CÁNCER DE PRÓSTATA Y PLANTAS MEDICINALES: UNA ALTERNATIVA TERAPÉUTICA
DOI:
https://doi.org/10.47820/recima21.v4i2.2647Palabras clave:
Cáncer de próstata. Tratamiento. Plantas medicinales.Resumen
El cáncer de próstata se considera un cáncer de edad avanzada, que ocurre en la mayoría a partir de los 65 años, siendo, en la población masculina, la forma más frecuente de cáncer, con alta incidencia y tasa de mortalidad. Debido a que se considera un problema de salud pública, las plantas medicinales, que siempre han estado presentes en la terapia auxiliar de ciertas enfermedades, pueden servir como una herramienta en el tratamiento de esta neoplasia. Así, este estudio tiene como objetivo estudiar las propiedades de las plantas medicinales como alternativa terapéutica en el tratamiento del cáncer de próstata. Se realizó una revisión bibliográfica estudiando la funcionalidad de los bioactivos vegetales como una forma de ayudar en la resolución y mejora del cuadro clínico en cáncer de próstata, investigando en bibliotecas virtuales, como PubMed, con las palabras "Plantas medicinales" O "Cáncer de próstata" O "Próstata Y tratamiento". Se observó que las sustancias estudiadas presentaban una protección relevante contra la metástasis y el crecimiento tumoral, lo que lleva a una buena acción terapéutica. La curcumina se observó inhibiendo la acción del estímulo NFkB y AR, además de la regulación de Bax y Bcl-2, así como la actividad de PSA y TGF-B. Además, se observó que los componentes del ajo también tenían actividad beneficiosa, principalmente Trisulfuro de Dialila, y en igual importancia, Epigalocatequina-3-galato, presente en el Té Verde, que también presentó resultados beneficiosos para el control del crecimiento tumoral. Por lo tanto, la fitoterapia.
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ASADI-SAMANI, Majid et al. A Systematic Review of Iran’s Medicinal Plants With Anticancer Effects. Journal Of Evidence-Based Complementary & Alternative Medicine, v. 21, n. 2, p. 143-153, 21 ago. 2015.
BATIHA, Gaber El-Saber et al. Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): a review. Nutrients, v. 12, n. 3, p. 872, 24 mar. 2020.
BRASIL. Ministerio da Saúde. Abordagens Basicas para o Controle do Cancer, Instituto Nacional do Câncer, ago. 2011.
CHANDRA-KUNTAL, Kumar; SINGH, Shivendra V.. Diallyl Trisulfide Inhibits Activation of Signal Transducer and Activator of Transcription 3 in Prostate Cancer Cells in Culture and In vivo. Cancer Prevention Research, v. 3, n. 11, p. 1473-1483, 19 out. 2010.
CHUNG, L.y. et al. Induction of apoptosis by green tea catechins in human prostate cancer DU145 cells. Life Sciences, v. 68, n. 10, p. 1207-1214, jan. 2001.
CHUU, Chih-Pin et al. Suppression of androgen receptor signaling and prostate specific antigen expression by (−)-epigallocatechin-3-gallate in different progression stages of LNCaP prostate cancer cells. Cancer Letters, v. 275, n. 1, p. 86-92, mar. 2009.
DEEB, Dorrah et al. Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-kappaB through suppression of IkappaBalpha phosphorylation. Molecular Cancer Therapeutics, v. 3(7), p. 803-812, jul. 2004.
DORAI, Thambi et al. Curcumin Inhibits Prostate Cancer Bone Metastasis by Up-Regulating Bone Morphogenic Protein-7 in Vivo. Journal Of Cancer Therapy, v. 05, n. 04, p. 369-386, 2014.
FEITOZA, Lais et al. Plantas Medicinais e seus Compostos com Potencial Terapêutico no Tratamento do Câncer: Revisão Integrativa. Revista Brasileira de Cancerologia, v. 67, n. 1, p. 2-8, 11 jan. 2021.
FERLAY, J et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. International Journal Of Cancer, v. 114(8), p. 1941-1953, 15 abr. 2019.
GUO, Yuming et al. Green tea and the risk of prostate cancer: a systematic review and meta-analysis. Medicine, v. 96:13, mar. 2017.
HENNING, Susanne M. et al. Randomized clinical trial of brewed green and black tea in men with prostate cancer prior to prostatectomy. The Prostate, v. 75, n. 5, p. 550-559, 24 dez. 2014.
HERMAN-ANTOSIEWICZ, Anna et al. Diallyl Trisulfide-Induced G2/M Phase Cell Cycle Arrest in DU145 Cells Is Associated with Delayed Nuclear Translocation of Cyclin-Dependent Kinase 1. Pharmaceutical Research, v. 27, n. 6, p. 1072-1079, 9 fev. 2010.
HEWLINGS, Susan; KALMAN, Douglas. Curcumin: a review of its effects on human health. Foods, v. 6, n. 10, p. 92, 22 out. 2017.
HSING, A. W.. Allium Vegetables and Risk of Prostate Cancer: a population-based study. Cancerspectrum Knowledge Environment, v. 94, n. 21, p. 1648-1651, 6 nov. 2002.
