PRODUCTOS NATURALES CON ACTIVIDAD ANTICANCERÍGENA: UNA REVISIÓN DE ENSAYOS DE ACOPLAMIENTO IN VITRO, IN VIVO Y MOLECULAR

Autores/as

DOI:

https://doi.org/10.47820/recima21.v3i1.899

Palabras clave:

Natural products, Antitumor activity, In vivo evaluation

Resumen

Los productos naturales se utilizan cada vez más en la investigación científica en un intento de obtener nuevos fármacos para las enfermedades actuales. La mayoría de las veces, estas sustancias están presentando buenos resultados, además de presentar algunos puntos positivos como la fácil adquisición, el bajo costo y el menor o nulo efecto adverso. En este sentido, el objetivo de esta investigación es realizar un estudio bibliográfico sobre los estudios in vitro, in vivo e in silico de productos naturales para demostrar su actividad antitumoral. El estudio es una investigación de revisión que utilizó 31 artículos para destacar los hallazgos científicos sobre la actividad antitumoral de los productos naturales y sus derivados. Los artículos se incluyeron en la estimación temporal entre 2015 - 2021 (últimos seis años). La búsqueda y selección de los estudios de referencia se realizó en las bases de datos Scielo, Science Direct, PubMed y Google Academic. La literatura muestra que los compuestos naturales presentan diversas actividades contra varios tipos de cáncer, como el de mama, próstata, hígado, páncreas, colorrectal, entre otros. Los estudios encontrados sugieren que la diversidad de compuestos existentes puede desencadenar pasos importantes hacia la optimización de nuevas estrategias de formulación de fármacos para la quimioterapia del cáncer. Así pues, pueden ser importantes nuevos estudios para dilucidar aún más específicamente los efectos de estos compuestos aislados y en asociación in vivo para el descubrimiento de nuevos tratamientos contra el cáncer.

Descargas

Los datos de descargas todavía no están disponibles.

Biografía del autor/a

Daniel Lopes Araújo

Universidade Federal de Pernambuco

Tiago Tavares Gonçalves

Universidade de Rio Verde - UniRV - Campus Aparecida

Citas

AHMAD, Irfan et al. Phytochemical screening and in-vitro antibacterial and anticancer activity of crude extract of Matricaria aurea. Current Pharmaceutical Design, v. 27, n. 1, p. 69-79, 2021.

COLONE, Marisa; CALCABRINI, Annarica; STRINGARO, Annarita. Drug delivery systems of natural products in oncology. Molecules, v. 25, n. 19, p. 4560, 2020.

CORDEIRO, Laísa Vilar et al. Association of carvacrol with ceftazidime and cefepime against Klebsiella pneumoniae. Research, Society and Development, v. 9, n. 7, p. e264974089-e264974089, 2020.

COSTA, Ana Carla Ferreira; CAVALCANTE, Giani Maria. Atividade antitumoral in vitro de prosopis juliflora frente a células de câncer de mama e câncer de ovário. Acta Biomédica Brasiliensia, v. 9, n. 1, p. 130-136, 2018.

DE MORAES, Josué. Natural products with antischistosomal activity. Future Medicinal Chemistry, v. 7, n. 6, p. 801-820, 2015.

EL-HOSSARY, Ebaa M. et al. Antifungal potential of marine natural products. European journal of medicinal chemistry, v. 126, p. 631-651, 2017.

ESPINOSA-RODRIGUEZ, Bryan Alejandro et al. Comparative Anticancer Activity and Molecular Docking of Different Isatin-Based Scaffolds. Anticancer Research, v. 41, n. 10, p. 4969-4977, 2021.

GALÚCIO, João Marcos et al. In silico identification of natural products with anticancer activity using a chemo-structural database of Brazilian biodiversity. Computational biology and chemistry, v. 83, p. 107102, 2019.

HERNÁNDEZ-RODRÍGUEZ, Maricarmen et al. In vitro and computational studies of natural products related to perezone as anti-neoplastic agents. Biochimie, v. 171, p. 158-169, 2020.

IQBAL, Tahseen et al. Natural products based crown ethers: synthesis and their anticancer potential. Journal of Asian Natural Products Research, p. 1-9, 2021.

KHAN, Abdul Q.; UDDIN, Shahab. Anticancer Activity of Natural Compounds. Asian Pacific Journal of Cancer Prevention, v. 21, n. 2, p. 1-2, 2021.

KIM, Michael et al. Screening and Evaluation of Natural Product Derivative Library for Anticancer Activity in Human Prostate Cancer Cells. The FASEB Journal, v. 35.

