ÔMEGA-3 E ASPIRINA COMO ADJUVANTES NO TRATAMENTO PERIODONTAL: REVISÃO DE LITERATURA

Autores

DOI:

https://doi.org/10.47820/recima21.v3i5.1295

Palavras-chave:

Ácidos graxos poli-insaturados, ácido acetilsalicílico, tratamento periodontal

Resumo

Estudos sobre os efeitos de metabólitos das lipoxinas (ácido araquidônico) e de ácidos graxos poli-insaturados do ômega-3 (ω-3) em associação aos efeitos de potencialização do ácido acetilsalicílico (ASA) na modulação e resolução inflamatória da doença periodontal, evidenciaram resultados benéficos como terapia adjuvante ao tratamento da doença periodontal. O presente estudo se propõe a revisar a literatura atual sobre os efeitos do ω-3 e sua combinação com ASA no tratamento da doença periodontal. Estudos clínicos randomizados controlados por placebo de desenhos paralelos e duplo-cegos foram utilizados como base literária para essa revisão de literatura. Os dados obtidos demonstram melhorias nos parâmetros clínicos periodontais, na diminuição dos níveis de biomarcadores pró-inflamatórios e na modulação e resolução da resposta inflamatória da doença periodontal, evidenciando uma favorável intervenção na condição inflamatória. Nota-se que a terapia de imunomodulação do hospedeiro com ω-3 demonstra benefícios nos parâmetros clínicos e inflamatórios de acordo com a literatura atual.

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Biografia do Autor

Rafael Nascimento de Brito Silva

Graduado em Odontologia pela Universidade Guarulhos. Atualmente, é mestrando em periodontia no programa de pós-graduação da Universidade Guarulhos.

Nidia Castro dos Santos

Dra. Castro dos Santos completou sua graduação em Odontologia na Universidade Estadual Paulista (UNESP) em São José dos Campos. É especialista em Periodontia. Possui mestrado em Microbiologia e Imunologia e doutorado em Periodontia pela UNESP. Realizou estágio de doutoramento no Forsyth Institute (Estados Unidos), no Centro de Pesquisa Clínica e Translacional, e pós-doutorado em Periodontia na Universidade Guarulhos. Atualmente é docente permanente do Programa de Pós-graduação em Odontologia na Universidade Guarulhos.

Magda Feres

Dra. Feres é periodontista (especialização e mestrado), Doutora em Biologia Oral pela Universidade de Harvard (EUA) e Pós-doutora em Microbiologia pelo Forsyth Institute (EUA). Ela é a coordenadora do Programa de Pós-Graduação em Odontologia da Universidade Guarulhos (único programa em Universidade particular com nota de excelência da CAPES) e Associate Professor do Forsyth.

Referências

World Health Organization. (2003). The World Oral Health Report 2003. Community Dentistry and Oral Epidemiology, 31 Suppl 1, 3–23. https://doi.org/10.1046/j.2003.com122.x.

Bartold, P. M., & Van Dyke, T. E. (2013). Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts. Periodontology 2000, 62(1), 203–217. https://doi.org/10.1111/j.1600-0757.2012.00450.x.

Castro dos Santos NC, Andere NMRB, Araujo CF, et al. Omega-3 PUFA and aspirin as adjuncts to periodontal debridement in patients with periodontitis and type 2 diabetes mellitus: Randomized clinical trial. J Periodontol. 2020;1– 10. https://doi.org/10.1002/JPER.19-0613.

Petersen, P. E., & Ogawa, H. (2005). Strengthening the Prevention of Periodontal Disease: The WHO Approach. Journal of Periodontology, 76(12), 2187–2193. https://doi.org/10.1902/jop.2005.76.12.2187.

Linden, G. J., Linden, K., Yarnell, J., Evans, A., Kee, F., & Patterson, C. C. (2012). All-cause mortality and periodontitis in 60-70-year-old men: A prospective cohort study. Journal of Clinical Periodontology, 39(10), 940–946. https://doi.org/10.1111/j.1600-051X.2012.01923.x.

