ESTADO NUTRICIONAL DEL SELENIO EN EL CÁNCER DE MAMA: UNA REVISIÓN SISTEMÁTICA Y UN METANÁLISIS
Resumen
El selenio es un micronutriente esencial con acción antioxidante y función en la defensa celular. El estado nutricional del selenio en mujeres con cáncer de mama ha despertado un creciente interés científico. Esta revisión sistemática y metaanálisis evaluó el estado nutricional de selenio de mujeres con cáncer de mama en comparación con mujeres sin la enfermedad. La revisión se realizó de acuerdo con las directrices PRISMA (Ítems de Informe Preferidos para Revisiones Sistemáticas y Metaanálisis). El estudio buscó responder a la siguiente pregunta clave: "¿Está alterado el estado nutricional de selenio de las mujeres con cáncer de mama en comparación con las mujeres sin la enfermedad?". La búsqueda se realizó en las bases de datos PubMed, Web of Science y Embase. Se incluyeron estudios que evaluaron el estado nutricional de selenio de mujeres con cáncer de mama en comparación con mujeres sin la enfermedad. Se identificaron veintiséis artículos como elegibles. Los niveles de selenio en la dieta se redujeron en mujeres con cáncer de mama en comparación con el grupo control. Se encontraron concentraciones reducidas del mineral en suero, cabello y uñas en mujeres con cáncer de mama. Se obtuvieron resultados divergentes respecto a la actividad de la enzima glutatión peroxidasa. Los resultados muestran un estado nutricional comprometido relacionado con el selenio en mujeres con cáncer de mama; sin embargo, los resultados de los estudios aún son controvertidos. Esto puede justificarse por el complejo metabolismo del nutriente, que puede verse influido por cambios fisiológicos asociados con el cáncer de mama.
Biografía del autor/a
Msc, Programa de Postgrado en Alimentación y Nutrición, Universidad Federal de Piaui, Campus Minister Petrônio Portela, Ininga, Teresina, Piaui, Brasil.
Msc, Programa de Postgrado en Alimentación y Nutrición, Universidad Federal de Piaui, Campus Minister Petrônio Portela, Ininga, Teresina, Piaui, Brasil.
Estudiante de Doctorado, Programa de Postgrado en Nutrición en Salud Pública, Universidad de São Paulo, São Paulo, Brasil.
Estudiante de Doctorado, Programa de Postgrado en Alimentación y Nutrición, Universidad Federal de Piaui, Campus Minister Petrônio Portela, Ininga, Teresina, Piaui, Brasil.
Estudiante de Doctorado, Programa de Postgrado en Alimentación y Nutrición, Universidad Federal de Piaui, Campus Minister Petrônio Portela, Ininga, Teresina, Piaui, Brasil.
Estudiante de Doctorado, Programa de Postgrado en Alimentación y Nutrición, Universidad Federal de Piaui, Campus Minister Petrônio Portela, Ininga, Teresina, Piaui, Brasil.
Estudiante de Maestría, Programa de Postgrado en Alimentación y Nutrición, Universidad Federal de Piaui, Campus Minister Petrônio Portela, Ininga, Teresina, Piaui, Brasil.
Estudiante de Maestría, Programa de Postgrado en Alimentación y Nutrición, Universidad Federal de Piaui, Campus Minister Petrônio Portela, Ininga, Teresina, Piaui, Brasil.
Doctor, Departamento de Nutrición, Universidad Federal de Piauí, Campus Ministro Petrônio Portela, Ininga, Teresina, Piauí, Brasil.
Doctor, Departamento de Nutrición, Universidad Federal de Piaui, Campus Minister Petrônio Portela, Ininga, Teresina, Piaui, Brasil.
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