ÁCIDO OKADAICO EM CÉLULAS EUCARIÓTICAS: MECANISMOS, IMPACTOS NA SAÚDE HUMANA E DESAFIOS PARA O MONITORAMENTO
Resumo
As florações de algas nocivas (FANs) caracterizam-se pela proliferação de microalgas capazes de gerar graves impactos aos ecossistemas aquáticos e à saúde humana, especialmente pelo consumo de organismos filtradores contaminados. O ácido ocadaico (AO) é uma das principais toxinas marinhas associadas a esses eventos, sendo o agente causador da Intoxicação Diarreica por Moluscos (DSP). Atualmente, há crescentes evidências de seus efeitos tóxicos em diversos modelos biológicos. Este artigo de revisão analisa a literatura publicada entre 2019 e 2025 para elucidar as evidências mais recentes sobre a toxicidade do AO. O estudo foca em seus mecanismos de ação, manifestações clínicas, efeitos crônicos e ecotoxicológicos, além de avaliar os atuais métodos de detecção e estratégias de gestão de risco. Por fim, a revisão destaca lacunas de conhecimento e recomenda prioridades para a pesquisa e vigilância, visando a mitigação dos riscos à saúde pública e à aquicultura.
Biografia do Autor
Mestrando em Engenharia Ambiental pelo Instituto Federal Fluminense (IFF).
Doutorando em Modelagem e Tecnologia para o Meio Ambiente Aplicada aos Recursos Hídricos no IFF. Professor no Município de Araruama.
Doutor em Fisiopatologia Clínica Experimental pela Universidade do Estado do Rio de Janeiro (UERJ). Professor no Programa de Pós-Graduação em Biologia Vegetal da UERJ.
Doutor em Fisiopatologia Clínica Experimental pela Universidade do Estado do Rio de Janeiro (UERJ). Professor no Programa de Pós-Graduação em Biologia Vegetal da UERJ.
Doutor em Direitos Humanos pela Universidade de Coimbra. Professor no Programa de Pós-Graduação em Engenharia Ambiental do IFF.
Doutor em Ciências Biológicas (Biofísica) pela UERJ. Professor de Biologia no IFF.
Doutor em Ciências Biológicas (Biociências Nucleares) pela UERJ. Professor no Programa de Pós-Graduação em Biologia Vegetal da UERJ.
Doutor em Ciências Biológicas (Biociências Nucleares) pela UERJ. Professor no Programa de Pós-Graduação em Engenharia Ambiental do IFF.
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