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ACALABRUTINIB IN THE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA

Authors

Carollayne Mendonça Rocha
Breno Camargo Ribeiro https://orcid.org/0009-0003-6991-0416
Gustavo Dourado Franco https://orcid.org/0009-0001-1435-1608
Hugo Abboud https://orcid.org/0000-0002-3741-6806
Isabella Sales dos Santos https://orcid.org/0000-0002-2361-9573
João Pedro Guedes Pinto https://orcid.org/0009-0006-3390-1755
Julia de Oliveira Lima https://orcid.org/0009-0004-9851-3126
Murilo Monroe Mota https://orcid.org/0009-0004-8639-6495
Vinicius do Prado https://orcid.org/0009-0007-0878-2923
Eric Azara de Oliveira https://orcid.org/0000-0002-3663-1627

DOI:

https://doi.org/10.47820/recima21.v4i6.3311

Keywords:

Chronic lymphocytic leukemia

Abstract

Introduction: Chronic lymphocytic leukemia is the most common adult leukemia. It is characterized by clonal expansion of mature CD5+ B cells into blood, bone marrow, and lymphoid tissues. Objectives: To evaluate the efficacy and adverse events of the use of acalabrutinib in the treatment of chronic lymphocytic leukemia. Materials and methods: This is an integrative review, in which the guiding question was “Is acalabrutinib effective in the treatment of chronic lymphocytic leukemia?”. The search for articles was carried out in the main databases (PubMed and Scielo) using the terms “acalabrutinib” and “chronic lymphocytic leukemia”, combined using Boolean operators. Results and Discussion: Compared to ibrutinib, acalabrutinib is highly selective and characterized by a lack of inhibition towards other kinases. Overall survival comparisons favored acalabrutinib alone and in combination with obinutuzumab over all comparators. Acalabrutinib monotherapy was also associated with statistically improved progression-free survival over obinutuzumab-chlorambucil. Conclusion: Acalabrutinib is an effective and safe treatment of chronic lymphocytic leukemia. Acalabrutinib plus obinutuzumab or acalabrutinib monotherapy were associated with improved efficacy over standard immunochemotherapy.

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Author Biographies

Carollayne Mendonça Rocha

Universidade José do Rosário Vellano - UNIFENAS.

Breno Camargo Ribeiro

Universidade Professor Edson Antônio Velano - UNIFENAS.

Gustavo Dourado Franco

Universidade Professor Edson Antônio Velano - UNIFENAS.

Hugo Abboud

Universidade Professor Edson Antônio Velano - UNIFENAS.

Isabella Sales dos Santos

Universidade Professor Edson Antônio Velano - UNIFENAS.

João Pedro Guedes Pinto

Universidade Professor Edson Antônio Velano - UNIFENAS.

Julia de Oliveira Lima

Universidade Professor Edson Antônio Velano - UNIFENAS.

Murilo Monroe Mota

Universidade Professor Edson Antônio Velano - UNIFENAS.

Vinicius do Prado

Universidade Professor Edson Antônio Velano - UNIFENAS.

Eric Azara de Oliveira

Universidade Professor Edson Antônio Velano - UNIFENAS.

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Published

09/06/2023

How to Cite

Mendonça Rocha, C., Camargo Ribeiro, B., Dourado Franco, G., Abboud, H., Sales dos Santos, I., Guedes Pinto, J. P., … Azara de Oliveira, E. (2023). ACALABRUTINIB IN THE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA. RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 4(6), e463311. https://doi.org/10.47820/recima21.v4i6.3311

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