EFFECT OF EXTRACTS FROM GUINEA LEAVES (PETIVERIA ALLIACEA L) ON BIOCHEMICAL AND HISTOLOGICAL PARAMETERS IN DIABETIC RATS

Abstract

Diabetes Mellitus (DM) is an endocrine and metabolic disorder increasingly common in the world population, lacking new therapeutic alternatives, and vegetables are a viable alternative in the search for new phytotherapics and bioactives with action to control DM. Due to the hypoglycemic activity of some bioactives of Guinea leaves (Petiveria alliacea), in addition to this being a plant widely spread throughout Brazil, easy to grow and access, the present study evaluated the influence of extracts of Guinea leaves on biochemical and morphological parameters. of Wistar rats with alloxan-induced DM. The animals were divided into three experimental groups: rats without DM (n = 10), rats with DM (n = 10) and rats with DM treated with P. alliacea leaf extract (200mg/Kg/day) (n = 10). Biochemical parameters: glucose, hepatic (TGP and TGO), renal (creatinine and urea) and lipid (total cholesterol and triglycerides) profile, as well as organ histology were evaluated. P. alliacea leaf extract, at a dose of 200mg/kg/day, was not able to prevent increases in glucose, TGP, TGO, creatinine, urea, total cholesterol, and triglycerides in animals with DM compared to the group untreated DM. There were no significant histopathological changes in the liver, kidneys, heart, and salivary glands. We emphasize the need for new studies to evaluate such preliminary findings, aiming to clarify the effects observed here.