Buset, S. L., Walter, C., Friedmann, A., Weiger, R., Borgnakke, W. S., & Zitzmann, N. U. (2016). Are periodontal diseases really silent? A systematic review of their effect on quality of life. Journal of Clinical Periodontology, 43(4), 333–344. https://doi.org/10.1111/jcpe.12517.

Dietrich, T., Jimenez, M., Kaye, E. A. K., Vokonas, P. S., & Garcia, R. I. (2008). Age-dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease. Circulation, 117(13), 1668–1674. https://doi.org/10.1161/CIRCULATIONAHA.107.711507.

Tonetti, M. S., & Van Dyke, T. E. (2013). Periodontitis and atherosclerotic cardiovascular disease: Consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. Journal of Clinical Periodontology, 40(SUPPL. 14), 24–29. https://doi.org/10.1111/jcpe.12089.

Hasturk, H., Kantarci, A., Ohira, T., Arita, M., Ebrahimi, N., Chiang, N., Petasis, N. A., Levy, B. D., Serhan, C. N., & Van Dyke, T. E. (2006). RvE1 protects from local inflammation and osteoclastmediated bone destruction in periodontitis. The FASEB Journal, 20(2), 401–403. https://doi.org/10.1096/fj.05-4724fje.

Haffajee, A. D., Cugini, M. A., Dibart, S., Smith, C., Kent, R. L., & Socransky, S. S. (1997). The effect of SRP on the clinical and microbiological parameters of periodontal diseases. Journal of Clinical Periodontology, 24(5), 324–334. https://doi.org/10.1111/j.1600-051x.1997.tb00765.x.

Cugini, M. A., Haffajee, A. D., Smith, C., Kent, R. L., & Socransky, S. S. (2000). The effect of scaling and root planing on the clinical and microbiological parameters of periodontal diseases: 12-month results. Journal of Clinical Periodontology, 27(1), 30–36. https://doi.org/10.1034/j.1600-051x.2000.027001030.x.

Sampaio, E., Rocha, M., Figueiredo, L. C., Faveri, M., Duarte, P. M., Gomes Lira, E. A., & Feres, M. (2011). Clinical and microbiological effects of azithromycin in the treatment of generalized chronic periodontitis: A randomized placebo-controlled clinical trial. Journal of Clinical Periodontology, 38(9), 838–846. https://doi.org/10.1111/j.1600-051X.2011.01766.x.

Herrera, D., Sanz, M., Jepsen, S., Needleman, I., & Roldan, S. (2002). A systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planing in periodontitis patients. Journal of Clinical Periodontology, 29(s3), 136–159. https://doi.org/10.1034/j.1600-051x.29.s3.8.x.

Haffajee, A. D., Socransky, S. S., & Gunsolley, J. C. (2003). Systemic anti-infective periodontal therapy. A systematic review. Annals of Periodontology / the American Academy of Periodontology, 8(1), 115–181. https://doi.org/10.1902/annals.2003.8.1.115.

Sgolastra, F., Gatto, R., Petrucci, A., & Monaco, A. (2012). Effectiveness of Systemic Amoxicillin/Metronidazole as Adjunctive Therapy to Scaling and Root Planing in the Treatment of Chronic Periodontitis: A Systematic Review and Meta-Analysis. Journal of Periodontology, 83(10), 1257–1269. https://doi.org/10.1902/jop.2012.110625.

Sgolastra, F., Petrucci, A., Gatto, R., & Monaco, A. (2012). Effectiveness of Systemic Amoxicillin/Metronidazole as an Adjunctive Therapy to Full-Mouth Scaling and Root Planing in the Treatment of Aggressive Periodontitis: A Systematic Review and Meta-Analysis. Journal of Periodontology, 83(6), 731–743. https://doi.org/10.1902/jop.2011.110432.

Zandbergen, D., Slot, D. E., Cobb, C. M., & Van der Weijden, F. A. (2013). The Clinical Effect of Scaling and Root Planing and the Concomitant Administration of Systemic Amoxicillin and Metronidazole: A Systematic Review. Journal of Periodontology, 84(3), 332–351. https://doi.org/10.1902/jop.2012.120040.

