CARDIOVASCULAR BENEFITS OF MODERATE RED WINE CONSUMPTION
Abstract
Introduction: red wine consumption has been studied since 1981, when the French paradox of fewer cardiovascular diseases despite higher alcohol consumption was discovered. Given the above, this study aims to clarify the benefits of red wine consumption on cardiovascular health. Methodology: this is an integrative literature review, in which the terms "red wine", "cardiovascular health" and "benefits" were searched, combined by Boolean operators. Articles published between January 2010 and January 2022 were delimited. Results and discussion: individuals with comorbidities, such as hypercholesterolemic and diabetic individuals benefited from moderate red wine consumption through increased body antioxidant capacity and cholesterol regulation. The phenolic compounds in wine may be able to modulate leukocyte adhesion, while ethanol and polyphenols may modulate inflammatory mediators. Further, the association between wine consumption and physical exercise was shown to be effective in controlling blood pressure and cholesterol levels. Final considerations: Therefore, this study concludes that moderate intake of red wine associated with exercise and a balanced diet has cardiovascular benefits, even in patients at risk. The phenolic compounds and ethanol, present in wine, serve as modulators at the molecular level.
Author Biographies
Curso de Medicina, Unicesumar, Maringá, Paraná, Brasil
Curso de Medicina, Unicesumar, Maringá, Paraná, Brasil
Curso de Medicina, Universidade José do Rosário Vellano, Alfenas, Minas Gerais, Brasil
Curso de Medicina, Universidade José do Rosário Vellano, Alfenas, Minas Gerais, Brasil
Estudante do 7° período de medicina na Faculdade Atenas - Campus Passos. Membro fundador da Liga Acadêmica de Neurologia e Neurocirurgia da Faculdade Atenas. Membro da Liga Acadêmica de Urgência e Emergência da Faculdade Atenas. Embaixador do programa BRAINterns, do Lenox Hill Hospital, NY - EUA. Membro estudante da Academia Europeia de Neurologia e da Sociedade Brasileira de Clínica Médica.
References
Haseeb S, Alexander B, Baranchuk A. Wine and Cardiovascular Health: A Comprehensive Review. Circulation. 2017 Oct 10;136(15):1434-1448. PMID: 28993373 DOI: https://doi.org/10.1161/CIRCULATIONAHA.117.030387
Snopek L, Mlcek J, Sochorova L, Baron M, Hlavacova I, Jurikova T, Kizek R, Sedlackova E, Sochor J. Contribution of Red Wine Consumption to Human Health Protection. Molecules. 2018 Jul 11;23(7):1684. PMID: 29997312; PMCID: PMC6099584 DOI: https://doi.org/10.3390/molecules23071684
Stephan LS, Almeida ED, Markoski MM, Garavaglia J, Marcadenti A. Red Wine, Resveratrol and Atrial Fibrillation. Nutrients. 2017 Oct 30;9(11):1190. PMID: 29084143; PMCID: PMC5707662 DOI: https://doi.org/10.3390/nu9111190
Fernandes I, Pérez-Gregorio R, Soares S, Mateus N, de Freitas V. Wine Flavonoids in Health and Disease Prevention. Molecules. 2017 Feb 14;22(2):292. PMID: 28216567; PMCID: PMC6155685 DOI: https://doi.org/10.3390/molecules22020292
Teissedre P.L., Stockley C., Boban M., Ruf J.C., Alba M.O., Gambert P., Flesh M. The effects of wine consumption on cardiovascular disease and associated risk factors: A narrative review. OENO ONE. 2018;52:67–79 DOI: https://doi.org/10.20870/oeno-one.2018.52.1.2129
Naame SA, Li D, Huang R. Effects of moderate red wine on cardiovascular risk factors in diabetics: a systematic review and meta-analysis of randomized controlled trials. Toxicol Res (Camb). 2019 Nov 12;8(6):979-987. PMID: 32922738; PMCID: PMC7477824 DOI: https://doi.org/10.1039/c9tx00227h
Del Pino-García R., González-SanJosé M.L., Rivero-Pérez M.D., García-Lomillo J., Muñiz P. The effects of heat treatment on the phenolic composition and antioxidant capacity of red wine pomace seasonings. Food Chem. 2017;221:1723–1732 DOI: https://doi.org/10.1016/j.foodchem.2016.10.113
Ercole FF, Melo LS, Alcoforado CLGC. Integrative review versus systematic review. Reme Rev Min Enferm [Serial on the Internet]. 2014 [cited 2018 May 15];18(1):9-12. Available from: http://www.gnresearch.org/doi/10.5935/1415-2762.20140001
Apostolidou C, Adamopoulos K, Lymperaki E, Iliadis S, Papapreponis P, Kourtidou-Papadeli C. Cardiovascular risk and benefits from antioxidant dietary intervention with red wine in asymptomatic hypercholesterolemics. Clin Nutr ESPEN. 2015;10(6):e224-e233 DOI: https://doi.org/10.1016/J.CLNESP.2015.08.001
Gepner Y, Golan R, Harman-Boehm I, et al. Effects of initiating moderate alcohol intake on cardiometabolic risk in adults with type 2 diabetes: A 2-year randomized, controlled trial. Ann Intern Med. 2015;163(8):569-579 DOI: https://doi.org/10.7326/M14-1650
Chiva-Blanch G, Urpi-Sarda M, Llorach R, et al. Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines related to atherosclerosis: A randomized clinical trial. Am J Clin Nutr. 2012;95(2):326-334 DOI: https://doi.org/10.3945/ajcn.111.022889
Vázquez-Fresno R, Llorach R, Alcaro F, et al. 1H-NMR-based metabolomic analysis of the effect of moderate wine consumption on subjects with cardiovascular risk factors. Electrophoresis. 2012;33(15):2345-2354 DOI: https://doi.org/10.1002/elps.201100646
Filho PRS, Castro I, Stahlschmidt A. Effect of red wine associated with physical exercise in the cardiovascular system of spontaneously hipertensive rats. Arq Bras Cardiol. 2011;96(4):277-282 DOI: https://doi.org/10.1590/S0066-782X2011005000020
License
Copyright (c) 2022 RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218
This work is licensed under a Creative Commons Attribution 4.0 International License.
Os direitos autorais dos artigos/resenhas/TCCs publicados pertecem à revista RECIMA21, e seguem o padrão Creative Commons (CC BY 4.0), permitindo a cópia ou reprodução, desde que cite a fonte e respeite os direitos dos autores e contenham menção aos mesmos nos créditos. Toda e qualquer obra publicada na revista, seu conteúdo é de responsabilidade dos autores, cabendo a RECIMA21 apenas ser o veículo de divulgação, seguindo os padrões nacionais e internacionais de publicação.