DIAGNOSTIC AND THERAPEUTIC APPROACHES TO CUSHING'S SYNDROME: A LITERATURE REVIEW

Authors

DOI:

https://doi.org/10.47820/recima21.v5i3.5060

Keywords:

Cushing's syndrome. Pathophysiology. Therapeutic approach. Treatment. Diagnosis.

Abstract

Introduction: Cushing's Syndrome is a rare and complex endocrine condition characterized by a chronic increase in cortisol levels in the body, which can result in a variety of significant physical and metabolic symptoms. Objective: This study aims to explore recent advances and discoveries in the diagnosis and treatment of Cushing's Syndrome. Methods: A literature review of the last 15 years was carried out, including original studies and reviews, with specific inclusion criteria to address Cushing's Syndrome. Results and Discussion: The etiology of Cushing's Syndrome is multifaceted, reflecting the complexity of this endocrine condition. Standard diagnostic methods for Cushing's Syndrome include laboratory tests to evaluate cortisol and ACTH levels in blood, urine and saliva, as well as imaging tests to locate the source of hormone overproduction. Therapeutic options for Cushing's Syndrome, as evidenced by the review of current studies, present a wide range of approaches, including surgery, drug therapy and radiotherapy Conclusion: The review emphasizes the importance of education and awareness about Cushing's Syndrome among healthcare professionals. health, patients and caregivers, in order to facilitate early diagnosis, access to appropriate treatment and necessary emotional support.

Downloads

Download data is not yet available.

Author Biographies

Lucas Mainardo Rodrigues Bezerra

Instituto de Educação Superior do Vale do Parnaíba-IESVAP.

Taisnara Martins Oliveira

Acadêmica de Medicina.

Mariana de Arruda Frazão

Acadêmico(a) de Medicina.

Beatriz Calixtrato Pesconi

Acadêmico(a) de Medicina.

Igor Inácio Aragão

Acadêmico(a) de Medicina.

João Victor de Araújo Marques Alcântara

Acadêmico de Medicina.

Éric Moreira Menezes

Acadêmico de Medicina.

Rainally Sabrina Freire de Morais

Academica de Medicina.

Lorenna Kellyne Rodrigues Baldoino

Acadêmica de Medicina.

References

ALVES, Marta; NEVES, Celestino; MEDINA, J. Luís. Diagnóstico laboratorial de síndrome de Cushing. Acta Médica Portuguesa, v. 23, n. 1, p. 63-76, 2010.

CAI, Yunjia et al. Mechanism, diagnosis, and treatment of cyclic Cushing’s syndrome: A review. Biomedicine & Pharmacotherapy, v. 153, p. 113301, 2022. DOI: https://doi.org/10.1016/j.biopha.2022.113301

CASTINETTI, Frederic. Pharmacological Treatment of Cushing's Syndrome. Archives of Medical Research, p. 102908, 2023. DOI: https://doi.org/10.1016/j.arcmed.2023.102908

CRESPO, Letícia Rodrigues et al. Síndrome de Cushing: uma revisão narrativa. Revista Científica da Faculdade de Medicina de Campos, v. 16, n. 1, p. 74-78, 2021. DOI: https://doi.org/10.29184/1980-7813.rcfmc.495.vol.16.n1.2021

DAMASCENO, Sergio Augusto Nader et al. Síndrome de Cushing: Revisao Integrativa. Revista De Saúde, v. 10, n. 2, p. 76-81, 2019. DOI: https://doi.org/10.21727/rs.v10i2.2022

DEBONO, Miguel; NEWELL-PRICE, John D. Cushing's syndrome: where and how to find it. Cortisol Excess and Insufficiency, v. 46, p. 15-27, 2016. DOI: https://doi.org/10.1159/000443861

FERRIERE, Amandine; TABARIN, Antoine. Cushing's syndrome: treatment and new therapeutic approaches. Best Practice & Research Clinical Endocrinology & Metabolism, v. 34, n. 2, p. 101381, 2020. DOI: https://doi.org/10.1016/j.beem.2020.101381

FLESERIU, Maria et al. Consensus on diagnosis and management of Cushing's disease: a guideline update. The lancet Diabetes & endocrinology, v. 9, n. 12, p. 847-875, 2021.