HUANG, Gangliang; MEI, Xinya; HU, Jinchuan. The antioxidant activities of natural polysaccharides. Current drug targets, v. 18, n. 11, p. 1296-1300, 2017.

HUANG, Yuzhou et al. Structure-based virtual screening of natural products as potential stearoyl-coenzyme a desaturase 1 (SCD1) inhibitors. Computational biology and chemistry, v. 86, p. 107263, 2020.

JIANG, Yu; FAN, Liuping. Evaluation of anticancer activities of Poria cocos ethanol extract in breast cancer: In vivo and in vitro, identification and mechanism. Journal of ethnopharmacology, v. 257, p. 112851, 2020.

KI, Hyeon-Hui et al. In vitro and in vivo anti-cancer activity of dichloromethane fraction of Triticum aestivum sprouts. Biomedicine & Pharmacotherapy, v. 96, p. 120-128, 2017.

LANG, Sophia J. et al. Antitumor activity of an Artemisia annua herbal preparation and identification of active ingredients. Phytomedicine, v. 62, p. 152962, 2019.

LIN, Tzu-Kai; ZHONG, Lily; SANTIAGO, Juan Luis. Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International journal of molecular sciences, v. 19, n. 1, p. 70, 2018.

MALYARENKO, Olesya S.; IMBS, Tatiana I.; ERMAKOVA, Svetlana P. In Vitro Anticancer and Radiosensitizing Activities of Phlorethols from the Brown Alga Costaria costata. Molecules, v. 25, n. 14, p. 3208, 2020.

MUNARI, Eduarda Laís et al. Potencial antitumoral de extratos de Eugenia involucrata DC: uso de produtos regionais para tratar um problema mundial. 2021.

NEWMAN, David J.; CRAGG, Gordon M. Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019. Journal of Natural Products, v. 83, n. 3, p. 770-803, 2020.

NGUYEN, Ngoc Hong et al. Anticancer activity of novel plant extracts and compounds from Adenosma bracteosum (Bonati) in human lung and liver cancer cells. Molecules, v. 25, n. 12, p. 2912, 2020.

RAYAN, Anwar; RAIYN, Jamal; FALAH, Mizied. Nature is the best source of anticancer drugs: Indexing natural products for their anticancer bioactivity. PloS one, v. 12, n. 11, p. e0187925, 2017.

RYU, Mina et al. Activation of JNK and p38 in MCF-7 Cells and the in vitro anticancer activity of Alnus hirsuta extract. Molecules, v. 25, n. 5, p. 1073, 2020.

SAHYON, Heba A.; AL-HARBI, Sami A. Antimicrobial, anticancer and antioxidant activities of nano-heart of Phoenix dactylifera tree extract loaded chitosan nanoparticles: In vitro and in vivo study. International Journal of Biological Macromolecules, v. 160, p. 1230-1241, 2020.

SAIKIA, Surovi et al. Marine steroids as potential anticancer drug candidates: In silico investigation in search of inhibitors of Bcl-2 and CDK-4/Cyclin D1. Steroids, v. 102, p. 7-16, 2015.

SOLTANA, Hala et al. Antitumoral activity of Ficus carica L. on colorectal cancer cell lines. Cellular and Molecular Biology, v. 65, n. 6, p. 6-11, 2019.

SUBBURAJ, Saranyadevi et al. Discovery of anaplastic lymphoma kinase inhibitors from natural product library: A holistic in silico approach. Biotechnology and Applied Biochemistry, 2020.

VUONG, Thu V. Natural Products and Their Derivatives with Antibacterial, Antioxidant and Anticancer Activities. 2021.

ZHANG, Jian-ye et al. Structure identification and in vitro anticancer activity of lathyrol-3-phenylacetate-5, 15-diacetate. Molecules, v. 22, n. 9, p. 1412, 2017.

WAKS, Adrienne G.; WINER, Eric P. Breast cancer treatment: a review. Jama, v. 321, n. 3, p. 288-300, 2019.

Descargas

Publicado

17/01/2022

Cómo citar

Lopes Araújo, D., Osvaldo de Sousa, E., Clementino da Silva Sousa, L., Gomes Sousa, B., Bruno Brito Cerqueira, D., Fellipe Capini de Almeida Tavares, E., … Tavares Gonçalves, T. (2022). PRODUCTOS NATURALES CON ACTIVIDAD ANTICANCERÍGENA: UNA REVISIÓN DE ENSAYOS DE ACOPLAMIENTO IN VITRO, IN VIVO Y MOLECULAR. RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 3(1), e31899. https://doi.org/10.47820/recima21.v3i1.899