ATIVIDADES FARMACOLÓGICAS DE BERGININA E DERIVADOS: UMA REVISÃO SISTEMÁTICA

Diana Mendes do Nascimento Veloso; Patrícia Danielle Oliveira de Almeida; Emersom Silva Lima

doi:10.47820/recima21.v4i1.2615

Autores

Diana Mendes do Nascimento Veloso Universidade Federal do Amazonas https://orcid.org/0000-0001-6395-1434
Patricia Danielle Oliveira de Almeida Universidade Federal do Amazonas https://orcid.org/0000-0002-2620-8251
Emersom Silva Lima Universidade Federal do Amazonas https://orcid.org/0000-0002-9367-2812

DOI:

https://doi.org/10.47820/recima21.v4i1.2615

Palavras-chave:

Bergenina, atividade farmacológica, síntese, anti-inflamatório, antioxidante

Resumo

A bergenina é um C-glicosídeo do ácido 4-O-metil-gálico, caracteriza-se como um polifenol cristalino e incolor. Há relatos de ter sido isolada de plantas medicinais como Flueggea leucopyrus, Bergenia crassifolia, Mallotus philippensis, Corylopsis spicata, Caesalpinia digyna, Mallotus japonicus e Sacoglottis gabonensis. Na região amazônica especificamente a bergenina é listada como um dos principais compostos bioativos presentes na espécie Endopleura uchi, popularmente conhecida como uchi amarelo. É uma substância que possui múltiplas propriedades farmacológicas como anti-inflamatória, antitumoral, citoprotetora, antiarrítmica, antimicrobiana, antidiabética dentre outras. Por meio de um levantamento bibliográfico nas bases de dados PubMed e Science Direct, entre 2016 e 2022, utilizando os descritores “bergenin”, “pharmacological activity”, “synthesis” e “antioxidant”, após a aplicação dos critérios de inclusão e exclusão, foram avaliados um total de 35 artigos sobre a bergenina e derivados. Os resultados evidenciaram que as propriedades farmacológicas mais recorrentes atribuídas à bergenina, foram aquelas relacionadas as atividades anti-inflamatórias (8 publicações), seguida de antitumoral (5 publicações), citoproteção (5 publicações), ação sobre o metabolismo ósseo (3 publicações), imunomoduladora (3 publicações), antiparasitária (2 publicações) e atividade antioxidante (2 publicações). Dos 35 artigos estudados, seis eram produções relacionadas a derivados da bergenina, os quais estudaram propriedades anti-inflamatória e antitumoral. Esta revisão apresenta uma pesquisa bibliográfica abrangente de diferentes estudos e fornece informações sobre a potencialidade da bergenina e seus derivados para uso e desenvolvimento de novos fármacos.

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Biografia do Autor

Diana Mendes do Nascimento Veloso, Universidade Federal do Amazonas

Laboratório de Atividade Biológica, Faculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas

Patricia Danielle Oliveira de Almeida, Universidade Federal do Amazonas

Laboratório de Atividade Biológica, Faculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas.

Emersom Silva Lima, Universidade Federal do Amazonas

Laboratório de Atividade Biológica, Faculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas.

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