TERAPIA CON FAGOS: UN ENFOQUE INNOVADOR PARA TRATAR LAS INFECCIONES POR BACTERIAS RESISTENTES
Resumen
Entre los problemas a los que se enfrentan las enfermedades infecciosas hoy en día, la resistencia bacteriana a los antibióticos es una amenaza significativa para la salud pública, especialmente en lo que se refiere al tratamiento de las infecciones. Así, en la era de la resistencia a los antibióticos, los bacteriófagos se han convertido en un potencial producto terapéutico contra las infecciones. Los bacteriófagos son virus que infectan bacterias con gran especificidad y que también pueden diseñarse, mediante ingeniería genética, para exterminar cepas resistentes a los antibióticos. En Brasil, al menos un millón de personas al año se ven afectadas por infecciones resistentes, siendo las bacterias más preocupantes Klebsiella pneumoniae, Escherichia coli y Acinetobacter baumanii. La terapia con fagos puede dividirse en dos enfoques principales: personalizado y no personalizado, siendo el primero el que obtiene mejores resultados. Los fagos demostraron ser bien tolerados y seguros, independientemente de la vía utilizada. Sin embargo, los ensayos clínicos aún carecen de una sistematización completa de la metodología, y es crucial promover e invertir en ensayos clínicos bien estructurados para garantizar mejores resultados para los pacientes.
Biografía del autor/a
Discente do curso de Bacharelado em Biomedicina pela Faculdade UNITERP-FACTERP, São José do Rio Preto, São Paulo.
Mestrando em Microbiologia pela Universidade Estadual Paulista (UNESP), MBA em Gestão de Saúde pelo Centro Universitário São Camilo. Docente do curso de Biomedicina da Faculdade UNITERP-FACTERP, São Josè do Rio Preto, São Paulo.
Mestre em Microbiologia pela Universidade Estadual Paulista (UNESP). Especialista em Saúde Pública. Coordenadora e docente do curso de Biomedicina da Faculdade UNITERP-FACTERP, São José do Rio Preto, São Paulo.
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