Keestra, J. A. J., Grosjean, I., Coucke, W., Quirynen, M., & Teughels, W. (2015). Non-surgical periodontal therapy with systemic antibiotics in patients with untreated aggressive periodontitis: A systematic review and meta-analysis. Journal of Periodontal Research, 50(6), 689–706. https://doi.org/10.1111/jre.12252.

Keestra, J. A. J., Grosjean, I., Coucke, W., Quirynen, M., & Teughels, W. (2015). Non-surgical periodontal therapy with systemic antibiotics in patients with untreated chronic periodontitis: A systematic review and meta-analysis. Journal of Periodontal Research, 50(3), 294–314. https://doi.org/10.1111/jre.12221.

Feres, M., Figueiredo, L. C., Soares, G. M. S., & Faveri, M. (2015). Systemic antibiotics in the treatment of periodontitis. Periodontology 2000, 67(1), 131–186. https://doi.org/10.1111/prd.12075.

Matarazzo, F., Figueiredo, L. C., Cruz, S. E. B., Faveri, M., & Feres, M. (2008). Clinical and microbiological benefits of systemic metronidazole and amoxicillin in the treatment of smokers with chronic periodontitis: A randomized placebo-controlled study. Journal of Clinical Periodontology, 35(10), 885–896. https://doi.org/10.1111/j.1600-051X.2008.01304.x.

Cionca, N., Giannopoulou, C., Ugolotti, G., & Mombelli, A. (2009). Amoxicillin and Metronidazole as an Adjunct to Full-Mouth Scaling and Root Planing of Chronic Periodontitis. Journal of Periodontology, 80(3), 364–371. https://doi.org/10.1902/jop.2009.080540.

Mestnik, M. J., Feres, M., Figueiredo, L. C., Duarte, P. M., Lira, E. A. G., & Faveri, M. (2010). Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis. Journal of Clinical Periodontology, 37(4), 353–365. https://doi.org/10.1111/j.1600-051X.2010.01538.x.

Mestnik, M. J., Feres, M., Figueiredo, L. C., Soares, G., Teles, R. P., Fermiano, D., Duarte, P. M., & Faveri, M. (2012). The effects of adjunctive metronidazole plus amoxicillin in the treatment of generalized aggressive periodontitis: A 1-year double-blinded, placebo-controlled, randomized clinical trial. Journal of Clinical Periodontology, 39(10), 955–961. https://doi.org/10.1111/j.1600-051X.2012.01932.x.

Feres, M., Soares, G. M. S., Mendes, J. A. V., Silva, M. P., Faveri, M., Teles, R., Socransky, S. S., & Figueiredo, L. C. (2012). Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: A 1-year double-blinded, placebo-controlled, randomized clinical trial. Journal of Clinical Periodontology, 39(12), 1149–1158. https://doi.org/10.1111/jcpe.12004.

Goodson, J. M., Haffajee, A. D., Socransky, S. S., Kent, R., Teles, R., Hasturk, H., Bogren, A., Van Dyke, T., Wennstrom, J., & Lindhe, J. (2012). Control of periodontal infections: A randomized controlled trial I. the primary outcome attachment gains and pocket depth reduction at treated sites. Journal of Clinical Periodontology, 39(6), 526–536. https://doi.org/10.1111/j.1600-051X.2012.01870.x.

Soares, G. M. S., Mendes, J. A. V., Silva, M. P., Faveri, M., Teles, R., Socransky, S. S., Wang, X., Figueiredo, L. C., & Feres, M. (2014). Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: A secondary analysis of microbiological results from a randomized clinical trial. Journal of Clinical Periodontology, 41(4), 366–376. https://doi.org/10.1111/jcpe.12217.

Miranda, T. S., Feres, M., Perez-Chaparro, P. J., Faveri, M., Figueiredo, L. C., Tamashiro, N. S., Bastos, M. F., & Duarte, P. M. (2014). Metronidazole and amoxicillin as adjuncts to scaling and root planing for the treatment of type 2 diabetic subjects with periodontitis: 1-year outcomes of a randomized placebo-controlled clinical trial. Journal of Clinical Periodontology, 41(9), 890–899. https://doi.org/10.1111/jcpe.12282.

