PRODUCTOS NATURALES CON ACTIVIDAD ANTICANCERÍGENA: UNA REVISIÓN DE ENSAYOS DE ACOPLAMIENTO IN VITRO, IN VIVO Y MOLECULAR
DOI:
https://doi.org/10.47820/recima21.v3i1.899Palabras clave:
Natural products, Antitumor activity, In vivo evaluationResumen
Los productos naturales se utilizan cada vez más en la investigación científica en un intento de obtener nuevos fármacos para las enfermedades actuales. La mayoría de las veces, estas sustancias están presentando buenos resultados, además de presentar algunos puntos positivos como la fácil adquisición, el bajo costo y el menor o nulo efecto adverso. En este sentido, el objetivo de esta investigación es realizar un estudio bibliográfico sobre los estudios in vitro, in vivo e in silico de productos naturales para demostrar su actividad antitumoral. El estudio es una investigación de revisión que utilizó 31 artículos para destacar los hallazgos científicos sobre la actividad antitumoral de los productos naturales y sus derivados. Los artículos se incluyeron en la estimación temporal entre 2015 - 2021 (últimos seis años). La búsqueda y selección de los estudios de referencia se realizó en las bases de datos Scielo, Science Direct, PubMed y Google Academic. La literatura muestra que los compuestos naturales presentan diversas actividades contra varios tipos de cáncer, como el de mama, próstata, hígado, páncreas, colorrectal, entre otros. Los estudios encontrados sugieren que la diversidad de compuestos existentes puede desencadenar pasos importantes hacia la optimización de nuevas estrategias de formulación de fármacos para la quimioterapia del cáncer. Así pues, pueden ser importantes nuevos estudios para dilucidar aún más específicamente los efectos de estos compuestos aislados y en asociación in vivo para el descubrimiento de nuevos tratamientos contra el cáncer.
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Derechos de autor 2022 RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218
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