TIRZEPATIDE, A DUAL GIP AND GLP-1 RECEPTOR AGONIST, IN THE TREATMENT OF TYPE 2 DIABETES MELLITUS: EFFICACY AND SAFETY
DOI:
https://doi.org/10.47820/recima21.v5i4.5133Keywords:
Diabetes mellitus. Obesity, Treatment.Abstract
Introduction: Type 2 diabetes mellitus (DM2) is a chronic condition characterized by insulin resistance and deficiency in insulin production by the pancreas. Treatment of type 2 diabetes mellitus is generally individualized and aims to effectively control blood glucose levels, minimize complications and improve patients' quality of life. Tirzepatide is a bifunctional GLP-1 and glucagon receptor agonist with the potential to revolutionize the treatment of type 2 diabetes mellitus. Objectives: To provide a comprehensive overview of the role of tirzepatide in the current therapeutic arsenal of type 2 diabetes mellitus, focusing on its efficacy and security. Materials and methods: This is an integrative review, in which the guiding question was “Is tirzepatide safe and effective in the treatment of type 2 diabetes mellitus?”. The search for articles took place in the main databases (PubMed and Scielo) using the terms "tirzepatide", "treatment" and "type 2 diabetes" combined using Boolean operators. Results and discussion: Tirzepatide is the first dual receptor agonist that was recently approved for the treatment of T2DM by the Food Drug Administration (FDA). The efficacy in reducing blood glucose and body weight is stronger than that of GLP-1, while the safety profile and incidence of adverse events appear comparable. Conclusion: Tirzepatide is a new incretin-based therapy for T2DM, it has shown robust reductions in HbA1c and body weight, without an increased risk of hypoglycemia.
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