EFFECTS OF HYDROALCOHOLIC EXTRACT OF PETROSELINUM CRISPUM ON CUTANEOUS WOUND HEALING IN RATS

Abstract

The empirical use of Petroselinum crispum in wound healing is part of traditional practices in the interior of Brazil. However, its effects had not been scientifically established. Objective: To evaluate the healing effect of parsley extract on rat wounds and compare it to treatment with honey and the combination of parsley and honey. Methodology: 60 rats were subjected to anesthesia, manual depilation, antiseptic procedures, and a 15 mm diameter surgical incision on the dorsal region. The animals were randomly divided into four groups: control (CT, n = 15), with the application of 1 gram of non-ionic cream; parsley group (S, n = 15), with the application of 1 gram of 10% parsley extract cream; parsley and honey group (SM, n = 15), with the application of 1 gram of 10% parsley extract cream and 10% honey extract; honey group (M, n = 15), with the application of 1 gram of 10% honey. Results: The groups M, S, and SM showed a lower number of mononuclear cells, less intense inflammatory signs, and earlier wound edge retraction compared to the CT group. The amount of fibroblasts at the beginning of the evaluation was higher in the M, S, and SM groups compared to the CT group, with earlier decline. Conclusion: Topical use of parsley extract proved to be effective in the tissue repair of rat wounds.