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NEUROBIOLOGICAL FACTORS INVOLVED IN MIGRAINE GENESIS

Authors

Ana Maria Santos Cardoso https://orcid.org/0000-0001-7092-2295
Vitória Miranda Eustáquio https://orcid.org/0009-0002-3096-4639
Waleska Vitória de Oliveira Tostes Peixoto https://orcid.org/0009-0003-5882-1450
Suzana Gabriela Ferreira Santos https://orcid.org/0009-0001-0435-2906
João Sérgio de Sousa Moura https://orcid.org/0009-0006-6962-0912
Antônio Valdir Soares de Sousa Júnior https://orcid.org/0009-0006-5814-8878
Larissa Nunes Castro https://orcid.org/0000-0001-5637-0578
Diego di Laurentis dos Santos Souza https://orcid.org/0009-0006-6262-8129
Gabriel Medeiros Oliveira Pires https://orcid.org/0009-0002-7311-3789
Amannda Maria Neiva dos Santos https://orcid.org/0009-0007-9688-0610

DOI:

https://doi.org/10.47820/recima21.v4i12.4089

Keywords:

Genetic factors; Neurotransmitters; Brain plasticity.

Abstract

Introduction: Migraine, one of the most prevalent and debilitating neurological conditions worldwide, has been the subject of intensive investigations aimed at understanding the complex neurobiological factors that contribute to its genesis. Objective: To investigate the neurobiological mechanisms of migraine and possible therapeutic approaches. Methodology: We performed a search in renowned scientific databases, including PubMed, Scopus and Web of Science, selecting studies published between 2013 and 2023 that addressed the neurobiological factors of migraine. Results and Discussion: We identified genetic influence, with variants such as MTHFR increasing the risk of migraine. Glutamatergic neurotransmission and central sensitization play crucial roles in generating pain. Activation of the trigemino-vascular system and neurogenic inflammation are implicated in seizures. Emerging therapeutic targets, such as CGRP receptor antagonists, show efficacy in prevention. Conclusion: This review covers a comprehensive overview of neurobiological factors in migraine, highlighting the importance of understanding these mechanisms for more targeted therapies. This knowledge offers new perspectives for the effective management of this debilitating condition, improving patients' quality of life.

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Author Biographies

Ana Maria Santos Cardoso

Instituto de Educação Superior do Vale do Parnaíba-IESVAP.

Vitória Miranda Eustáquio

Instituto de Educação Superior do Vale do Parnaíba-IESVAP.

Waleska Vitória de Oliveira Tostes Peixoto

Instituto de Educação Superior do Vale do Parnaíba-IESVAP.

Suzana Gabriela Ferreira Santos

Estácio - IDOMED.

João Sérgio de Sousa Moura

Instituto de Educação Superior do Vale do Parnaíba-IESVAP.

Antônio Valdir Soares de Sousa Júnior

Uninovafapi.

Larissa Nunes Castro

Uninovafapi.

Diego di Laurentis dos Santos Souza

Instituto de Educação Superior do Vale do Parnaíba-IESVAP.

Gabriel Medeiros Oliveira Pires

Instituto de Educação Superior do Vale do Parnaíba-IESVAP.

Amannda Maria Neiva dos Santos

Instituto de Educação Superior do Vale do Parnaíba-IESVAP.

References

ANTTILA, V.; WINSVOLD, B. S.; GORMLEY, P.; KURTH, T.; BETTELLA, F.; MCMAHON, G.; PALTA, P. Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nature Genetics, v. 45, n. 8, p. 912-917, 2017.

ASHINA, M.; GOADSBY, P. J.; REUTER, U. et al. Targeting the trigeminovascular pathway in migraine. Cephalalgia, v. 40, n. 12, p. 1485-1493, 2020.

CHARLES, A. Migraine: a brain state. Current Opinion in Neurology, v. 26, n. 3, p. 235-239, 2013.

CHONG, C. D.; SCHWEDT, T. J.; DODICK, D. W. Migraine: what imaging reveals. Neuroimaging Clinics of North America, v. 29, n. 4, p. 445-460, 2019.

COPPOLA, G.; DI RENZO, A.; TINELLI, E.; DI LORENZO, C.; SCAPECCIA, M.; PARISI, V.; PASCUAL, J. The CNS–peripheral nervous system relationship to the NMDA receptor in migraine: A review. The Journal of Headache and Pain, v. 16, n. 1, p. 1-9, 2015.

EDVINSSON, L.; WARFVINGE, K. Recognizing the role of CGRP and CGRP receptors in migraine and its treatment. Cephalalgia, v. 39, n. 3, p. 366-373, 2019.

GORMLEY, P.; ANTTILA, V.; WINSVOLD, B. S.; PALTA, P.; ESKO, T.; PERS, T. H.; TZOURIO, C. Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics, v. 48, n. 8, p. 856-866, 2016.

LEVY, D.; BURSTEIN, R.; KAINZ, V.; JAKUBOWSKI, M.; STRASSMAN, A. M. Mast cell degranulation activates a pain pathway underlying migraine headache. Pain, v. 159, n. 3, p. 193-208, 2018.

LIPTON, R. B.; DODICK, D. W.; SILBERSTEIN, S. D. et al. Guidelines for controlled trials of prophylactic treatment of chronic migraine in adults. Cephalalgia, v. 36, n. 10, p. 957-970, 2015.

LIPTON, R. B.; SILBERSTEIN, S. D. Episodic and chronic migraine headache: Breaking down barriers to optimal treatment and prevention. Headache: The Journal of Head and Face Pain, v. 55, n. S2, p. 103-122, 2015.

NOSEDA, R.; BURSTEIN, R. Migraine pathophysiology: Anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain. Pain, v. 154, n. Suppl 1, p. S44-S53, 2013.

NOSEDA, R.; SCHAIN, A. J.; MELO-CARRILLO, A. et al. Neural mechanism of migraine. Neuron, v. 109, n. 3, p. 406-420, 2021.

PEROUTKA, S. J. What turns on a migraine? A systematic review of migraine precipitating factors. Current Pain and Headache Reports, v. 18, n. 10, p. 454, 2014.

PIETROBON, D.; MOSKOWITZ, M. A. Pathophysiology of migraine. Annual Review of Physiology, v. 75, p. 365-391, 2013.

RUSSO, A. F.; KUNKEL, R. Calcitonin gene-related peptide (CGRP) and migraine. Handbook of Experimental Pharmacology, v. 255, p. 121-130, 2019.

RUSSO, A. F.; KUNKEL, R. Revisiting the Neurogenic Inflammation in Migraine. Neurotherapeutics, v. 16, n. 1, p. 15-24, 2019.

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Published

13/12/2023

How to Cite

Santos Cardoso, A. M., Miranda Eustáquio, V., Vitória de Oliveira Tostes Peixoto, W., Gabriela Ferreira Santos , S., Sérgio de Sousa Moura, J., Valdir Soares de Sousa Júnior, A., … Maria Neiva dos Santos, A. (2023). NEUROBIOLOGICAL FACTORS INVOLVED IN MIGRAINE GENESIS. RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 4(12), e4124089. https://doi.org/10.47820/recima21.v4i12.4089

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