PROBIÓTICOS EN EL TRATAMIENTO DEL MIELOMA MÚLTIPLE: UNA REVISIÓN
DOI:
https://doi.org/10.47820/recima21.v5i6.5340Palabras clave:
Enfermedades oncohematológicas. Microbioma intestinal. Microbiología.Resumen
El mieloma múltiple (MM) es la segunda neoplasia hematológica más común, caracterizada por la proliferación descontrolada de células plasmáticas, lo que resulta en complicaciones como anemia, lesiones óseas e insuficiencia renal. Estudios sugieren que la microbiota intestinal puede influir en la progresión del MM y en la respuesta al tratamiento. En este contexto, los probióticos, conocidos por sus beneficios para la salud intestinal, presentan potencial terapéutico para el tratamiento del MM, mejorando la microbiota y la respuesta inmunológica. Por lo tanto, el objetivo fue realizar una revisión sistemática a través del Methodi Ordinatio sobre el potencial uso de probióticos en el tratamiento del mieloma múltiple. Las búsquedas se llevaron a cabo en el mes de abril de 2024, en las bases de datos: Embase, Scopus y Web of Science. No se utilizaron intervalos temporales. La búsqueda arrojó un total de 104 publicaciones, de las cuales 2 cumplieron con los criterios de selección. Las publicaciones datan de 2018 y 2024. El mayor valor InOrd fue alcanzado por la revista Cell Metabolism, mientras que la revista Probiotics and Antimicrobial Proteins presentó el mayor número de citas. Ambas revistas tienen un alto factor de impacto. Evidencias preliminares sugieren que los prebióticos pueden desencadenar efectos inmunomoduladores y antiinflamatorios, mejorando la condición general de los pacientes. Estudios indican que el desequilibrio de la microbiota intestinal puede influir en la progresión de la enfermedad y en la eficacia del tratamiento, resaltando la necesidad de más investigaciones en este campo.
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