BIOTECHNOLOGY AND GENETIC ENGINEERING: CURRENT ADVANCEMENTS, EMERGING CHALLENGES, AND FUTURE HORIZONS IN MODERN SCIENCE
DOI:
https://doi.org/10.47820/recima21.v5i2.4797Palavras-chave:
Biotechnology, Diseases, Gene TherapyResumo
Biotechnology is the term given to the branch of science that employs knowledge, techniques, and genetic engineering methods for creating various products using living organisms as raw material. Although this term has been recently adopted, humans have long been manipulating biological processes for their own benefit. Biotechnology is multidisciplinary and encompasses various fields of knowledge, with significant progress achieved over the years, particularly in the medical and cosmetic sectors. Through genetic engineering, it has become possible to edit genes more precisely, revolutionizing the study and manipulation of DNA and allowing the proposal and use of strategies that were once unthinkable in the scientific field to address contemporary issues. Among its most recent contributions are the development of new drugs and biopharmaceuticals, vaccines, cellular, genetic, and protein therapies, as well as the production of biocosmetics. However, there are still challenges to be faced in the extensive use of genetic engineering, ranging from production costs and the success of the technique at the molecular level to ethical issues surrounding the application of this technology. Thus, this literature review aims to discuss the most recent advances, applications, and future perspectives of biotechnology and genetic engineering in the scientific field.
Downloads
Referências
BELI, C. M.; MAGESTE, J. M.; TAKETANI, N. F. BIOPROSPECÇÃO DE ENZIMAS PARA COSMÉTICA: SEU IMPACTO NA BIOTECNOLOGIA. Revista Ensaios Pioneiros, v. 3, n. 2, p. 10–24, 25 mar. 2020. DOI: https://doi.org/10.24933/rep.v3i2.199
BHARDWAJ, A. et al. TALENs-an indispensable tool in the era of CRISPR: a mini review. Journal, genetic engineering & biotechnology, v. 19, n. 1, p. 125, ago 2021. DOI: https://doi.org/10.1186/s43141-021-00225-z
BOCH, J. et al. Breaking the code of DNA binding specificity of TAL-type III effectors. Science, v. 326, p. 1509–1512, dez. 2009. DOI: https://doi.org/10.1126/science.1178811
CARDOZO, Karina H. M. et al. Metabolites from algae with economical impact. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, v. 146, n. 1-2, p. 60-78, 2007. DOI: https://doi.org/10.1016/j.cbpc.2006.05.007
CHEN, M. et al. CRISPR-Cas9 for cancer therapy: Opportunities and challenges. Cancer letters, v. 447, p. 48–55, abr. 2019. DOI: https://doi.org/10.1016/j.canlet.2019.01.017
CLARK, D. P.; PAZDERNIK, N. J. Biotechnology. Amsterdam; Boston: Elsevier/Academic Cell Press, 2016.
DASH, P. K. et al. Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice. Nature Communications, v. 10, n. 1, 2 jul. 2019.
DELHOVE, J. et al. Public acceptability of gene therapy and gene editing for human use: a systematic review. Human gene therapy, v. 31, n. 1-2, p. 20-46, jan. 2020. DOI: https://doi.org/10.1089/hum.2019.197
DOS SANTOS, V. S.; WIETHÖLTER, P. Contribuições da engenharia genética no tratamento de doenças / Contributions of genetic engineering in the treatment of diseases. Brazilian Journal of Development, [S. l.], v. 7, n. 3, p. 31157–31176, 2021. DOI: 10.34117/bjdv7n3-711. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/27129. Acesso em: 27 dec. 2023. DOI: https://doi.org/10.34117/bjdv7n3-711
EMBRAPA. Aquicultura. Brasilia: Embrapa, 2020. Disponivel em: https://www.embrapa.br. Acessado em: 22 dez. 2020.
HONG, W. et al., A new and promising application of gene editing: CRISPRcontrolled smart materials for tissue engineering, bioelectronics, and diagnostics, China Life Science, n. 62, v. 11, p. 1547–1549, nov. 2019. DOI: https://doi.org/10.1007/s11427-019-1576-0
HUANG, C.-H.; LEE, K.-C.; DOUDNA, J. A. Applications of CRISPR-Cas Enzymes in Cancer Therapeutics and Detection. Trends in Cancer, v. 4, n. 7, p. 499–512, jul. 2018. DOI: https://doi.org/10.1016/j.trecan.2018.05.006
LINO, C. A.; HARPER, J. C.; CARNEY, J. P.; TIMLIN, J. A. Delivering CRISPR: a review of the challenges and approaches. Drug delivery, v. 25, n. 1, p. 1234–1257, 2018. DOI: https://doi.org/10.1080/10717544.2018.1474964
NAEEM, M. et al. Developed Strategies to Minimize the Off-Target Effects in CRISPR-Cas-Mediated Genome Editing. Cells, n. 7, p. 1608, jul. 2020. DOI: https://doi.org/10.3390/cells9071608
PAUL, B. et al. CRISPR-Cas12a: Functional overview and applications. Biomedical journal, v. 4, n. 1, p. 8–17, fev. 2020. DOI: https://doi.org/10.1016/j.bj.2019.10.005
ROSALES-MENDOZA, Sergio et al. The potential of algal biotechnology to produce antiviral compounds and biopharmaceuticals. Molecules, v. 25, n. 18, p. 4049, 2020. DOI: https://doi.org/10.3390/molecules25184049
SALZMAN, R. et al. Addressing the Value of Gene Therapy and Enhancing Patient Access to Transformative Treatments. Molecular Therapy, v. 26, p. 2717-2726, dez. 2018. DOI: https://doi.org/10.1016/j.ymthe.2018.10.017
SAYED, N. et al. Gene therapy: Comprehensive overview and therapeutic applications. Life sciences, v. 294, n. 120375, dez. 2020. DOI: https://doi.org/10.1016/j.lfs.2022.120375
WANI, A. K. et al. Genome centric engineering using ZFNs, TALENs and CRISPR-Cas9 systems for trait improvement and disease control in Animals. Veterinary research communications, v. 47, n. 1, p. 1–16, jan. 2023. DOI: https://doi.org/10.1007/s11259-022-09967-8
YAN, Na et al. The potential for microalgae as bioreactors to produce pharmaceuticals. International journal of molecular sciences, v. 17, n. 6, p. 962, 2016. DOI: https://doi.org/10.3390/ijms17060962
YASSA, N. W. et al. Ipriflavone and Ipriflavone loaded albumin nanoparticles reverse lipopolysaccharide induced neuroinflammation in rats. PLOS ONE, v. 15, n. 8, p. e0237929, 21 ago. 2020. DOI: https://doi.org/10.1371/journal.pone.0237929
ZHANG, C. et al. Advances in mRNA vaccines for infectious diseases. Frontiers in Immunology, v. 10, n. 594, 27 mar. 2019. DOI: https://doi.org/10.3389/fimmu.2019.00594
Downloads
Publicado
Licença
Copyright (c) 2024 RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Os direitos autorais dos artigos/resenhas/TCCs publicados pertecem à revista RECIMA21, e seguem o padrão Creative Commons (CC BY 4.0), permitindo a cópia ou reprodução, desde que cite a fonte e respeite os direitos dos autores e contenham menção aos mesmos nos créditos. Toda e qualquer obra publicada na revista, seu conteúdo é de responsabilidade dos autores, cabendo a RECIMA21 apenas ser o veículo de divulgação, seguindo os padrões nacionais e internacionais de publicação.