PROBIOTICS IN THE TREATMENT OF MULTIPLE MYELOMA: A REVIEW

Authors

  • Ana Savia Cardoso Brito
  • Gildeanni Iasmim Alves Vieira
  • Alessandra Souza dos Santos
  • Aroldo Mazur Barbosa da Silva

DOI:

https://doi.org/10.47820/recima21.v5i6.5340

Keywords:

Oncohematological diseases. Intestinal microbiome. Microbiology.

Abstract

Multiple myeloma (MM) is the second most common hematologic malignancy, characterized by the uncontrolled proliferation of plasma cells, resulting in complications such as anemia, bone lesions, and renal failure. Studies suggest that the intestinal microbiota may influence the progression of MM and response to treatment. In this context, probiotics, known for their benefits to intestinal health, present therapeutic potential for MM treatment by improving microbiota and immune response. Therefore, the aim was to conduct a systematic review using the Methodi Ordinatio on the potential use of probiotics in the treatment of multiple myeloma. Searches were conducted in April 2024 in the databases: Embase, Scopus, and Web of Science. No temporal intervals were employed. The search resulted in a total of 104 publications, of which 2 met the selection criteria. The publications date from 2018 and 2024. The highest InOrd value was achieved by the journal Cell Metabolism, while the journal Probiotics and Antimicrobial Proteins had the highest number of citations. Both journals had a high impact factor. Preliminary evidence suggests that prebiotics may trigger immunomodulatory and anti-inflammatory effects, improving overall patient condition. Studies indicate that imbalance in the intestinal microbiota may influence disease progression and treatment efficacy, highlighting the need for further investigations in this field.

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Author Biographies

Ana Savia Cardoso Brito

Graduanda em Biomedicina pelo Centro Universitário das Faculdades Metropolitanas Unidas - FMU, São Paulo, São Paulo, Brasil.

Gildeanni Iasmim Alves Vieira

Mestranda em Biotecnologia pela Universidade Federal do Delta do Parnaíba - UFDPar, Parnaíba, Piauí, Brasil. Graduada em Licenciatura Plena em Ciências Biológicas pela Universidade Federal do Piauí - UFPI.

Alessandra Souza dos Santos

Mestranda em Biotecnologia pela Universidade Federal do Delta do Parnaíba - UFDPar, Parnaíba, Piauí, Brasil. Especialista em Biodiversidade e Conservação pela Universidade Estadual do Piauí - UESPI. Graduada em Licenciatura Plena em Ciências Biológicas pela Universidade Federal do Piauí - UFPI.

Aroldo Mazur Barbosa da Silva

Docente do curso de Biomedicina pela Faculdade Estácio de Sá, Carapicuíba, São Paulo, Brasil. Especialista em Docência do Ensino Superior com Ênfase em Sistema de Saúde pela Faculdade Venda Nova do Imigrante - FAVENI. Especialista em Imagenologia pela Universidade Nove de Julho, UNINOVE. Graduado em Biomedicina pela Inaci Associação de Ensino, IAE.

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Published

07/06/2024

How to Cite

Cardoso Brito, A. S., Alves Vieira, G. I., Souza dos Santos, A., & Barbosa da Silva, A. M. (2024). PROBIOTICS IN THE TREATMENT OF MULTIPLE MYELOMA: A REVIEW. RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 5(6), e565340. https://doi.org/10.47820/recima21.v5i6.5340

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