A DOENÇA DE CROHN EM DECORRÊNCIA DA DESREGULAÇÃO DO SISTEMA IMUNOLÓGICO
DOI:
https://doi.org/10.47820/recima21.v3i8.1844Palavras-chave:
''sistema imune'', ''doença de crohn''Resumo
Introdução: A doença de Crohn (DC) se trata de uma doença inflamatória intestinal incurável em que ocorre a inflamação e ulceração da mucosa no trato gastrointestinal. Os linfócitos do sistema imune, controlam o processo inflamatório causando o aumento excessivo das citocinas pró-inflamatórias. Objetivo: Analisar a influência do sistema imunológico na origem e desenvolvimento da DC. Materiais e Métodos: Foi realizada uma revisão integrativa de literatura, com o objetivo de correlacionar o sistema imunológico com a DC. Para a análise de dados foram incluídos estudo clínico, ensaio clínico, estudo comparativo, metanálise, estudo multicêntrico, estudo observacional e ensaio controlado randomizado. Para esse estudo foram utilizados artigos da base de dados Pubmed, publicados entre os anos de 2018 até 2022. Os descritores escolhidos foram "crohn 's disease” e “immune system”. Foram excluídos livros e documentos, análises e revisões sistemáticas. Após critérios de inclusão e exclusão foram selecionados 28 artigos. Resultados: As citocinas e quimiocinas liberadas a partir do aumento de neutrófilos aumentarão a gravidade da inflamação. Nesse processo serão expressos interleucina-1, interleucina-6 e fator de necrose tumoral-α. Conclusão: O sistema imune possui forte relação com a progressão da DC a partir de um desequilíbrio da produção de células de defesa, desencadeando lesões imunológicas e infiltrações proeminentes dessas células.
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