PHARMACOLOGICAL ACTIVITIES OF BERGENIN AND DERIVATIVES: A SYSTEMATIC REVIEW
DOI:
https://doi.org/10.47820/recima21.v4i1.2615Keywords:
Bergenine, pharmacological activity, synthesis, anti-inflammatory, antioxidantAbstract
Bergenine is a C-glycoside of 4-O-methyl-gallic acid, characterized as a crystalline and colorless polyphenol. It has been reported to have been isolated from medicinal plants such as Flueggea leucopyrus, Bergenia crassifolia, Mallotus philippensis, Corylopsis spicata, Caesalpinia digyna, Mallotus japonicus and Sacoglottis gabonensis. In the Amazon region specifically, bergenine is listed as one of the main bioactive compounds present in the species Endopleura uchi, popularly known as yellow uchi. It is a substance that has multiple pharmacological properties such as anti-inflammatory, antitumor, cytoprotective, antiarrhythmic, antimicrobial, antidiabetic, among others. Through a bibliographic survey in the PubMed and Science Direct databases, between 2016 and 2022, using the descriptors “bergenin”, “pharmacological activity”, “synthesis” and “antioxidant”, after applying the inclusion and exclusion criteria, a total of 35 articles on bergenine and derivatives were evaluated. The results showed that the most recurrent pharmacological properties attributed to bergenine were those related to anti-inflammatory activities (8 publications), followed by antitumor (5 publications), cytoprotection (5 publications), action on bone metabolism (3 publications), immunomodulatory (3 publications), antiparasitic (2 publications) and antioxidant activity (2 publications). Of the 35 articles studied, six were productions related to bergenine derivatives, which studied anti-inflammatory and antitumor properties. This review presents a comprehensive literature search of different studies and provides information on the potential of bergenine and its derivatives for the use and development of new drugs.
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