TERAPIA FÁGICA: UMA ABORDAGEM INOVADORA NO TRATAMENTO DE INFECÇÕES POR BACTÉRIAS RESISTENTES
Resumo
Dentre as problemáticas da infectologia, na atualidade, a resistência bacteriana a antibióticos se apresenta como uma ameaça expressiva à saúde populacional, principalmente no quesito de tratamento de infecções. Assim, em uma era de resistência antibiótica, os bacteriófagos se tornam um produto terapêutico em potencial contra infecções. Os bacteriófagos são vírus que infectam bactérias com alta especificidade e também podem ser projetados utilizando engenharia genética para exterminar cepas resistentes a antibióticos. No mínimo 1 milhão de pessoas por ano são acometidas por infecções resistentes no Brasil, as bactérias mais preocupantes são Klebsiella pneumoniae, Escherichia coli e Acinetobacter baumanii. A terapia com fagos pode ser dividida em duas principais abordagens: a personalizada e a não personalizada, sendo que a primeira possui melhores resultados. Os fagos demonstraram ser bem tolerados e seguros, independentemente da via utilizada. Contudo, os ensaios clínicos ainda carecem de sistematização completa da metodologia, sendo crucial promover e investir em ensaios clínicos bem estruturados para garantir melhores resultados aos pacientes.
Biografia do Autor
Discente do curso de Bacharelado em Biomedicina pela Faculdade UNITERP-FACTERP, São José do Rio Preto, São Paulo.
Mestrando em Microbiologia pela Universidade Estadual Paulista (UNESP), MBA em Gestão de Saúde pelo Centro Universitário São Camilo. Docente do curso de Biomedicina da Faculdade UNITERP-FACTERP, São Josè do Rio Preto, São Paulo.
Mestre em Microbiologia pela Universidade Estadual Paulista (UNESP). Especialista em Saúde Pública. Coordenadora e docente do curso de Biomedicina da Faculdade UNITERP-FACTERP, São José do Rio Preto, São Paulo.
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