FLESERIU, Maria. Cushing's syndrome Part 2: Advances in Treatment and in Understanding Complications’ Impact. Best Practice and Research: Clinical Endocrinology and Metabolism, v. 35, n. 2, p. 101523, 2021. DOI: https://doi.org/10.1016/j.beem.2021.101523

GUMASTE, Namrata et al. Evaluating Patient-Reported Outcomes in Cushing’s Syndrome. Endocrinology and Metabolism Clinics, v. 51, n. 4, p. 691-707, 2022. DOI: https://doi.org/10.1016/j.ecl.2022.05.002

HUANCA, Lizbeth Karen Mamani et al. Síndrome de Cushing por consumo excesivo de corticoesteroides. Current Opinion Nursing & Research, v. 3, n. 1, p. 16-26, 2021.

LIMA-MARTÍNEZ, Marcos M. et al. Manejo de pacientes con Síndrome de Cushing. Revista Venezolana de Endocrinología y Metabolismo, v. 11, n. 3, p. 147-156, 2013.

LUIZ, Henrique Vara et al. Síndrome de Cushing cíclica–apresentação de um caso clínico e revisão da literatura. Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo, v. 10, n. 2, p. 166-170, 2015. DOI: https://doi.org/10.1016/j.rpedm.2015.03.002

MC BRIDE, Margot et al. Quality of life in Cushing’s syndrome. Best Practice & Research Clinical Endocrinology & Metabolism, v. 35, n. 1, p. 101505, 2021. DOI: https://doi.org/10.1016/j.beem.2021.101505

RAFF, Hershel; CARROLL, Ty. Cushing's syndrome: from physiological principles to diagnosis and clinical care. The Journal of physiology, v. 593, n. 3, p. 493-506, 2015. DOI: https://doi.org/10.1113/jphysiol.2014.282871

ROBLES TORRES, Erick; LEAL CURI, Lisette; DÍAZ SOCORRO, Cossette. Tratamiento farmacológico del síndrome de Cushing. Revista Cubana de Endocrinología, v. 25, n. 3, p. 206-215, 2014.

SANTOS, Alicia; WEBB, Susan M.; RESMINI, Eugenia. Psychological complications of Cushing's syndrome. Current Opinion in Endocrinology, Diabetes and Obesity, v. 28, n. 3, p. 325-329, 2021. DOI: https://doi.org/10.1097/MED.0000000000000633

SANTOS, Silvia et al. Diagnóstico y diagnóstico diferencial del síndrome de Cushing. Endocrinología y Nutrición, v. 56, n. 2, p. 71-84, 2009. DOI: https://doi.org/10.1016/S1575-0922(09)70555-8

STARKER, Lee F.; KUNSTMAN, John W.; CARLING, Tobias. Subclinical Cushing syndrome: a review. Surgical Clinics, v. 94, n. 3, p. 657-668, 2014. DOI: https://doi.org/10.1016/j.suc.2014.02.008

WAGNER-BARTAK, Nicolaus A. et al. Cushing syndrome: diagnostic workup and imaging features, with clinical and pathologic correlation. American Journal of Roentgenology, v. 209, n. 1, p. 19-32, 2017. DOI: https://doi.org/10.2214/AJR.16.17290

WEKSLER, Felipe Lima et al. Abordagem geral das características da Síndrome de Cushing. Revista Eletrônica Acervo Saúde, v. 23, n. 5, p. e12852-e12852, 2023. DOI: https://doi.org/10.25248/reas.e12852.2023

Published

25/03/2024

How to Cite

Mainardo Rodrigues Bezerra, L., Martins Oliveira, T., de Arruda Frazão, M., Calixtrato Pesconi , B., Inácio Aragão, I., de Araújo Marques Alcântara , J. V., … Rodrigues Baldoino , L. K. (2024). DIAGNOSTIC AND THERAPEUTIC APPROACHES TO CUSHING’S SYNDROME: A LITERATURE REVIEW. RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 5(3), e535060. https://doi.org/10.47820/recima21.v5i3.5060