NEUROBIOLOGICAL FACTORS INVOLVED IN MIGRAINE GENESIS
DOI:
https://doi.org/10.47820/recima21.v4i12.4089Keywords:
Genetic factors; Neurotransmitters; Brain plasticity.Abstract
Introduction: Migraine, one of the most prevalent and debilitating neurological conditions worldwide, has been the subject of intensive investigations aimed at understanding the complex neurobiological factors that contribute to its genesis. Objective: To investigate the neurobiological mechanisms of migraine and possible therapeutic approaches. Methodology: We performed a search in renowned scientific databases, including PubMed, Scopus and Web of Science, selecting studies published between 2013 and 2023 that addressed the neurobiological factors of migraine. Results and Discussion: We identified genetic influence, with variants such as MTHFR increasing the risk of migraine. Glutamatergic neurotransmission and central sensitization play crucial roles in generating pain. Activation of the trigemino-vascular system and neurogenic inflammation are implicated in seizures. Emerging therapeutic targets, such as CGRP receptor antagonists, show efficacy in prevention. Conclusion: This review covers a comprehensive overview of neurobiological factors in migraine, highlighting the importance of understanding these mechanisms for more targeted therapies. This knowledge offers new perspectives for the effective management of this debilitating condition, improving patients' quality of life.
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