RELATIONSHIP BETWEEN HYPEROXIA AND MORTALITY IN MECHANICALLY VENTILATED ADULTS

Authors

DOI:

https://doi.org/10.47820/recima21.v5i8.5473

Keywords:

Oxygen. Hyperoxia. Oxygen. Critical Patient.

Abstract

The aim of this study was to evaluate the relationship between hyperoxia and mortality in adults on mechanical ventilation. Methods: Articles were included in electronic databases: Pubmed, SciElo and MedLine. originals indexed in Portuguese and English, in the period between January 1, 2012 and December 31, 2022. Randomized controlled trials, retrospective and prospective cohorts that evaluated the relationship between oxygen therapy and clinical outcomes such as mortality in critically ill patients were selected. Results: The analyzed studies presented divergent results regarding the ideal concentration of oxygen to be administered in critically ill patients, with evidence supporting the hypothesis that supplemental oxygen administration may be beneficial, as well as evidence showing that excess oxygen may be harmful. Most studies point to the need for individualized treatment based on oxygen saturation monitoring and clinical evaluation of the patient. Conclusion: Although there is divergence of results in the literature, it is consensus that oxygen administration in critically ill patients should be individualized and based on clinical evaluation and oxygen saturation monitoring. The hypothesis that supplemental oxygen administration may be harmful is plausible, and the definition of the ideal concentration should be done with caution. There is a need for better designed and larger sample studies to more precisely define the impact of oxygen therapy in critically ill patients.

Downloads

Download data is not yet available.

Author Biographies

Tacylla Gabriele da Silva Domingos

Pós-graduanda em fisioterapia cardiorrespiratória pela Faculdade Premier.

Thais da Conceição Fidelis de Souza

Pós-graduanda em fisioterapia cardiorrespiratória pela Faculdade Premier.

Nathália Guimarães Assis

Pós-graduanda em fisioterapia cardiorrespiratória pela Faculdade Premier.

Thamirys Martins Tereza

Pós-graduanda em fisioterapia cardiorrespiratória pela Faculdade Premier.

Isabela Oliveira Dias

Pós-graduanda em fisioterapia cardiorrespiratória pela Faculdade Premier.

Xisto Sena Passos

Doutor em Medicina Tropical pela Universidade Federal de Goiás – Professor da Pós-Graduação e Pesquisa da Faculdade Premier.

Linda Denise Fernandes Moreira

Doutora em Ciências pela UNIFESP e Diretora de Pós-Graduação e Pesquisa da Faculdade Premier.

Cristina de Sousa Dias

Mestre em Atenção à Saúde Pública pela Pontifícia Católica de Goiás – Professora da Pós-Graduação e Pesquisa da Faculdade Premier.

References

ALMEIDA, T. DE; MENDES, B.; BRUNO, P. et al. Adjustment of oxygen use by means of pulse oximetry: an important tool for patient safety. Einstein, v. 8, p. 449–55, 2010. DOI: https://doi.org/10.1590/s1679-45082010ao1377

BÄCKLUND, M.; KEUS, F.; LAAKE, J. H. et al. Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure. The New England Journal of Medicine, v. 25, n. 1, p. 1301–11, 2021.

BELLANI, G.; LAFFEY, J. G.; PHAM, T. et al. Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. JAMA, v. 315, n. 8, p. 788–800, 2016. DOI: https://doi.org/10.1001/jama.2016.0291

CRISTINA, K.; BRANDÃO, G.; FAGUNDES, L. Ventilação mecânica. VITALLE, Revista de Ciências da Saúde, v. 1, p. 173–84, 2020. DOI: https://doi.org/10.14295/vittalle.v33i1.11579

GELISSEN, H.; GROOTH, H.-J. DE; SMULDERS, Y. et al. Effect of Low-Normal vs High-Normal Oxygenation Targets on Organ Dysfunction in Critically Ill Patients: A Randomized Clinical Trial. JAMA, v. 326, n. 10, p. 940–8, 2021. DOI: https://doi.org/10.1001/jama.2021.13011

GIRARDIS, M.; BUSANI, S.; DAMIANI, E. et al. Effect of Conservative vs Conventional Oxygen Therapy on Mortality Among Patients in an Intensive Care Unit: The Oxygen-ICU Randomized Clinical Trial. JAMA, v. 316, n. 15, p. 1583-9, 2016. DOI: https://doi.org/10.1001/jama.2016.11993

GRASIELA, C.; OLIVEIRA, S. DE. Hipotermia terapêutica em pacientes pós-parada cardiorrespiratória: mecanismos de ação e desenvolvimento de protocolo assistencial. Revista Brasileira de Terapia Intensiva, v. 22, n. 2, p. 203-18, 1980.

