SUPLEMENTAÇÃO DE SELÊNIO EM ZEBRAFISH (Danio rerio): UMA REVISÃO INTEGRATIVA
DOI:
https://doi.org/10.47820/recima21.v6i12.7001Palavras-chave:
Genética, Selênio, ZebrafishResumo
O selênio (Se) é essencial para o funcionamento celular de todos os organismos e desempenha papel protetor dos efeitos nocivos causados pelos radicais livres. O Danio rerio (zebrafish) é um modelo animal muito utilizado em muitas pesquisas, possui diversas vantagens como: semelhança fisiológica com mamíferos, facilidade de manipulação genética, larvas opticamente claras, além disso, são animais altamente férteis, de baixo custo e manutenção devido ao seu tamanho. O objetivo deste trabalho é realizar uma revisão integrativa da literatura disponível sobre o papel e a suplementação de Se em Danio rerio. A revisão foi realizada nas bases de dados Pubmed, BVS, Scopus, Web of Science e Periódico da Capes, realizando uma busca avançada por meio das palavras chaves selecionadas. Mais de 700 artigos foram identificados. Os artigos incluídos foram publicados em inglês, português ou espanhol, a partir do ano de 2005, também foram considerados artigos que avaliaram o papel do Se em zebrafish, considerando o efeito à exposição, genética, comportamento e toxicidade. Selecionou-se 37 artigos experimentais e originais que se adequavam aos objetivos do trabalho. O efeito do Se no zebrafish depende muito da forma e da concentração de Se a que o animal é exposto. Os trabalhos apontam o Se com possível efeito redutor no risco de cânceres, e avaliam o seu potencial na prevenção à toxicidade ao acúmulo de metil mercúrio. Todavia, em doses altas, o selênio, além de causar toxicidade, também altera o comportamento do zebrafish, interferindo no processo de memória, natação e reconhecimento espacial.
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