Harks, I., Koch, R., Eickholz, P., Hoffmann, T., Kim, T. S., Kocher, T., Meyle, J., Kaner, D., Schlagenhauf, U., Doering, S., Holtfreter, B., Gravemeier, M., Harmsen, D., & Ehmke, B. (2015). Is progression of periodontitis relevantly influenced by systemic antibiotics? A clinical randomized trial. Journal of Clinical Periodontology, 42(9), 832–842. https://doi.org/10.1111/jcpe.12441.

Borges, I., Faveri, M., Figueiredo, L. C., Duarte, P. M., Retamal-Valdes, B., Montenegro, S. C. L., & Feres, M. (2017). Different antibiotic protocols in the treatment of severe chronic periodontitis: A 1-year randomized trial. Journal of Clinical Periodontology, 44(8), 822–832. https://doi.org/10.1111/jcpe.12721.

Serhan, C. N. (2014). Pro-resolving lipid mediators are leads for resolution physiology. Nature, 510(7503), 92–101. https://doi.org/10.1038/nature13479.

El-Sharkawy, H., Aboelsaad, N., Eliwa, M., Darweesh, M., Alshahat, M., Kantarci, A., Hasturk, H., & Van Dyke, T. E. (2010). Adjunctive Treatment of Chronic Periodontitis with Daily Dietary Supplementation with Omega-3 Fatty Acids and Low-Dose Aspirin. Journal of Periodontology, 81(11), 1635–1643. https://doi.org/10.1902/jop.2010.090628.

Keskiner, I., Saygun, I., Bal, V., Serdar, M., & Kantarci, A. (2017). Dietary supplementation with low-dose omega-3 fatty acids reduces salivary tumor necrosis factor-α levels in patients with chronic periodontitis: a randomized controlled clinical study. Journal of Periodontal Research, 52(4), 695–703. doi:10.1111/jre.12434.

Cholewski, M., Tomczykowa, M., & Tomczyk, M. (2018). A Comprehensive Review of Chemistry, Sources and Bioavailability of Omega-3 Fatty Acids. Nutrients, 10(11), 1662. doi:10.3390/nu10111662.

Shahidi, F., & Ambigaipalan, P. (2018). Omega-3 Polyunsaturated Fatty Acids and Their Health Benefits. Annual Review of Food Science and Technology, 9(1), 345–381. doi:10.1146/annurev-food-111317-095850.

Naqvi, A. Z., Hasturk, H., Mu, L., Phillips, R. S., Davis, R. B., Halem, S., … Mukamal, K. J. (2014). Docosahexaenoic Acid and Periodontitis in Adults. Journal of Dental Research, 93(8), 767–773. doi:10.1177/0022034514541125.

Belhomme, N., Doudnikoff, C., Polard, E., Henriot, B., Isly, H., & Jego, P. (2017). Aspirine indications et utilisation durant la grossesse. La Revue de Médecine Interne, 38(12), 825–832. doi:10.1016/j.revmed.2017.10.419.

Block, R. C., Shearer, G. C., Holub, A., Tu, X. M., Mousa, S., Brenna, J. T., … Tintle, N. (2021). Aspirin and omega-3 fatty acid status interact in the prevention of cardiovascular diseases in Framingham Heart Study. Prostaglandins, Leukotrienes and Essential Fatty Acids, 169, 102283. doi:10.1016/j.plefa.2021.102283.

Thirkettle, S., Decock, J., Arnold, H., Pennington, C. J., Jaworski, D. M., & Edwards, D. R. (2013). Matrix Metalloproteinase 8 (Collagenase 2) Induces the Expression of Interleukins 6 and 8 in Breast Cancer Cells. Journal of Biological Chemistry, 288(23), 16282–16294. doi:10.1074/jbc.m113.464230.

De Souza, A.P.; Line, S.R.P. The biology of matrix metalloproteinases. Rev. FOB, v. 10, n. 1, p. 1-6, jan./mar. 2002.