KALLET, R. H.; FAARC, R. R. T.; BRANSON, R. D.; FAARC, R. R. T. Should Oxygen Therapy Be Tightly Regulated to Minimize Hyperoxia in Critically Ill Patients? Respitory Care, v. 61, n. 6, p. 801-17, 2016. DOI: https://doi.org/10.4187/respcare.04933

KIM, T. Y.; KIM, D. H.; KIM, S. C. et al. Impact of early hyperoxia on 28-day in- hospital mortality in patients with myocardial injury. PLOS One, v. 55, n. 8, p. 1-16, 2018. DOI: https://doi.org/10.1371/journal.pone.0201286

KNAUS, W. A.; DRAPER, E. A.; WAGNER, D. P.; ZIMMERMAN, J. E. APACHE II: a severity of disease classification system. Critical Care Medicine, v. 13, n. 10, p. 818–29, 1985. DOI: https://doi.org/10.1097/00003246-198510000-00009

NI, Y.; WANG, Y.; LIANG, B.; LIANG, Z. The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis. BMC Pulmonary Medicine, v. 19, n. 53, p. 1-11, 2019. DOI: https://doi.org/10.1186/s12890-019-0810-1

PAGE, D.; ABLORDEPPEY, E.; WESSMAN, B. T. et al. Emergency department hyperoxia is associated with increased mortality in mechanically ventilated patients: a cohort study. Critical Care (London, England), v. 22, n. 1, p. 9-16, 2018. DOI: https://doi.org/10.1186/s13054-017-1926-4

PANNU, S. R. Too Much Oxygen: Hyperoxia and Oxygen Management in Mechanically Ventilated Patients. Semin Respir Crit Care Med, v. 37, n. 01, p. 16–22, 2016. DOI: https://doi.org/10.1055/s-0035-1570359

PANWAR, R.; HARDIE, M.; BELLOMO, R.; EASTWOOD, G. M.; YOUNG, P. J. Conservative versus Liberal Oxygenation Targets for Mechanically Ventilated Patients. American Journal of Respiratory and Critical Care Medicine, v. 193, n. 1, p. 43–51, 2016. DOI: https://doi.org/10.1164/rccm.201505-1019OC

RUSSELL, D. W.; JANZ, D. R.; EMERSON, W. L. et al. Early exposure to hyperoxia and mortality in critically ill patients with severe traumatic injuries. BMC Pulmonary Medicine, v. 17, n. 29, p. 1–7, 2017. DOI: https://doi.org/10.1186/s12890-017-0370-1

SCHJØRRING, O. L.; KLITGAARD, T. L.; PERNER, A. et al. Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure. The New England Journal of Medicine, v. 384, n. 14, p. 1301-11, 2021.

SHAEFI, S.; BRENNER, S. K.; GUPTA, S. et al. Extracorporeal membrane oxygenation in patients with severe respiratory failure from COVID ‑ 19. Intensive Care Med, v. 47, n. 1, p. 208–21, 2021. DOI: https://doi.org/10.1007/s00134-020-06331-9

SOUZA, K. DE; CÓRDOVA, P. A.; CARVALHO, J. C. DE. Adequações dos dispositivos de oxigenoterapia em enfermaria hospitalar avaliadas por oximetria de pulso e gasometria arterial. ASSOBRAFIR Ciência, v. 5, n. 1, p. 53–64, 2014.

Downloads

Published

15/08/2024

How to Cite

da Silva Domingos, T. G., da Conceição Fidelis de Souza, T., Guimarães Assis, N., Martins Tereza, T., Oliveira Dias, I., Sena Passos, X., … de Sousa Dias, C. (2024). RELATIONSHIP BETWEEN HYPEROXIA AND MORTALITY IN MECHANICALLY VENTILATED ADULTS. RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 5(8), e585473. https://doi.org/10.47820/recima21.v5i8.5473

Issue

Vol. 5 No. 8 (2024): CLICK HERE TO ACCESS THE ARTICLES

Section

ARTIGOS

Categories

License

Copyright (c) 2024 RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Os direitos autorais dos artigos/resenhas/TCCs publicados pertecem à revista RECIMA21, e seguem o padrão Creative Commons (CC BY 4.0), permitindo a cópia ou reprodução, desde que cite a fonte e respeite os direitos dos autores  e contenham menção aos mesmos nos créditos. Toda e qualquer obra publicada na revista, seu conteúdo é de responsabilidade dos autores, cabendo a RECIMA21 apenas ser o veículo de divulgação, seguindo os padrões nacionais e internacionais de publicação.