025). Can social isolation alleviate symptoms of anxiety and depression disorders? Frontiers in Psychiatry, 16. https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1561916/full DOI: https://doi.org/10.3389/fpsyt.2025.1561916

Pérez-Solà, V., et al. (2021). Economic impact of treatment-resistant depression: A retrospective observational study. Journal of Affective Disorders, 295, 578–586. DOI: https://doi.org/10.1016/j.jad.2021.08.036

Remes, O., Mendes, J. F., & Templeton, P. (2021). Biological, psychological, and social determinants of depression: A review of recent literature. Brain Sciences, 11(12), 1633. DOI: https://doi.org/10.3390/brainsci11121633

Remiszewski, M., Rajtar, G., Komarek, Z., Pałka, T., Maciejczyk, M., & Ligeza, T. S. (2025). Long-term aerobic exercise enhances interoception and reduces symptoms of depression and anxiety in physically inactive young adults: A randomized controlled trial. Psychology of Sport & Exercise, 81, Artigo 102939. DOI: https://doi.org/10.1016/j.psychsport.2025.102939

Sterne, J. A. C., et al. (2019). RoB 2: A revised tool for assessing risk of bias in randomised trials. BMJ, 366, l4898. DOI: https://doi.org/10.1136/bmj.l4898

Thaller, L., Frühauf, A., Heimbeck, A., Voderholzer, U., & Kopp, M. (2022). A comparison of acute effects of climbing therapy with Nordic walking for inpatient adults with mental health disorder: A clinical pilot trial. International Journal of Environmental Research and Public Health, 19(11), Artigo 6767. DOI: https://doi.org/10.3390/ijerph19116767

Ursi, E. S., & Galvão, C. M. (2006). Prevenção de lesões de pele no perioperatório: Revisão integrativa da literatura. Revista Latino-Americana de Enfermagem, 14(1), 124–131. DOI: https://doi.org/10.1590/S0104-11692006000100017

Verhoeven, J. E., Han, L. K. M., Lever-van Milligen, B. A., Hu, M. X., Révész, D., Hoogendoorn, A. W., Batelaan, N. M., van Schaik, D. J. F., van Balkom, A. J. L. M., van Oppen, P., & Penninx, B. W. J. H. (2023). Antidepressants or running therapy: Comparing effects on mental and physical health in patients with depression and anxiety disorders. Journal of Affective Disorders, 329, 19–29. DOI: https://doi.org/10.1016/j.jad.2023.02.064

Vreijling SR, Penninx BWJH, Verhoeven JE, Teunissen CE, Blujdea ER, Beekman ATF, Lamers F, Jansen R. Running therapy or antidepressants as treatments for immunometabolic depression in patients with depressive and anxiety disorders: A secondary analysis of the MOTAR study. Brain Behav Immun. 2025 Jan;123:876-883. DOI: https://doi.org/10.1016/j.bbi.2024.10.033

Wang, Z., Zhang, Z., & Wu, Y. (2024). The effects of Baduanjin exercise on the psychological condition and heart rate variability of sports-disadvantaged college students: A randomised trial. Journal of Health, Population and Nutrition, 43, Artigo 203. DOI: https://doi.org/10.1186/s41043-024-00691-4

Wilmer, M. T., Anderson, K., & Reynolds, M. (2021). Correlates of quality of life in anxiety disorders: Review of recent research. Current Psychiatry Reports, 23(11), 77. DOI: https://doi.org/10.1007/s11920-021-01290-4

Wu, C., et al. (2025). The characteristics of anhedonia in depression: A review from a clinically oriented perspective. Translational Psychiatry, 15(1), 90. DOI: https://doi.org/10.1038/s41398-025-03310-w

Yu DJ, Yu AP, Leung CK, Chin EC, Fong DY, Cheng CP, Yau SY, Siu PM. Comparison of moderate and vigorous walking exercise on reducing depression in middle-aged and older adults: A pilot randomized controlled trial. Eur J Sport Sci. 2023 Jun;23(6):1018-1027.

Yu, D. J., Yu, A. P., Leung, C. K., Chin, E. C., Fong, D. Y., Cheng, C. P., Yau, S. Y., & Siu, P. M. (2023). Comparison of moderate and vigorous walking exercise on reducing depression in middle-aged and older adults: A pilot randomized controlled trial. European Journal of Sport Science, 23(6), 1018–1027. DOI: https://doi.org/10.1080/17461391.2022.2079424

Zhang, Y., & Jiang, X. (2025). The effect of Baduanjin exercise on the physical and mental health of college students: A randomized controlled trial. Medicine, 104(11), Artigo e37104.

Como Citar

Cabral Holanda, A. V. ., Costa Freitas, A. H., Vieira, J. K. C. ., & Junior, S. V. G. (2026). EFEITOS DO EXERCÍCIO FÍSICO SOBRE SINTOMAS DE ANSIEDADE E DEPRESSÃO EM ADULTOS: REVISÃO SISTEMÁTICA E META-ANÁLISESTEMÁTICA E META-ANÁLISE. RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 7(6), e768323. https://doi.org/10.47820/recima21.v7i6.8323