AN OVERVIEW OF THE RESISTANCE MECHANISMS OF CANDIDA ALBICANS AND THE TREATMENT OF RECURRENT CANDIDIASIS
DOI:
https://doi.org/10.47820/recima21.v4i3.2867Keywords:
recurrent vulvovaginal candidiasis, treatment, candidiasis, vaginosis.Abstract
Recurrent candidiasis, or recurrent vulvovaginal candidiasis (RVC), is a condition that affects thousands of women worldwide every year. The most characteristic symptoms are known to be itching, vulvar pain, dysuria, and leukorrhea, and recurrence is determined when at least four different episodes of vulvovaginal candidiasis occur within a 12-month period. Several factors may influence its recurrence, including genetic, biological, or behavioral causes. Although CVR is a very common disease in the population, it is also known for its deleterious complications if not treated properly, including infertility, premature birth, miscarriage, and other infectious diseases. The classic recommended treatment for CVR is the use of antifungals, however, an increase in resistance to these drugs has been observed in recent years. In response, new therapeutic approaches have been tested, with vaccines against Candida ssp., drugs based on biofilm eradication, nanotechnology and peptides, lactobacilli and immunotherapy, as possible alternatives to exclusive reliance on antifungals. This study aims to analyze the therapeutic methods available for RVC through a review of existing literature, with the purpose of developing an overview of the current management and news about the treatment of recurrent vulvovaginal candidiasis, to elucidate the medical practice before this frequent complaint in medical offices, both clinical and gynecological.
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