HUANG, Dong-Ming et al. Modulation of anti-adhesion molecule MUC-1 is associated with arctiin-induced growth inhibition in PC-3 cells. The Prostate, v. 59, n. 3, p. 260-267, 15 maio 2004.
INCA. Câncer de Próstata. Instituto Nacional do Câncer, 2022. Disponível em: https://www.inca.gov.br/assuntos/cancer-de-prostata.
JOHNSON, J.J.; BAILEY, H.H.; MUKHTAR, H.. Green tea polyphenols for prostate cancer chemoprevention: a translational perspective. Phytomedicine, v. 17, n. 1, p. 3-13, jan. 2010.
JORDAN, Brian C. et al. Molecular mechanisms of curcumin and its semisynthetic analogues in prostate cancer prevention and treatment. Life Sciences, v. 152, p. 135-144, maio 2016.
KIM, Su-Hyeong; BOMMAREDDY, Ajay; SINGH, Shivendra V.. Garlic Constituent Diallyl Trisulfide Suppresses X-linked Inhibitor of Apoptosis Protein in Prostate Cancer Cells in Culture and In Vivo. Cancer Prevention Research, v. 4, n. 6, p. 897-906, 16 mar. 2011.
KUMAR, Nagi B. et al. Green tea extract for prevention of prostate cancer progression in patients on active surveillance. Oncotarget, v. 9, n. 102, p. 37798-37806, 28 dez. 2018.
MANCINI, Natalia. Uso de plantas medicinais para o tratamento do cancer. Revista Abrale Online, 8 jun. 2021.
NEVEDOMSKAYA, Ekaterina et al. Recent Advances in Prostate Cancer Treatment and Drug Discovery. International Journal Of Molecular Sciences, v. 19(5), p. 1359, 4 maio 2018.
PETROPOULOS, Spyridon et al. Nutritional Value, Chemical Characterization and Bulb Morphology of Greek Garlic Landraces. Molecules, v. 23, n. 2, p. 319, 2 fev. 2018.
SCHULZ, W.A.. Molecular biology of prostate cancer. Molecular Human Reproduction, v. 9, n. 8, p. 437-448, 1 ago. 2003.
SHANKAR, Sharmila et al. Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis. Molecular Cancer, v. 7:16, 29 jan. 2008.
SHANMUGAM, Muthu et al. The Multifaceted Role of Curcumin in Cancer Prevention and Treatment. Molecules, v. 20, n. 2, p. 2728-2769, 5 fev. 2015.
TEITEN, Marie-Hélène et al. Chemopreventive potential of curcumin in prostate cancer. Genes & Nutrition, v. 5, n. 1, p. 61-74, 6 out. 2009.
TERMINI, Deborah et al. Curcumin against Prostate Cancer: current evidence. Biomolecules, v. 10, n. 11, p. 1536, 10 nov. 2020.
TSUI, K.-H. et al. Curcumin Blocks the Activation of Androgen and Interlukin-6 on Prostate-Specific Antigen Expression in Human Prostatic Carcinoma Cells. Journal Of Andrology, v. 29, n. 6, p. 661-668, 31 jul. 2008.
VANINI, M et al. Uso de plantas medicinales por pacientes oncologicos y familiars en un centro de radioterapia. Enfermería Global, n. 21, p. 2, jan. 2011.
WEI, Xingchuan et al. Effects of cyclohexanone analogues of curcumin on growth, apoptosis and NF-κB activity in PC-3 human prostate cancer cells. Oncology Letters, v. 4, n. 2, p. 279-284, 10 maio 2012.
WEINLICH, G. et al. Metallothionein-overexpression as a prognostic factor for progression and survival in melanoma. A prospective study on 520 patients. British Journal Of Dermatology, v. 149, n. 3, p. 535-541, set. 2003.
XIAO, Dong et al. Diallyl Trisulfide Suppresses Growth of PC-3 Human Prostate Cancer Xenograft In vivo in Association with Bax and Bak Induction. Clinical Cancer Research, v. 12, n. 22, p. 6836-6843, 15 nov. 2006.
XIAO, Dong; SINGH, Shivendra V.. Diallyl trisulfide, a constituent of processed garlic, inactivates Akt to trigger mitochondrial translocation of BAD and caspase-mediated apoptosis in human prostate cancer cells. Carcinogenesis, v. 27, n. 3, p. 533-540, 16 set. 2005.
YANG, Chung S. et al. Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nature Reviews Cancer, v. 9, n. 6, p. 429-439, 14 maio 2009.
YANG, Jiayi et al. Effect of curcumin on Bcl-2 and Bax expression in nude mice prostate cancer. International Journal Of Clinical And Experimental Pathology, v. 8(8), p. 9272-9278, ago. 2015.
ZHOU, Dai-Ying et al. Pyridine analogues of curcumin exhibit high activity for inhibiting CWR-22Rv1 human prostate cancer cell growth and androgen receptor activation. Oncology Letters, v. 11, n. 6, p. 4160-4166, 6 maio 2016.
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