NUTRITIONAL STATUS OF SELENIUM IN BREAST CANCER: A SYSTEMATIC REVIEW AND META-ANALYSIS
Abstract
Selenium is an essential micronutrient, with antioxidant action and role in cellular defense, and the selenium nutritional status in women with breast cancer has aroused increasing scientific interest. This systematic review and meta-analysis evaluated the nutritional status of selenium in women with and without breast cancer. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The study sought to answer the guiding question: “Does the nutritional status related to selenium in women with breast cancer present changes compared to that of women without breast cancer?”. The search took place in PubMed, Web of Science and Embase. Studies that evaluated the nutritional status of selenium in women with breast cancer, compared to women without the disease, were included. Twenty-six articles were identified as eligible. Dietary selenium levels were reduced in women with breast cancer compared to the control group. Reduced concentrations of the mineral in serum, hair and nails were found in women with breast cancer. There were divergent results regarding the activity of the glutathione peroxidase enzyme. The results show compromised nutritional status related to selenium in women with breast cancer; however, the results of the studies are still controversial. This can be justified by the complex metabolism of the nutrient, which may be influenced by physiological changes associated with breast cancer.
Author Biographies
Msc, Postgraduate Program in Food and Nutrition, Federal University of Piaui, Campus Minister Petrônio Portela, Ininga, Teresina, Piaui, Brazil.
Msc, Postgraduate Program in Food and Nutrition, Federal University of Piaui, Campus Minister Petrônio Portela, Ininga, Teresina, Piaui, Brazil.
PhD Student, Postgraduate Program in Nutrition in Public Health, University of São Paulo, São Paulo, Brazil.
PhD Student, Postgraduate Program in Food and Nutrition, Federal University of Piaui, Campus Minister Petrônio Portela, Ininga, Teresina, Piaui, Brazil.
PhD Student, Postgraduate Program in Food and Nutrition, Federal University of Piaui, Campus Minister Petrônio Portela, Ininga, Teresina, Piaui, Brazil.
PhD Student, Postgraduate Program in Food and Nutrition, Federal University of Piaui, Campus Minister Petrônio Portela, Ininga, Teresina, Piaui, Brazil.
Msc Student, Postgraduate Program in Food and Nutrition, Federal University of Piaui, Campus Minister Petrônio Portela, Ininga, Teresina, Piaui, Brazil.
Msc Student, Postgraduate Program in Food and Nutrition, Federal University of Piaui, Campus Minister Petrônio Portela, Ininga, Teresina, Piaui, Brazil.
PhD, Department of Nutrition, Federal University of Piaui, Campus Minister Petrônio Portela, Ininga, Teresina, Piaui, Brazil.
PhD, Department of Nutrition, Federal University of Piaui, Campus Minister Petrônio Portela, Ininga, Teresina, Piaui, Brazil.
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