Figueredo, C.M.S et al. The short-term effectiveness of non-surgical treatment in reducing protease activity in gingival crevicular fluid from chronic periodontitis patients. J Clin Periodontal, v.31, p.615-619, 2004. http://www.redalyc.org/articulo.oa?id=63711504014.

Lima, Manoel Pereira de et al. Diagnóstico de doenças periodontais por meio de biomarcadores salivares: revisão de literatura. SALUSVITA, Bauru, v. 38, n. 3, p. 811-820, 2019.

Xiong, J.; Piemontese, M.; Onal, M.; Campbell, J.; Goellner, J. J.; Dusevich, V.; Bonewald, L.; Manolagas, S. C.; O'Brien, C. A. Osteocytes, not osteoblasts or lining cells, are the mains source of the RANKL required for osteoclast formation in remodeling bone. PLoS ONE, v. 10, n. 9, 2015. https://doi.org/10.1371/journal.pone.0138189.

Belibasakis GN, Bostanci N. The RANKL-OPG system in clinical periodontology. J Clin Periodontol. 2012;39:239-48. https://doi.org/10.1111/j.1600-051X.2011.01810.x.

Jabbar S, Drury J, Fordham J, Datta HK, Francis RM, Tuck SP. Plasma vitamin D and cytokines in periodontal disease and postmenopausal osteoporosis. J Periodontal Res. 2011;46:97-104. https://doi.org/10.1111/j.1600-0765.2010.01317.x.

Oliveira, C. M. B. de, Sakata, R. K., Issy, A. M., Gerola, L. R., & Salomão, R. (2011). Citocinas e dor. Revista Brasileira de Anestesiologia, 61(2), 260–265. https://doi.org/10.1590/s0034-70942011000200014.

Akalin, F. A., Toklu, E., & Renda, N. (2005). Analysis of superoxide dismutase activity levels in gingiva and gingival crevicular fluid in patients with chronic periodontitis and periodontally healthy controls. Journal of Clinical Periodontology, 32(3), 238–243. https://doi.org/10.1111/j.1600-051x.2005.00669.x.

Rogero, M. M., Leão, M. de C., Santana, T. M., Pimentel, M. V. d. M. B., Carlini, G. C. G., da Silveira, T. F. F., … Castro, I. A. (2020). Potential benefits and risks of omega-3 fatty acids supplementation to patients with COVID-19. Free Radical Biology and Medicine, 156(June), 190–199. https://doi.org/10.1016/j.freeradbiomed.2020.07.005.

Balta, M. G., Papathanasiou, E., Blix, I. J., & Van Dyke, T. E. (2021). Host Modulation and Treatment of Periodontal Disease. Journal of Dental Research. https://doi.org/10.1177/0022034521995157.

Marouf, N., Cai, W., Said, K. N., Daas, H., Diab, H., Chinta, V. R., … Tamimi, F. (2021). Association between periodontitis and severity of COVID-19 infection: A case–control study. Journal of Clinical Periodontology, 0–2. https://doi.org/10.1111/jcpe.13435.

Queiroz Tavares R, Nogueira de Figueiredo M, Bustillos Torrez W, Fernandes Plutarco Nogueira C, Ferrari Roberto A, Rossit Silva Kiausinis KM, Feres M, Retamal-Valdes B. USO DE PROBIÓTICOS SISTÊMICOS NO TRATAMENTO PERIODONTAL NÃO CIRÚRGICO: REVISÃO NARRATIVA DA LITERATURA. RECIMA21 [Internet]. 12º de novembro de 2020 [citado 21º de setembro de 2021];1(2):280-30. Disponível em: https://recima21.com.br/index.php/recima21/article/view/42.

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01/05/2022

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Nascimento de Brito Silva, R., Castro dos Santos, N., & Feres, M. (2022). ÔMEGA-3 E ASPIRINA COMO ADJUVANTES NO TRATAMENTO PERIODONTAL: REVISÃO DE LITERATURA. RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, 3(5), e351295. https://doi.org/10.47820/recima21.v3i5.1295

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